Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC.

Bahadır, Özlem; Çitoğlu, Gülçin Saltan; Šmejkal, Karel; Dall’Acqua, Stefano; Özbek, Hanefí; Cvačka, Josef; Žemlička, Milan

doi:10.1016/j.jep.2010.06.003

Cited by 28 publications

(28 citation statements)

References 22 publications

(19 reference statements)

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“…Mouse ear edema induced with topically-applied TPA is also an excellent acute inflammation animal model, closely Scorzonera species were in focus of our previous research touching testing of analgesic, anti-inflammatory, and wound healing activities. Aerial part extracts of Scorzonera showed significant inhibitory effects in carrageenan and PGE 2 induced hind paw edema model in vivo [21][22][23]. The concentrations of extracts showing the activity was 100 mg/kg of body weight of mice, and the effect was comparable with indomethacine used as the standard at the some concentration.…”

Section: Resultsmentioning

confidence: 86%

“…From the above mentioned, we suggested that chlorogenic acid (8), derivatives of dicaffeoyl-quinic acid (6 and 7), and flavonoids, especially quercetin-3-O-β-D-glucoside (1) and hyperoside (2) could be responsible for the anti-inflammatory activity of tested extracts. Therefore, further experiments were carried out with phenolic compounds previously obtained from Scorzonera species (1)(2)(3)(4)(5)(6)(7)(8), to assay the inhibition of TNF-α and IL-1β production in THP-1 cells, and later also with triterpenes 9-16, because taraxasterol acetate (9) isolated from S. latifolia showed previously analgesic activity in vivo in writhing and tail-flick tests [21] and also other triterpenoid substances like lupeol derivatives (10 and 11), β-sitosterol (12) and other triterpenes (13)(14)(15)(16) could potentially demonstrate anti-phlogistic effect [38,39]. Unfortunately, only weak activity of compounds tested was observed, and no statistically significant activity has been observed in comparison with standard used (prednisone, Supplementary Materials, Figure S1).…”

Section: Resultsmentioning

confidence: 99%

“…In order to verify traditional usage of Scorzonera species, anti-nocieptive, anti-inflammatory, and wound healing activities have been evaluated and promising results have been obtained in our previous research [21][22][23][24]. The aim of the current study was to evaluate the ability of Scorzonera extracts to inhibit TNF-α and IL-1β production and NF-κB nuclear translocation in LPS-stimulated THP-1 macrophages, which may be responsible for the observed anti-inflammatory activity.…”

Section: Introductionmentioning

confidence: 94%

“…Phenolic constituents of Scorzonera species found in Scorzonera extracts and tested for TNF-α production inhibition. Figure 5) and terpenoids 9-16 [taraxasterol acetate (9), lupeol (10), lupeol acetate (11), β-sitosterol (12), 3-β-hydroxy-fern-8-en-7-one-acetate (13), urs-12-en-11-one-3-acetyl (14), 3-β-hydroxy-fern-7-en-6-one-acetate (15), olean-12-en-11-one-3-acetyl (16)] (Figure 6) used for assays were isolated from Scorzonera species according to the procedures showed in [47][48][49]. Figure 6.…”

Section: Hplc Analysismentioning

confidence: 99%

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Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-κB Activation, Showing Anti-Inflammatory Effect in Vitro

et al. 2015

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Scorzonera species are used in different folk medicines to combat many diseases, including the illnesses connected with inflammation. Previous experiments showed anti-inflammatory activity of Scorzonera extracts in vivo. S. latifolia, S. cana var. jacquiniana, S. tomentosa, S. mollis ssp. szowitsii, S. eriophora, S. incisa, S. cinerea, and S. parviflora extracts were, therefore, evaluated for their inhibitory activities of TNF-α and IL-1β production, and NF-κB nuclear translocation in THP-1 macrophages. The HPLC analysis was carried out to elucidate and to compare the composition of these extracts. Major compounds of the tested extracts have been isolated using different chromatographic techniques and further tested for their inhibitory activities on TNF-α and IL-1β production. Several extracts showed promising anti-inflammatory activity in these in vitro tests. Results of HPLC analysis revealed chlorogenic acid as a compound present in all tested extracts. Hyperoside, quercetin-3-O-β-D-glucoside and rutin were also present in varying amount in some Scorzonera species analyzed. Furthermore, eight phenolics which were identified as quercetin-3-O-β-D-glucoside (1), hyperoside (2), hydrangenol-8-O-glucoside (3), swertisin (4), 7-methylisoorientin (5), 4,5-O-dicaffeoyl-quinic acid (6), 3,5-di-O-caffeoyl-quinic acid (7), and chlorogenic acid (8) have been isolated as major phenolic compounds of the tested extracts and, together with eight terpenoids (9-16) previously obtained from different Scorzonera species, have been tested for the inhibition of TNF-α production, unfortunately with no activity comparable with standard.

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Section: Resultsmentioning

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Hplc Analysismentioning

confidence: 99%

See 2 more Smart Citations

Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-κB Activation, Showing Anti-Inflammatory Effect in Vitro

et al. 2015

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“…szowitsii, S. suberosa ssp. suberosa were proven scientifically by previous studies and triterpenoids were isolated as responsible compounds [3][4][5] . Antiinflammatory, antioxidant, and wound healing activities have also been reported [6][7][8][9] .…”

Section: Research Papermentioning

confidence: 99%

Preclinical Evaluation of Scorzonera sp. Root Extracts and Major Compounds Against Acute Hepatotoxicity Induced by Carbon Tetrachloride

Acikara¹,

Yigitbasi²,

Sakul³

et al. 2017

pharmaceutical-sciences

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Evaluation of hepatoprotective activities of Scorzonera roots and their major compounds, was aimed in current study. Scorzonera latifolia, S. tomentosa, S. mollis ssp. szowitsii, S. parviflora and S. cana var. jacquiniana roots, methanol-water (80:20) extracts together with chlorogenic acid, scorzotomentosin-4'-O-β-glucoside, hydrangenol-8-O-β-glucoside as major compounds isolated from S. latifolia roots were tested for their hepatoprotective activities. Sprague Dawley rats were used for experiment and hepatotoxicity was induced by carbon tetrachloride. Aspartate aminotransferase and alanine aminotransferase levels were measured and all results were confirmed by histopathological examination. Plasma aspartate aminotransferase and alanine aminotransferase levels of examined groups were not significant when compared to carbon tetrachloride-treated groups. However histopathological results have revealed that all tested groups have less damage when compared to carbon tetrachloride group except scorzotomentosin-4'-O-β-glucoside and hydrangenol-8-O-β-glucoside groups. Scorzonera species displayed moderate hepatoprotective activities against carbon tetrachloride induced acute toxicity. Chlorogenic acid, among tested compounds exhibited higher activity than all tested Scorzonera species as well as other isolated compounds. Therefore chlorogenic acid could be suggested as responsible compound.

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Assessment of Correlation Analysis, Phytochemical Profile, and Biological Activities of EndemicScorzoneraSpecies from Turkey

Sarıaltın

Açıkara

2022

Chemistry & Biodiversity

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Scorzonera species belong to the Asteraceae family comprising more than 25000 species. The present study aimed to examine the phytochemical profiles and biological activities of S. sandrasica Hartvig et Strid, S. coriacea A. Duran&Aksoy, and S. ahmet-duranii Makbul&Coskuncelebi which are endemic species to Turkey. Flavonoids such as hyperoside, isoquercitrin, rutin, isoorientin, orientin, 7-O-methyl isoorientin, luteolin-7-O-β-glycoside, apigenin-7-O-β-glucoside, vitexin, isovitexin as well as caffeoylquinic acid derivatives including chlorogenic acid, 4,5-O-dicaffeoylquinic acid, and 1,5-O-dicaffeoylquinic acid contents were analyzed to clarify phytochemical content of the extracts. Aerial parts of the investigated extracts were determined as contain flavonoids in high amounts. Chlorogenic acid and its derivatives were detected in all investigated species, in varying amounts, both in the roots and aerial parts. S. coriacea aerial parts contained the highest total phenolic and flavonoids. The strongest inhibitory activities on ABTS and DPPH radicals were also observed with S. coriacea aerial parts by 8.07 � 0.28 and 13.94 � 0.53 μg/ml of IC 50 values, respectively. Total phenolic contents of the extracts were significantly correlated with DPPH (r = À 0.9842, p = 0.0004) and ABTS free radical scavenging (r = À 0.9870, p = 0.0003) and total antioxidant capacity (r = 0.8173, p = 0.0470), as well as total flavonoid contents (r = 0.8820, p = 0.0201). S. sandrasica aerial parts and S. ahmet-duranii roots exhibited the greatest red blood cell membrane protection and protein denaturation inhibition, respectively. From the phytochemical point of view, all the selected species were analyzed for the first time.

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Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC.

Cited by 28 publications

References 22 publications

Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-κB Activation, Showing Anti-Inflammatory Effect in Vitro

Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-κB Activation, Showing Anti-Inflammatory Effect in Vitro

Preclinical Evaluation of Scorzonera sp. Root Extracts and Major Compounds Against Acute Hepatotoxicity Induced by Carbon Tetrachloride

Assessment of Correlation Analysis, Phytochemical Profile, and Biological Activities of EndemicScorzoneraSpecies from Turkey

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