Analgesic and Anti-Inflammatory Activity of Vanillin Derivatives

Boiko, Yurii; Nesterkina, Mariia; Шандра, А. А.; Kravchenko, Iryna

doi:10.1007/s11094-019-02056-2

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…The activation of TRPV1 triggers the influx of Ca 2+ , which leads to a series of events related to pain transmission, including membrane depolarization, neuronal discharge, and release of pain transmitters (Aghazadeh Tabrizi et al., 2017). However, the continuous activation of the channel leads to high intracellular Ca 2+ level, which eventually leads to desensitization or deactivation to various harmful stimuli by changing the function and morphology of the peripheral end of nerve fibers, thus relieving pain (Boiko et al., 2019).…”

Section: Biological Activity Of Capsaicin Derivativesmentioning

confidence: 99%

Capsaicin derivatives: Synthesis and biological activity

Liu,

Zheng,

et al. 2024

Chem Biol Drug Des

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Capsaicin is the main active ingredient of chili peppers and the most pungent alkaloid. It is reported that capsaicin has many pharmacological effects such as analgesia, anticancer, anti‐inflammatory, antibacterial, and anti‐obesity. However, the application of capsaicin is limited by its adverse side effects, such as stomach irritation, stomach cramps, and burning sensation. In recent years, many capsaicin derivatives have been synthesized and their biological activities have been evaluated. Some capsaicin derivatives have shown promising activities in cells and animal models. Herein, we described the synthesis and biological activity of capsaicin and its derivatives. It is hoped that the insights obtained in this perspective will facilitate the synthesis of a second generation of capsaicin analogs with improved biological activities.

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Section: Biological Activity Of Capsaicin Derivativesmentioning

confidence: 99%

Capsaicin derivatives: Synthesis and biological activity

Liu,

Zheng,

et al. 2024

Chem Biol Drug Des

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“…Vanillin oxime ( 9 ) is a compound that has been shown different activities like anti-inflammatory, 18 antifungal, 19 antimicrobial and antioxidant. 20 Vanillin oxime was synthesized from compound 4 , which was transformed to vanillin ( 8 ) by the deprotection of the ester function to alcohol in one and simple step in good yield.…”

Section: Protection Of Eugenolmentioning

confidence: 99%

Oxidation of Eugenol Derivatives with KMnO4 and CrO3

Abdou,

Dakir,

Maaghloud

et al. 2024

Synthesis

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This study aims to delineate the synthesis of eugenol derivatives, starting with hydroxyl group protection and then the subsequent oxidation stages. Initially, eugenol underwent conversion into acetyleugenol and benzyleugenol during the protection phase. Subsequently, a kinetic oxidation of acetyleugenol with KMnO4 via GC-MS analysis resulted in the identification of four compounds. The kinetic investigation indicated the primary formation of diolacetyleugenol, succeeded by aldehyde eugenol, which further gets converted into its respective carboxylic acid. Additionally, acetyleugenol and benzyleugenol underwent oxidation with CrO3, yielding the corresponding carboxylic acids.

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