Analgesic effect of Dioclea grandiflora constituents in rodents

Antinociceptive and Toxicological Effects ofDioclea grandifloraSeed Pod in Mice

“…However, the effect was not dose dependent as the doses used (75, 150, and 300 mg/kg) produced similar responses in the treated animals (i.e., inhibitory effect). This finding supports the results obtained by previous works that demonstrated the analgesic effect of seeds and root bark of D. grandiflora in rodents [2, 9]. …”

“…For instance, D. grandiflora , a plant traditionally used for treating kidney and prostate diseases [1], is known to have significant activity on the central nervous system [2]. The phytochemical analysis of seeds and root bark of this plant led to the isolation and identification of various substances, namely dioclein, dioclenol, and dioflorin, which have been reported to have antinociceptive activity in rodents [4–6].…”

“…In folk medicine, the seed and root bark of this plant have been widely used to treat prostate disorders and kidney stones [1]. Previous studies reported a significant central nervous system (CNS) activity of the chloroformic (CHCl 3 ) and ethanolic extract obtained from the dried root bark [2] and the hydroalcoholic extract from the seeds of D. grandiflora [3]. …”

“…Subsequently, paraibanol, agrandol, and diosalol were also isolated from the root bark of this plant [7]. Its major constituent, dioclein, was reported to have significant analgesic effect in rodents [2] and a potent vasorelaxant endothelium-dependent effect in the rat aorta [8]. Later, a pharmacological screening revealed the antinociceptive activity of dioclenol and dioflorin in mice [9].…”

Toxicidade Aguda em Ratos Wistar Tratados com o Extrato Etanólico de Dioclea grandiflora Mart. Ex Benth (Fabaceae) (EEDg)

“…Estudos fitoquímicos mostrou a presença de várias substâncias na Dioclea grandiflora, tais como o paraibanol, agrandol e diosalol (8), dioclein, dioflorin, diidroflavonol, dioclenol [9][10] , isolado a partir do clorofórmio (CHCI3) porção solúvel do extrato de casca da raiz desta planta. Investigações anteriores evidenciaram uma atividade significativa no SNC do extrato etanólico obtido a partir da casca da raiz seca 11 , e do extrato hidroalcoólico a partir das sementes de Dioclea grandiflora 12 . O seu principal constituinte, diocleína, tem um efeito analgésico significativo em roedores 13 , e um efeito vasorrelaxante no endotélio da aorta de rato 14 .…”