Analgesic and Anti-inflammatory Activities ofBoswellia elongata balfMethanolic Extracts, as Endemic Plants in Yemen

Alwashli, Ahmed; Al-Sobarry, Mosa’d; Alnamer, Rachad; Cherrah, Yahia; Alaoui, Katim

doi:10.1080/22311866.2012.10719114

Cited by 10 publications

(15 citation statements)

References 25 publications

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“…The significant anti-inflammatory effects shown by both the extract and the standard drug (Indomethacin 25 mg/kg) evidenced that their effects started in the early phase of inflammation by inhibiting endogenous inflammatory mediators such as serotonin and histamine as they involve in the early phase of inflammation, while the effects of edema inhibition reached maximum at the 4 th time suggests that both the extract and the standard drug have profound anti-inflammatory effects against various endogenous inflammatory mediators that involve in the late phase of inflammation such as, COX, different PG analogues, BK and/or leukotriene or they could have, free radical scavenging activities. 8,36 Formaldehyde-induced paw edema model is the wellknown model for the evaluation of anti-arthritic and antiinflammatory potentials of natural products in sub-acute phase of inflammation. Injection of 2% formalin v/v with distilled water subcutaneously in the palm of the mice in the 1 st and 3 rd days of observation produced progressive paw edema which was characterized by increased migration of leucocytes and phagocytes, infiltrations of neutrophils, macrophages and proliferation of fibroblasts into the surrounding of injured area.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Analgesic and Anti-Inflammatory Activities of 80% Methanol Root Extract of Echinops kebericho M. (Asteraceae)

Tadesse¹,

Birru²,

Adugna³

et al. 2020

JIR

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Background: Pain and inflammation are the major devastating health problems commonly treated with traditional medicinal plants in Ethiopia. Echinops kebericho M. (Asteraceae) is the one which is frequently used to treat pain and inflammation by traditional healers in Ethiopian folk medicine. However, the plant has not been scientifically evaluated for its traditionally claimed use. The present study aimed at the investigation of analgesic and anti-inflammatory activities of 80% methanol root extract of Echinops kebericho M. in mice model. Methods: Successive maceration was used as a method of extraction using solvents of increasing polarity: methanol and water. After extraction of the roots with 80% hydro methanol, the crude extract was evaluated for its peripheral and central analgesic activities using acetic acid-induced writhing test and hot plate method, respectively, while its antiinflammatory activity was evaluated using carrageenan-and formalin-induced paw edema. The extract was evaluated at 100, 200 and 400 mg/kg doses. The positive control groups were treated with ASA 150 mg/kg for writhing test, morphine 10 mg/kg for hot plat method, indomethacin 25 mg/kg and diclofenac 10 mg/kg for paw edema tests and vehicle, distilled water (10 mL/kg) treated mice were assigned as negative controls. All treatment administrations were performed orally. Results: E. kebericho extract at all test doses showed statistically significant antinociceptive activity in both chemicals-induced peripheral and thermal-induced central pain in a dose dependent manner (p < 0.01 and p < 0.001). The greater analgesic activity was observed by the maximum dose of the extract (400 mg/kg) in both acetic acids-induced writhing test (57.84%) and hot plate method (69.40%). The effect of the extract was also statistically significant (p < 0.01 and p < 0.001) in both carrageenan and formalin-induced paw edema in dose dependent manner. Greater edema inhibition was observed by the highest dose (400 mg/kg) in both observations with the respective percentage values of 70.00% and 79.87%, respectively. Conclusion: In general, the data obtained from the present study elucidated that the extract possessed a significant analgesic and anti-inflammatory activities and recommended for further studies.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Analgesic and Anti-Inflammatory Activities of 80% Methanol Root Extract of Echinops kebericho M. (Asteraceae)

Tadesse¹,

Birru²,

Adugna³

et al. 2020

JIR

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“…Inflammation is usually associated with pain as a secondary process resulting from the release of analgesic mediators: nonsteroidal anti-inflammatory drugs (NSAIDs), steroidal drugs, and immunosuppressant drugs, which have been used usually in the relief of inflammatory diseases by people around the world for a long time [9]. …”

Section: Introductionmentioning

confidence: 99%

In VivoPotential Anti-Inflammatory Activity ofMelissa officinalisL. Essential Oil

Bounihi

Hajjaj

Alnamer

et al. 2013

Advances in Pharmacological Sciences

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Melissa officinalis L. (Lamiaceae) had been reported in traditional Moroccan medicine to exhibit calming, antispasmodic, and strengthening heart effects. Therefore, this study is aimed at determining the anti-inflammatory activities of M. officinalis L. leaves. The effect of the essential oil of the leaves of this plant was investigated for anti-inflammatory properties by using carrageenan and experimental trauma-induced hind paw edema in rats. The essential oil extracted from leaves by hydrodistillation was characterized by means of gas chromatography-mass spectrometry (GC-MS). M. officinalis contained Nerol (30.44%), Citral (27.03%), Isopulegol (22.02%), Caryophyllene (2.29%), Caryophyllene oxide (1.24%), and Citronella (1.06%). Anti-inflammatory properties of oral administration of essential oil at the doses of 200, 400 mg/kg p.o., respectively, showed significant reduction and inhibition of edema with 61.76% and 70.58%, respectively, (P < 0.001) induced by carrageenan at 6 h when compared with control and standard drug (Indomethacin). On experimental trauma, M. officinalis L. essential oil showed pronounced reduction and inhibition of edema induced by carrageenan at 6 h at 200 and 400 mg/kg with 91.66% and 94.44%, respectively (P < 0.001). We can conclude that the essential oil of M. officinalis L. possesses potential anti-inflammatory activities, supporting the traditional application of this plant in treating various diseases associated with inflammation and pain.

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“…It is a healthy process resulting from some disturbances or disease and it is usually associated with pain as a secondary process resulting from the release of analgesic mediators: nonsteroidal anti-inlammatory drugs (NSAIDs), steroidal drugs, and immunosuppressant drugs, which have been used usually in the relief of inlammatory diseases by people around the world for a long time [9].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Potential Anti-Inflammatory Activity of Extracts from Calendula arvensis (CA) Flowers

Abudunia¹,

Kamal²,

Ziad³

et al. 2017

Nonsteroidal Anti-Inflammatory Drugs

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Calendula arvensis (CA) had been reported in traditional Moroccan medicine to exhibit its extensive use to treat pain and inlammation. Therefore, the objective of this study was to evaluate the anti-inlammatory activity of CA lowers. The methanol, aqueous, and hexane extracts (ME, AE, and HE) were investigated for inlammatory efects by using two methods, namely, carrageenan and experimental trauma-induced hind paw edema in rats and using indomethacin (20 mg/kg body weight) as a standard drug. The results demonstrated that Calendula Arvensis CA extracts had signiicant anti-inlammatory activity where the HE at the doses of 300 and 500 mg/kg p.o. (p < 0.001) had the best signiicant reduction and inhibition of edema with 51.08, 71.33 and 63.38, 67.33% induced by carrageenan and on experimental trauma induced rat paw edema at third hour, respectively, and similar as compared with standard drug indomethacin 20 mg/kg body weight p.o.(p < 0.001). These results indicate that it could be suggested as contributory efects to the use of CA lowers in the management of inlammation and pain conditions.

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Analgesic and Anti-inflammatory Activities ofBoswellia elongata balfMethanolic Extracts, as Endemic Plants in Yemen

Cited by 10 publications

References 25 publications

<p>Evaluation of Analgesic and Anti-Inflammatory Activities of 80% Methanol Root Extract of <em>Echinops kebericho</em> M. (Asteraceae)</p>

<p>Evaluation of Analgesic and Anti-Inflammatory Activities of 80% Methanol Root Extract of <em>Echinops kebericho</em> M. (Asteraceae)</p>

In VivoPotential Anti-Inflammatory Activity ofMelissa officinalisL. Essential Oil

In Vivo Potential Anti-Inflammatory Activity of Extracts from Calendula arvensis (CA) Flowers

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