Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents

Ezeonwumelu, Joseph Obiezu Chukwujekwu; Ntale, Muhammad; Ogbonnia, Steve; Agwu, Ezera; Tanayen, Julius Kihdze; Adedeji, A. A.; Okonkwo, C. O.; Akunne, Ambrose Amamchukwu; Ebosie, Jennifer Chibuogwu; Byarugaba, Frederick

doi:10.4236/pp.2018.96014

Cited by 8 publications

(13 citation statements)

References 47 publications

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“…Medicinally, they are known as stimulants, local anesthetics, anti-bacterial, anti-hypertensive and analgesics. This explains the use of B. pilosa in the treatment of headaches and pains 17 .…”

Section: Discussionmentioning

confidence: 93%

Antimicrobial and GC-MS Analyses of Stem and Root Extracts of Bidens pilosa Linn

et al. 2019

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This study describes the qualitative phytochemical screening, antimicrobial and GC-MS analyses of the crude methanol extract of the stem and roots parts of Bidens pilosa partitioned between methanol, dichloromethane, ethyl acetate and hexane solvents. Phytochemical analysis indicated the presence of cardiac glycosides, terpenoids, flavonoids and alkaloids. Saponins were not found in any of the fractions of stem and root of B. pilosa. Antibacterial studies indicated that the lowest concentration (6.25 mg/mL) was achieved for Candida subtilis for the ethyl acetate fraction of the stem extract and hexane fraction of the root extract. Antimycobacterial test activity of these solvent fractions revealed that the hexane fraction of the root extract was susceptible to the bacterium isolate. Gas chromatography-Mass spectrometric study revealed the presence of the following compounds - cis-9-Hexadecenal, 2-hydroxyl ethyl (Z)-9-Octadecenoate, Octadecanal, Oleic acid, 4-(dimethylamino)-Benzaldehyde, 4,6,7-Trimethoxy-2,3-dihydrofuro(2,3-b)quinolone.

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Section: Discussionmentioning

confidence: 93%

Antimicrobial and GC-MS Analyses of Stem and Root Extracts of Bidens pilosa Linn

et al. 2019

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“…The aqueous extract of B. pilosa contains polyacetylenes; flavonoids; flavonols; terpenoids; tannins; phlobatannins; alkaloids; saponins; steroids; sterols; cardiac glycosides; Phenol, 2, 4-Bis (1, 1-Dimethylethyl) and other phenolic compounds [18,35,29,36]. These compounds might play a role in the activities of the extracts, such as antimicrobial activity against Gram-positive and negative bacteria [29], analgesic activity [18]; anti-inflammatory [5]; hepatoprotective activity [37]; anti-plasmodial activity, [35]; anti-obesity [36]; and alleviate the dry-eye symptoms [20].…”

Section: Bioactive Compounds Of B Pilosa Plant Partsmentioning

confidence: 99%

“…The properties are no longer folklores because many studies have been proven the activities in vitro, in vivo, and ex vivo assays [3,7,9,[12][13][14][15][16][17][18][19][20][21][22][23]. Currently, the plant become a market commodity, such as dried plant powder, B. pilosa tea, extracts, and tinctures.…”

Section: Introductionmentioning

confidence: 99%

Bidens pilosa Linn.: Beautiful Weed for the Healthy Mouth – A Mini Review

et al. 2023

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Bidens pilosa L. can be found everywhere in warm and humid regions. The plant has been used as a food and drink supplement, and as medicinal herbs for a long time by people from various places. The assortment of activities of B. pilosa in treating diseases gives a remarkable possibility to explore and develop its utilization for various medicinal purposes. In this mini-review, we explored the application of B. spilosa as herbal medicine for mouth health, specifically mouthwash. Until now, there is no information about the application of this plant for mouthwash. The use of alcohol, cetyl pyridinium, chlorhexidine, and triclosan as active ingredients in mouthwash can control plaque. However, the long-term use of these compounds may show side effects, for instance, changes in taste, and teeth and oral stains. Based on the result, it can be concluded that the B. spilosa plant contains diverse groups of compounds, such as polyacetylenes, flavonoids, and tannins, which are responsible for its various activities. The B. spilosa extracts are non-toxic and have potential active compounds in mouthwash formulation, due to their antimicrobial action against a wide range of microbes, particularly oral microbes and it has additional activities such as anti-inflammation, analgesic, and antioxidant.

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“…Some traditional plants used for the treatment of pain also have one or more of these metabolites. Compounds, such as tannins, anacardial acid present in extracts of Anacardium occidentale L [ 174 ], eugenol and linalol identified in extracts of Bidens Pilosa [ 175 , 176 ], camphor and linalool from Piper aduncum extracts [ 177 , 178 ], and carvone and geraniol from Lippia alba [ 179 ], may be involved in the potential analgesic effects of these extracts [ 174 , 180 , 181 ]. However, further studies are required to elucidate the mechanisms mediating the observed effects [ 181 ].…”

Section: The Role Of Trp Channel Agonists and Antagonists In Cancer Painmentioning

confidence: 99%

TRP Channels as Molecular Targets to Relieve Cancer Pain

et al. 2021

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Transient receptor potential (TRP) channels are critical receptors in the transduction of nociceptive stimuli. The microenvironment of diverse types of cancer releases substances, including growth factors, neurotransmitters, and inflammatory mediators, which modulate the activity of TRPs through the regulation of intracellular signaling pathways. The modulation of TRP channels is associated with the peripheral sensitization observed in patients with cancer, which results in mild noxious sensory stimuli being perceived as hyperalgesia and allodynia. Secondary metabolites derived from plant extracts can induce the activation, blocking, and desensitization of TRP channels. Thus, these compounds could act as potential therapeutic agents, as their antinociceptive properties could be beneficial in relieving cancer-derived pain. In this review, we will summarize the role of TRPV1 and TRPA1 in pain associated with cancer and discuss molecules that have been reported to modulate these channels, focusing particularly on the mechanisms of channel activation associated with molecules released in the tumor microenvironment.

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Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents

Cited by 8 publications

References 47 publications

Antimicrobial and GC-MS Analyses of Stem and Root Extracts of Bidens pilosa Linn

Antimicrobial and GC-MS Analyses of Stem and Root Extracts of Bidens pilosa Linn

Bidens pilosa Linn.: Beautiful Weed for the Healthy Mouth – A Mini Review

TRP Channels as Molecular Targets to Relieve Cancer Pain

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