Analgesic, anti-inflammatory and antipyretic activities of methanolic leaf extract of Maerua crassifolia

Akuodor, Godwin Christian; Essien, A; Akpan, Joseph Linus; Chilaka, Kingsley Chimsorom; Jane, Nkemjika; Uwaezuoke, Ikodiya; Nwadike, KI; Nwobodo, Ndubuisi N.; Ezeokpo, Basil Chukwuma

doi:10.12980/jclm.4.2016j5-153

Cited by 5 publications

(8 citation statements)

References 24 publications

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“…The extract reduced the xyleneinduced ear oedema in mice and the activities exhibited by the extract were comparable to those exhibited by the positive control. On carrageenan-induced paw oedema, the extract exhibited dose-dependent activities and these activities were comparable to those exhibited by the positive control [61].…”

Section: Anti-inflammatory Activitiessupporting

confidence: 52%

“…Some researchers identified nutritional elements and phytochemical compounds from the aerial parts and leaves of M. crassifolia and these include alkaloids, amino acids, betaines, fatty acids, flavonoids, lignan glucosides, phenolics, tannins, nutritional compounds, quaternary ammonium compounds, minor and major elements (Table 2). Other phytochemical compounds identified from the leaves of M. crassifolia include cardiac glycosides, phenols, resins, saponins, steroids and terpenoids [59][60][61].…”

Section: Nutritional and Phytochemistrymentioning

confidence: 99%

“…Akuodor et al [61] evaluated the analgesic activities of the methanol leaf extract of M. crassifolia in Albino mice using the acetic acid-induced writhing and tail immersion methods. The extract at doses of 100.0, 200.0 and 400.0 mg/kg exhibited dose-dependent inhibition of pain in acetic acid-induced writhing and tail immersion tests [61].…”

Section: Analgesic Activitiesmentioning

confidence: 99%

“…Akuodor et al [61] evaluated the anti-inflammatory activities of the methanol leaf extract of M. crassifolia in Albino mice and rats using the xylene and carrageenan-induced paw oedema methods with aspirin (150.0 mg/kg) and dexamethasone (4.0 mg/kg) as positive controls. The extract reduced the xyleneinduced ear oedema in mice and the activities exhibited by the extract were comparable to those exhibited by the positive control.…”

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

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A Synthesis and Review of Medicinal uses, Phytochemistry and Pharmacological Properties of Maerua crassifolia Forssk. (Capparaceae)

Maroyi

2020

J. Pharm. Nutr. Sci.

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Maerua crassifolia Forssk. is an evergreen tree widely used as traditional medicine throughout its distributional range in the Sahel region, peninsular Arabia east to Pakistan, east and west Africa. This study is aimed at providing a critical review of medicinal uses, phytochemical and pharmacological properties of M. crassifolia. Documented information on medicinal uses, phytochemical and pharmacological properties of M. crassifolia was collected from several online sources such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. The articles published between 1964 and 2020 were used in this study. This study revealed that the bark, fruit, leaf and twig infusion and/or decoction of M. crassifolia are mainly used as ethnoveterinary medicine, and traditional medicine for cephalalgia, headache, fever, malaria, wounds, skin infections, toothache and gastro-intestinal problems. Phytochemical compounds identified from the species include alkaloids, amino acids, betaines, cardiac glycosides, fatty acids, flavonoids, lignan glucosides, phenolics, quaternary ammonium compounds, saponins, steroids, tannins and terpenoids. The M. crassifolia extracts exhibited antibacterial, anti-diarrhoeal, analgesic, anti-inflammatory, antioxidant, antiplasmodial, antiprotozoal, antitrypanosomal, antipyretic and cytotoxicity activities. Maerua crassifolia should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.

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Section: Anti-inflammatory Activitiessupporting

confidence: 52%

Section: Nutritional and Phytochemistrymentioning

confidence: 99%

Section: Analgesic Activitiesmentioning

confidence: 99%

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

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A Synthesis and Review of Medicinal uses, Phytochemistry and Pharmacological Properties of Maerua crassifolia Forssk. (Capparaceae)

Maroyi

2020

J. Pharm. Nutr. Sci.

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“…In traditional medicine, the leaves are used for the treatment of some diseases including analgesic, anti-inflammatory, antipyretic, antibacterial and antioxidant, antimalarial, Phytochemical and antidiarrhoea Chilaka et al, 2015;Akuodor et al, 2014a;Akuodor et al, 2014d). In other pharmacological studies, the leaf extract has shown to have effects against gastrointestinal and toothache diseases (Rahman et al, 2004;Idris-Usman et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Haematological and biochemical changes after exposure to Maerua crassifolia ethanol leaf extract in rats

2017

J App Pharm Sci

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This study was carried out to determine the safety profile of Maerua crassifolia by conducting the acute and subacute toxicological assay of its ethanol leaf extract in rats. The animals were treated daily with the leaf extract at doses of 100, 200 and 400 mg/kg orally for 14 and 28 days. Rats used as control were given distilled water and all rats weighed every 7 days. After the test, haematological and biochemical parameters as well as their relative organs weight were determined. There were no significant changes in body weight of treated animals compared to control in both studies. In the acute toxicity test, the extract did not cause any signs of toxicity or produce mortality in rats. Subacute results showed that oral administration of the leaf extract did not significantly (p<0.05 affect their food consumption, haematological and biochemical parameters and relative organs weight. Findings in this study showed that Maerua crassifolia is endowed with the potential beneficial effects as immune booster and protecting the liver and kidney systems.

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Development of an Efficient and Rapid Micropropagation Protocol for In Vitro Multiplication of Maerua crassifolia Forssk

Alatar

Qahtan

Abdel-Salam

et al. 2023

Forests

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The difficult propagation of shrub and tree species and their extensive exposure to grazing threaten their abundance and lead to the necessity to find alternative means of propagation for these species. In vitro micropropagation techniques, viz., tissue culture, offer a promising tool for the rapid, cost-effective, and efficient propagation of different plant species. In the current study, a rapid and efficient in vitro multiplication protocol was developed for the micropropagation of Maerua crassifolia Forssk. Our results revealed that Murashige and Skoog (MS) medium with 7.5 µM of 6-benzylaminopurine (BA) and 1.0 µM of 1-naphthaleneacetic acid (NAA) led to the highest shoot formation (13.9 shoots per explant in 85.7% of the cultivated hypocotyls) among all other treatments. The best in vitro root formation was obtained on half-strength MS medium with 1.0 µM of indole 3-butyric acid (IBA) as 94.1% of the cultivated shoots formed 6.8 roots per microshoot on average. Ninety percent of the rooted plantlets were successfully acclimatized and are currently growing in the botanical garden of the Botany and Microbiology Department, King Saud University, Riyadh, Saudi Arabia. The genetic fidelity of the micropropagated plants was authenticated via flow cytometry. The results of the current study explained a simple, cost-effective, and efficient protocol for the micropropagation of the endangered M. crassifolia trees.

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Analgesic, anti-inflammatory and antipyretic activities of methanolic leaf extract of Maerua crassifolia

Cited by 5 publications

References 24 publications

A Synthesis and Review of Medicinal uses, Phytochemistry and Pharmacological Properties of Maerua crassifolia Forssk. (Capparaceae)

A Synthesis and Review of Medicinal uses, Phytochemistry and Pharmacological Properties of Maerua crassifolia Forssk. (Capparaceae)

Haematological and biochemical changes after exposure to Maerua crassifolia ethanol leaf extract in rats

Development of an Efficient and Rapid Micropropagation Protocol for In Vitro Multiplication of Maerua crassifolia Forssk

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