Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts

Ntandou, G.F. Nsonde; Banzouzi, J.T.; M’Batchi, Bertrand; Elion-Itou, R. D. G.; Etou-Ossibi, A. W.; Ramos, Suzanne; Benoit‐Vical, Françoise; Abena, A. A.; Ouamba, J. M.

doi:10.1016/j.jep.2009.09.040

Cited by 77 publications

(20 citation statements)

References 28 publications

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“…29–31 Emodin (1,3,8-trihydroxy-6-methylanthracene-9,10-dione), which is found in many plants, 32,33 has been shown to have a variety of therapeutic effects, such as anti-inflammatory 34 and antidiabetic effects in mouse models. 35–37 While one study showed AR inhibitory activity of emodin in vitro , 38 detailed studies of emodin as a therapeutic agent against diabetic eye disease have not been reported.…”

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confidence: 99%

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract

Chang

Sanborn

et al. 2016

J. Nat. Prod.

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Aldose reductase (AR) in the lens plays an important role in the pathogenesis of diabetic cataract (DC) by contributing to osmotic and oxidative stress associated with accelerated glucose metabolism through the polyol pathway. Therefore, inhibition of AR in the lens may hold the key to prevent DC formation. Emodin, a bioactive compound isolated from plants, has been implicated as a therapy for diabetes. However, its inhibitory activity against AR remains unclear. Our results showed that emodin has good selectively inhibitory activity against AR (IC50 = 2.69 ± 0.90 μM) but not other aldo-keto reductases and is stable at 37 °C for at least 7 days. Enzyme kinetic studies demonstrated an uncompetitive inhibition against AR with a corresponding inhibition constant of 2.113 ± 0.095 μM. In in vivo studies, oral administration of emodin reduced the incidence and severity of morphological markers of cataract in lenses of AR transgenic mice. Computational modeling of the AR–NADP–emodin ternary complex indicated that the 3-hydroxy group of emodin plays an essential role by interacting with Ser302 through hydrogen bonding in the specificity pocket of AR. All the findings above provide encouraging evidence for emodin as a potential therapeutic agent to prevent cataract in diabetic patients.

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confidence: 99%

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract

Chang

Sanborn

et al. 2016

J. Nat. Prod.

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“…It exhibited stronger antinociceptive properties than acetyl salicylic acid, acetaminophen, dipyrone and indomethacin (Block et al, 1998). Again, Cassia siamea Lam extract revealed noteworthy analgesic effect in hot plate assay, in which the flavonoid, luteolin had contributed to the extract's analgesic potential (Nsonde et al, 2010). On the other hand, kaempferol 3-O-sophoroside revealed analgesic activity in tail clip, tail flick, tail immersion and acetic acidinduced writhing methods (Palanichamya and Nagarajan, 1990).…”

Section: Discussionmentioning

confidence: 97%

Bioactivities of stem bark of Albizia chinensis Osbeck. Merr., Chakua Koroi of Bangladesh

Sharmin¹,

Mohammad²

2020

Afr. J. Pharm. Pharmacol.

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Albizia chinensis Osbeck. Merr. (Family: Fabaceae) is quite abundant in Bangladesh. The plant has a history of its traditional use in scorpion and snake bite. This investigation was designed to analyze the analgesic, anti-diarrheal and anti-inflammatory potentials along with sleep inducing property of the crude methanol extract of stem bark of Albizia chinensis Osbeck. Merr. Peripheral analgesic activity was evaluated by inducing pain through intraperitoneal administration of acetic acid in writhing test. Tail-flick test protocol was followed to determine central analgesic activity. The tail flicking response to thermal stimulus was measured in this assay. A. chinensis extract was also tested for anti-diarrheal activity by inducing castor oil-induced diarrhea in Swiss albino mice model. Phenobarbitone-sodium induced sleeping time was determined to assess CNS depressant activity. The crude methanol extract (400 mg/kg body weight) demonstrated 85.71% inhibition of writhing as compared to 74.49% by diclofenac sodium. The crude extract (400 mg/kg dose) reduced diarrheal feces by 69.05% and revealed 53.03% elongation of the reaction time after 30 min of administration in tail flick test. At the same dose, the crude methanol extract exhibited 91.49% inhibition of rat paw edema at the 4 th h of carrageenan injection. The phytocomponents responsible for observed activity should be isolated and involved in further assessment.

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“…The pain is induced by the pressure exerted on the hind paw of animals by the analgesymeter [11]- [14]. One 1hour after oral administration of the tested products, nociceptive thresholds were determined using the analgesymeter.…”

Section: Analgesymeter Induced Pain Experimentsmentioning

confidence: 99%

Anti-Inflammatory and Analgesic Effects of Aqueous Extract of Stem Bark of <i>Ceiba pentandra</i> Gaertn

Itou¹,

Sanogo²,

Ossibi³

et al. 2014

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Anti-inflammatory and analgesic effects of the aqueous extract of the stem bark of Ceiba pentandra Gaertn (Bombacaceae) were recorded in rat and mice. Inflammation was induced by carrageenan and cotton pellet. The pain was studied using analgesymeter, Koster and hot plate Methods. Aqueous extract (400 and 800 mg/kg) of Ceiba pentandra presents a significant anti-inflammatory and analgesic activity. Flavonoïds present in the extract seem to be responsible for the activity.

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Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts

Cited by 77 publications

References 28 publications

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract

Bioactivities of stem bark of Albizia chinensis Osbeck. Merr., Chakua Koroi of Bangladesh

Anti-Inflammatory and Analgesic Effects of Aqueous Extract of Stem Bark of <i>Ceiba pentandra</i> Gaertn

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Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts

Cited by 77 publications

References 28 publications

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract

Bioactivities of stem bark of Albizia chinensis Osbeck. Merr., Chakua Koroi of Bangladesh

Anti-Inflammatory and Analgesic Effects of Aqueous Extract of Stem Bark of &lt;i&gt;Ceiba pentandra&lt;/i&gt; Gaertn

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Anti-Inflammatory and Analgesic Effects of Aqueous Extract of Stem Bark of <i>Ceiba pentandra</i> Gaertn