Analgesic effect and related amino acids regulation of ginsenoside Rg3 in mouse pain models

Sun, Yuqi; Shi, Shudan; Zheng, Yan‐Zhen; Liu, Yaru; Wang, Shuo; Fu, Li; Dai, Chunmei

doi:10.1016/j.lfs.2019.117083

Cited by 5 publications

(1 citation statement)

References 35 publications

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“… 2018 ; Sun et al. 2019 ). Therefore, we speculated that compound DB might be the main analgesic constituent of D. trilobus for the treatment of pain.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive activity of doliroside B

Bai

et al. 2023

Pharmaceutical Biology

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Context Dolichos trilobus Linn (Leguminosae) is often used in Yi ethnic medicine to treat pain, fracture, and rheumatism. Objective To explore the therapeutic potential of doliroside B (DB) from D. trilobus and its disodium salt (DBDS) and the underlying mechanism in pain. Materials and methods In the writhing test, Kunming mice were orally treated with DB and DBDS at doses of 0.31, 0.62, 1.25, 2.5, and 5 mg/kg. Vehicle, morphine, indomethacin, and acetylsalicylic acid were used as negative and positive control on the nociception-induced models, respectively. In the hot plate test, mice were orally treated with DB and DBDS at doses of 2.5, 5, 10, and 20 mg/kg. In the formalin test, mice were orally treated with DB and DBDS at doses of 2.5, 5, 10, and 20 mg/kg. In the meanwhile, lipopolysaccharide-induced inflammatory model in RAW264.7 macrophages was adopted to study the mechanism of pain alleviation for DBDS. Results DBDS (5 mg/kg) inhibited the writhing number by 80.2%, which exhibited the highest antinociceptive activity in pain models. DBDS could selectively inhibite the activity of COX-1. Meanwhile, it also reduced the production of NO, iNOS, and IL-6 by 55.8%, 69.0%, and 49.9% inhibition, respectively. It was found that DBDS also positively modulated the function of GABA A1 receptor. Discussion and conclusions DBDS displayed antinociceptive activity by acting on both the peripheral and central nervous systems, which may act on multitargets. Further work is warranted for developing DBDS into a potential drug for the treatment of pain.

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“… 2018 ; Sun et al. 2019 ). Therefore, we speculated that compound DB might be the main analgesic constituent of D. trilobus for the treatment of pain.…”

Section: Introductionmentioning

confidence: 99%