Analgesic effect and mechanism of the three TCM-herbal drug-combination Tou Feng Yu Pill on treatment of migraine

Jia-chuan, LI; Shen, Xiaofei; Meng, Xianli; Zhang, Yi; Lai, Xianrong

doi:10.1016/j.phymed.2011.01.008

Cited by 45 publications

(31 citation statements)

References 11 publications

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“…Following NTG injection, the number of head-scratching in the NTG group, EA group, and NA group increased significantly from NTG injection to 60 min compared to the control group ( P < 0.01) (Figure 6(a)). Specially, the number of head-scratching in the NTG group significantly increased from NTG injection to 60 min and from 120 min to 240 min, indicating that a successful rat model of acute migraine had been established [21]. Secondly, 20 min of EA at acupoints and EA at nonacupoints treatments were performed accordingly on EA and NA groups from 60 min to 120 min after NTG injection.…”

Section: Resultsmentioning

confidence: 99%

“…In the series of discomfort symptoms exhibited by NTG rats after being administered with nitroglycerin, “head-scratching,” which resembles the attack of human migraine, was quantitatively measured as an important observation index in acute migraine rat model [21]. The number of head-scratching obviously increased ( P < 0.01) after NTG injection and lasted for 4 h, manifesting the key signal of success of acute migraine model.…”

Section: Discussionmentioning

confidence: 99%

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Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A ¹H NMR‐Based Metabolomic Study

Gao

Liu

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Background. The objective of this study was to identify potential biomarkers of electroacupuncture (EA) on relieving acute migraine through metabolomic study. Methods. EA treatments were performed on both acupoints and nonacupoints on the nitroglycerin (NTG)-induced migraine rat model. NMR experiments and multivariate analysis were used for metabolomic analysis. Results. The number of head-scratching, the main ethology index of migraine rat model, was significantly increased (P < 0.01) after NTG injection. The plasma metabolic profile of model group was distinct from that of the control group. Glutamate was significantly increased (P < 0.01), whereas lipids were significantly decreased (P < 0.01) in model rats. After EA at acupoints, the metabolic profile of model rats was normalized, with decreased glutamate (P < 0.05) and increased lipids (P < 0.01). In contrast, EA at nonacupoints did not restore the metabolic profile, but with six metabolites significantly different from acupoints group. Interestingly, the number of head-scratching and glutamate level were significantly decreased (P < 0.05) after receiving EA at both acupoints and nonacupoints. Conclusions. EA at acupoints may relieve acute migraine by restoring the plasma metabolic profile and plasma glutamate, while EA at nonacupoints may modestly relieve acute migraine by decreasing plasma glutamate.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A ¹H NMR‐Based Metabolomic Study

Gao

Liu

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…A number of patients who experience pain symptoms are successfully treated with herbal medicines. Tou-Feng-Yu Pill, a common Chinese medicine formula, displays anti-nociceptive effects on migraines by modulating the levels of neurotransmitters and bioactive substances (Li et al, 2011). Our group successfully verified that Jia-Yuan-Qing Pill exerts significant antinociception effects via the regulation of peripheral nerves, without toxicity or physical dependence (Tian et al, 2014).…”

Section: Introductionmentioning

confidence: 67%

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

Wang

Jia

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Paecilomyces hepiali (PH), a well-known medicinal fungus, has various pharmacological efficacies. In our study, the antinociceptive effects of PH and underlying mechanisms were evaluated using various mouse models. An acetic acid-induced writhing test, hot plate test, and formalin test were employed to evaluate the antinociceptive activities of PH. The levels of neuronal nitric oxide synthase (nNOS) in the hypothalamus and monoamine neurotransmitters in the serum and hypothalamus of experimental mice were examined. Additionally, hot plate tests using mice pretreated with various antagonists were used to determine the mechanisms of PHmediated antinociception. The PH-enhanced latency period of mice in the hot plate test was significantly blocked by pretreatment with atropine and glibenclamide. PH shortened the phase I and phase II reaction times of formalin-treated mice. Strongly reduced writhing and stretching induced by acetic acid were observed in PH-treated mice, indicating that PH mainly exerts antinociceptive activity on neurogenic pain. After thermal pain stimulation for 30 s, compared to control mice, 7-day PH-treated mice had lower nNOS and dopamine levels, and increased levels of serotonin in both the serum and hypothalamus. Collectively, our data showed that PH mediated antinociceptive activities via multiple pathways, including monoamines, nNOS/ATPsensitive K + channels, and M-type acetylcholine receptors.

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“…The study of TFY on treating migraines was mostly used in clinic settings. However, the pharmacodynamic material bases and effect mechanism of TFY were not yet understood clearly and there was a lack of rigorous scientific evaluation about it [14,15]. (3) Cang-ersan is composed of Cangerzi (fruits of Xanthium sibiricum), Xinyi (flower buds of Magnolia biondii), Baizhi (roots of A. dahurica) and Bohe (aerial part of Mentha haplocalycx).…”

Section: Applicationsmentioning

confidence: 99%

Angelica dahurica (Fish. ex Hoffm.) Benth. et Hook. f. 白芷 (Baizhi, Chinese Angelica)

2015

Dietary Chinese Herbs

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Analgesic effect and mechanism of the three TCM-herbal drug-combination Tou Feng Yu Pill on treatment of migraine

Cited by 45 publications

References 11 publications

Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A ¹H NMR‐Based Metabolomic Study

Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A ¹H NMR‐Based Metabolomic Study

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

Angelica dahurica (Fish. ex Hoffm.) Benth. et Hook. f. 白芷 (Baizhi, Chinese Angelica)

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Analgesic effect and mechanism of the three TCM-herbal drug-combination Tou Feng Yu Pill on treatment of migraine

Cited by 45 publications

References 11 publications

Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A 1H NMR‐Based Metabolomic Study

Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A 1H NMR‐Based Metabolomic Study

Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models

Angelica dahurica (Fish. ex Hoffm.) Benth. et Hook. f. 白芷 (Baizhi, Chinese Angelica)

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Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A ¹H NMR‐Based Metabolomic Study

Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A ¹H NMR‐Based Metabolomic Study