Analgesic and anti-inflammatory activities of [6]-gingerol

Young, Haw-Yaw; Luo, Yen-Lin; Cheng, Hao-Yuan; Hsieh, Wen-Chiuan; Liao, Jung-Chun; Peng, Wen-Huang

doi:10.1016/j.jep.2004.09.009

Cited by 291 publications

(228 citation statements)

References 18 publications

(17 reference statements)

Supporting

Mentioning

212

Contrasting

Unclassified

Order By: Relevance

“…27 Previous studies showed that ginger ameliorated cisplatin-induced nephrotoxicity either by preventing cisplatin-induced decline of renal antioxidant defense system or by its direct free radical scavenging activity. 28 It was also proved that ginger exhibits antiinflammatory effects, 29 which give a good rationale for significant decrease in serum CRP levels observed in our study. Significant decreases in serum CRP levels are confirmed by recent studies in which [6]-gingerol is endowed with strong anti-inflammatory and antiapoptotic actions.…”

Section: Discussionsupporting

confidence: 71%

Evaluation of the Efficacy of Ginger, Arabic Gum, andBoswelliain Acute and Chronic Renal Failure

2011

View full text Add to dashboard Cite

This study was conducted to evaluate the effects of Zingiber officinale Roscoe (Ginger), Arabic gum (AG), and Boswellia on both acute and chronic renal failure (CRF) and the mechanisms underlying their effects. Acute renal failure was induced by 30 min ischemia followed by 24 h reperfusion, while CRF was induced by adenine feeding for 8 weeks. Prophylactic oral administration of ginger, AG, Boswellia, or vehicle (in control groups) was started 3 days before and along with adenine feeding in different groups or 7 days before ischemia-reperfusion. Ginger and AG showed renoprotective effects in both models of renal failure. These protective effects may be attributed at least in part to their anti-inflammatory properties as evident by attenuating serum C-reactive protein levels and antioxidant effects as evident by attenuating lipid peroxidation marker, malondialdehyde levels, and increasing renal superoxide dismutase activity. Ginger was more potent than AG in both models of renal failure. However, Boswellia showed only partial protective effect against both acute renal failure and CRF and it had no antioxidant effects. Finally, we can say that ginger and AG could be beneficial adjuvant therapy in patients with acute renal failure and CRF to prevent disease progression and delay the need for renal replacement therapy.

show abstract

Section: Discussionsupporting

confidence: 71%

Evaluation of the Efficacy of Ginger, Arabic Gum, andBoswelliain Acute and Chronic Renal Failure

2011

View full text Add to dashboard Cite

show abstract

“…Edema formation in the paw is the result of a synergism between various inflammatory mediators that increased vascular perme ability and blood flow. 33 However, pretreatment with ELEVA extracts showed a significant inhibition in the late phase of formalin induced pain in a dose dependent manner which was well comparable with the standard drug indomethacin and also corroborates with the find ings of Young et al (2005). 34 Recently, it has been shown that faulty cellular antioxidant systems cause organisms to develop a series of inflam matory and cancer diseases.…”

Section: Discussionsupporting

confidence: 71%

“…33 However, pretreatment with ELEVA extracts showed a significant inhibition in the late phase of formalin induced pain in a dose dependent manner which was well comparable with the standard drug indomethacin and also corroborates with the find ings of Young et al (2005). 34 Recently, it has been shown that faulty cellular antioxidant systems cause organisms to develop a series of inflam matory and cancer diseases. 35 The present study also demonstrated a cumulative decrease in the levels of anti oxidant enzymes and considerable increase in the levels of lipid peroxide which is well indicative of tissue damage on induction of formalin in experimental animals.…”

Section: Discussionsupporting

confidence: 71%

Anti-inflammatory screening of ethanolic leaf extract of Vernonia arborea Buch. –Ham.in formalin induced albino wistar rats

Sridharan¹,

Venkatramani²,

Janakiraman³

et al. 2016

IJPER

View full text Add to dashboard Cite

Context:The therapeutic potential of the genus Vernonia has been well documented over the years. However the pharmacological potential of the plant Vernonia arborea (Asteraceae) has been relatively less explored. Objective: To investigate the antiinflammatory effect of the ethanol leaf extract of V. arborea against formalin induced inflammation in rats. Materials and methods: Formalin induced inflammation method was used to induce inflammation in rats.0.1 ml/kg body weight (b.w.) of formalin was administered to the rats via sub-plantar injection to induce inflammation. The rats were pretreated with ethanol leaf extract of V. arborea at concentrations of 100, 200 and 300 mg/kg b.w. once daily for 30 days. Indomethacin (25 mg/kg b.w.) was used as standard drug. Biochemical and hematological parameters along with levels of antioxidant enzymes were evaluated. Results: Administration of formalin reduced antioxidant enzyme levels, total RBC and Hb. Pretreatment with ethanol leaf extract of V.arborea at dose dependent levels significantly increased (p<0.05)the levels of the above parameters. A significant increase (p<0.05) in paw thickness, level of serum enzymes (Aspartate transaminase, Alanine transaminase, Alkaline phosphatase and Creatine kinase), Lipid peroxide and leucocytes was observed in the rats induced with formalin, while these levels were normalized on pretreatment with ethanol leaf extract of V.arborea. Conclusion: The results of the present investigation demonstrate the antioxidant and anti-inflammatory potential of the ethanol leaf extract of V.arborea. However, it is imperative to isolate and purify the active principles involved in the pharmacological potency of this plant and determine its mechanism of action.

show abstract

“…The pharmacological properties of gingerols include antioxidant, analgesic and anti-inflammatory [6] , antipyretic [7] , cardiotonic [8] , and hypothermic [9] activities. More recent studies have suggested that gingerols exhibit preventive activity against cancers of the skin [10] , pancreas [11] , gastrointestinal tract [12] , colon [13] , and breast [14] .…”

Section: Introductionmentioning

confidence: 99%

Pungent ginger components modulates human cytochrome P450 enzymes in vitro

Chen

Yue

et al. 2013

Acta Pharmacol Sin

View full text Add to dashboard Cite

Aim: Ginger rhizome is used worldwide as a spicy flavor agent. This study was designed to explore the potential effects of pungent ginger components, 6-, 8-, and 10-gingerol, on human cytochrome P450 (CYP450) enzymes that are responsible for the metabolism of many prescription drugs. Methods: The activities of human CYP2C9, CYP2C19, CYP2D6, and CYP3A4 were analyzed using Vivid P450 assay kits. The mRNA expression of CYP3A4 in human hepatocellular carcinoma cell line HepG2 was measured using quantitative real-time PCR assay. Results: All three gingerols potently inhibited CYP2C9 activity, exerted moderate inhibition on CYP2C19 and CYP3A4, and weak inhibion on CYP2D6. 8-Gingerol was the most potent in inhibition of P450 enzymes with IC 50 values of 6.8, 12.5, 8.7, and 42.7 μmol/L for CYP2C9, CYP2C19, CYP3A4, and CYP2D6, respectively. By comparing the effects of gingerols on CYP3A4 with three different fluorescent substrate probes, it was demonstrated that the inhibition of gingerols on CYP3A4 had no substrate-dependence. In HepG2 cells, 8-gingerol and 10-gingerol inhibited, but 6-gingerol induced mRNA expression of CYP3A4. Conclusion: 6-, 8-, and 10-gingerol suppress human cytochrome P450 activity, while 8-and 10-gingerol inhibit CYP3A4 expression. The results may have an implication for the use of ginger or ginger products when combined with therapeutic drugs that are metabolized by cytochrome P450 enzymes.

show abstract

Analgesic and anti-inflammatory activities of [6]-gingerol

Cited by 291 publications

References 18 publications

Evaluation of the Efficacy of Ginger, Arabic Gum, andBoswelliain Acute and Chronic Renal Failure

Evaluation of the Efficacy of Ginger, Arabic Gum, andBoswelliain Acute and Chronic Renal Failure

Anti-inflammatory screening of ethanolic leaf extract of Vernonia arborea Buch. –Ham.in formalin induced albino wistar rats

Pungent ginger components modulates human cytochrome P450 enzymes in vitro

Contact Info

Product

Resources

About