Analgesic, Anti-diarrheal, CNS-depressant, Membrane Stabilizing and Cytotoxic Activities of Canavalia virosa (Roxb.) W&A

Abstract

The methanol extract of the leaves of Canavalia virosa (Roxb.) W&A was investigated for the evaluation of analgesic, anti-diarrheal and CNS-depressant activities in Swiss albino mice. The analgesic activity was assessed by formalin-induced paw licking method, where the crude extract of C. virosa (400 mg/kg, b.w.) exhibited 41.46% reduction of licking response in mice as compared to 73.17% reduction exhibited by standard acetylsalicylic acid. In the castor oil-induced diarrhea in mice, the plant extract at the dose of 200 mg/kg, b.w., demonstrated 56% reduction of diarrheal feces in mice, while the standard loperamide revealed 76% reduction of diarrheal feces. The CNS-depressant activity of the plant extract was assessed through phenobarbitone-Na induced sleeping time test. The methanol extract of C. virosa and its different Kupchan fractions were also subjected to screen membrane stabilizing and cytotoxic activities using acetylsalicylic acid and vincristine sulphate as standard, respectively.
 Bangladesh Pharmaceutical Journal 22(2): 214-218, 2019

Isolation, characterization and pharmacological potentials of methanol extract of Cassia fistula leaves: Evidenced from mice model along with molecular docking analysis

“…Modern drug design increasingly uses computational methods to evaluate pharmacokinetics (including Absorption, drug-likeness, distribution, metabolism, excretion, and toxicity) and pharmacokinetic assessments. These studies, collectively known as ADMET, are crucial to developing new drugs [ 2 ].…”

“…Plants represent the most abundant source of many wonderful drugs since the inception of humankind and always offer any type of novel treatments [ [1] , [2] , [3] , [4] , [5] ]. Rigorous laboratory experiments are usually done to justify natural products useful for specific human illnesses [ 6 , 7 ].…”