Analgesic effect of Ga‐Al‐As diode laser irradiation on hyperalgesia in carrageenin‐induced inflammation

Honmura, Akie; Ishii, Akemi; Yanase, Masahiro; Obata, Junichi; Haruki, Eiichi

doi:10.1002/lsm.1900130411

Cited by 98 publications

(47 citation statements)

References 23 publications

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“…Currently, there are methods to alleviate the inflammatory process, providing the improvement of cellular nutrition and favoring the injured tissue repair, particularly the low level laser therapy (LLLT) 2,4 . The LLLT has been clinically used for pain control and wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…The LLLT has been clinically used for pain control and wound healing. The effectiveness of this therapy is due to responses induced by the cellular level photobiomodulation promoting acceleration of cellular metabolism, reducing inflammation, increasing local microcirculation and the lymphatic system, leading to the decrease of the interstitial edema and increase of the collagen synthesis [4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of low level laser on sutured wound healing in rats

et al. 2011

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Purpose:To evaluate the effect of low-level laser therapy (LLLT) ë904 nm on healing of surgical wounds in rats. Methods: Forty male Wistar rats were used, divided into four groups, underwent incision along the lines Alba covering skin, subcutaneous and muscle abdominal, sutured continuously for nylon 5-0. Eight and fifteen days after the surgery process, the repairing area was removed and histological sections were stained with hematoxylin-eosin to assess cellularity inflammatory, Masson´s Trichrome and Picrossirus to quantify the collagen fibers and immunohistochemical technique for counting newly formed vessels. The data were compared statistically using analysis of variance ANOVA, with a "post-hoc Tukey test, p <0.05. Results: Low-level laser therapy reduced the intensity of the inflammatory reaction and influenced the dynamic of the immunoinflammatory response by inducing switching of the leukocyte infiltration pattern (neutrophilic to lymphoplasmacytic infiltration). Also stimulate the deposition and enhance the organization of collagen fibers, featuring a delicate collagen type III. Furthermore, it appeared to a significant increase in the average number of newly formed vessels (p = 0.00 and p = 0.02, respectively). Conclusion: Low-level laser therapy resulted in modulate of the inflammatory response, enhanced deposition of collagen fibers and increase in the average number of newly formed vessels. Key words: Wound Healing. Lasers, Semiconductor. Collagen. Macrophages. Rats. RESUMO Objetivo:Avaliar o efeito da terapia laser de baixa potência (TLBP) ë904 nm na cicatrização de feridas cirúrgicas em ratos. Métodos: Foram utilizados 40 ratos Wistar, machos, divididos em quatro grupos, submetidos à incisão na linha Alba abrangendo pele, subcutâneo e musculatura abdominal, suturados continuamente por fios de nylon 5-0. Oito e quinze dias após o procedimento cirúrgico, a área de reparo foi removida e os cortes histológicos foram corados com hematoxilina-eosina para avaliar celularidade do infiltrado inflamatório, Tricrômico de Masson e Picrosirius para quantificar as fibras de colágeno e técnica imuno-histoquímica para a contagem de vasos neoformados. Os dados foram comparados estatisticamente pela análise de variância ANOVA, com "teste de Tukey post-hoc, p <0,05. Resultados: A terapia laser de baixa potência reduziu a intensidade da reação inflamatória e influenciou a dinâmica da resposta imuno por induzir a mudança do padrão de infiltração de leucócitos (neutrófilos a infiltração mononuclear). Como também estimula a deposição e melhora padrão organizacional das fibras colágenas, apresentando um delicado colágeno tipo III. Além disso, verificou-se um aumento significativo no número médio de vasos neoformados (p = 0,00 e p = 0,02, respectivamente). Conclusão: A terapia laser de baixa potência modula a resposta inflamatória, com melhor deposição de fibras colágenas e aumento do número médio de vasos neoformados. Descritores: Cicatrização de Feridas. Lasers Semicondutores. Colágeno. Macrófagos. Ratos. -Act...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of low level laser on sutured wound healing in rats

et al. 2011

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“…8 Biological e®ects of light include wound healing, pain reduction, and alleviation of oral mucositis. [9][10][11][12] E®ects such as cytoprotection, cellular proliferation, growth factor release have also been reported. [13][14][15] Studies have indicated the e®ects of NIR on nervous system, like AD.…”

Section: Introductionmentioning

confidence: 99%

Near infra-red light treatment of Alzheimer’s disease

Han

Wang

Xue

et al. 2017

J. Innov. Opt. Health Sci.

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Alzheimer's disease (AD) is a chronic neurodegenerative disease. The symptoms include memory and spatial learning di±culties, language disorders, and loss of motivation, which get worse over time, eventually ending in death. No e®ective treatments are available for AD, currently. Current treatments only attenuate symptoms temporarily and are associated with severe side e®ects. Near infra-red (NIR) light has been studied for a long time. We investigated the e®ect of NIR on AD using a transgenic mouse model, which was obtained by co-injecting two vectors carrying AD mutations in amyloid precursor protein (APP) and presenilin-1 (PSEN1) into C57BL/6J mice. The irradiation equipment consisted of an accommodating box and an LED array. The wavelength of NIR light emitted from LED was between 1040 nm and 1090 nm. The power density delivered at the level of the mice was approximately 15 mW/cm 2 . Firstly, we treated the mice with NIR for 40 days. Then, the irradiation was suspended for 28 days. Finally, another 15 days treatment was brought to mice. We conducted Morris water maze and immuno°uorescence analysis to evaluate the e®ects of treatment. Immuno°uorescence analysis was based on measuring the quantity of plaques in mouse brain slices. Our results show that NIR light improves memory and spatial learning ability and reduces plaques moderately. NIR light represents a potential treatment for AD.

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“…With regard to attenuation of pain caused by some mechanism unpleasant to the body or by tissue injury, it may be mediated by endogenous opioid system interactions. This is responsible for modulating pain by the action of encephalins and β-endorphins in charge of inducing analgesic effects and influencing nociceptive stimulus perception due to their action on opioid receptors 7 . A possibility for the analgesic effect of low power laser is peripheral opioids release from immune system cells, with significant release of local β-endorphins 8,9 , in addition to the independent effect on opioid receptors 10 .…”

Section: Introductionmentioning

confidence: 99%