Analgesic and anti-flammatory activities of the aqueous leaf extract of &lt;i&gt; Solanum nigrum&lt;/i&gt; Linn (solanaceae) in rats

Wannang, NN; Anuka, JA; Kwanashie, Helen O.; Auta, Asa

doi:10.4314/njpr.v5i1.53546

Cited by 29 publications

(26 citation statements)

References 3 publications

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“…Smooth muscle inhibition or relaxation by an agent synthetic or non synthetic are mediated by various mechanisms such as potassium channel opening or channel blockade, or by receptor antagonism such as antimuscarinic, antihistaminic, (12) or blockade of adrenoreceptors (13). Oxytocin produced a dose-dependent contraction on the uterus; the highest response produced by oxytocin at 0.8 I.U (1.144mg/ml) gives an Emax of 40.1±0.43.…”

Section: Discussionmentioning

confidence: 99%

Effect of <i>Solanum nigrun</i> on uterus of non-gravid rats

Agoreyo

Ohimai

Omigie

2017

Ethiop J Health Sci

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BACKGROUND: Solanum nigrum is a widely used plant in oriental medicine where it is considered to be antioxidant, antiinflammatory and diuretic. This study aimed to evaluate the effect of Solanum Nigrum on uterine contractions. METHOD: Female Wistar Wister albino rats were used for the study. They were housed in a single large cage in an atmospheric controlled environment. Twenty-four hours before every experiment, 0.2 mg/kg of diethylstilbesterol constituted in 1:1 ethanol/water solution, was administered intraperitoneally as a pre-treatment to the rats to induce oestrus. It was done for two weeks during the study period. The phytochemical analysis was carried out to test for the phytochemical constituent of the plant. RESULT: The result showed that the extract inhibited the release of intracellular calcium ion. The effect of acetylcholine was significantly inhibited by the extract that is at 200mg/ml (p>0.05) and 300 mg/ml (p<0.01). The highest mean inhibitory effect of the extract observed on acetylcholine induced contractions was 90.54 ± 1.15. The oxytocin induced contraction was significantly inhibited by the extract at 200 mg/ml (p<0.05) and at 300 mg/ml (p<0.001) doses respectively. The highest mean inhibitory effect of the extract observed on Oxytocin induced contractions was 41.10±1.02 and was significantly stronger compared with acetylcholine induced contractions. CONCLUSION: The aqueous extract of Solanum nigrun inhibited the activity of oxytocin on the uterus, and it may possess relaxant activity.

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Section: Discussionmentioning

confidence: 99%

Effect of <i>Solanum nigrun</i> on uterus of non-gravid rats

Agoreyo

Ohimai

Omigie

2017

Ethiop J Health Sci

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“…Solanum nigrum: Solanum nigrum is in traditional medical practice, to be useful in the treatment of epilepsy in some parts of Nigeria. The anti-seizure property of the extract was potentiated by amphetamine (Wannang et al, 2008).…”

Section: Prevalence Of Epilepsymentioning

confidence: 97%

Anticonvulsant potential of some medicinal plants and their beneficial properties

Asif¹

2013

TANG [HUMANITAS MEDICINE]

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Epilepsy has now become the most serious brain disorder. A number of synthetic antiepileptic drugs are available in practice, however their effectiveness does not grip true with the entire population suffering from epilepsy. Traditional systems of medicine are popular in developing countries and most of the population relies on traditional medicines for their primary health care need. Medicinal plants to be an important source of traditional medicines. Various plants are used for the treatment of epilepsy in traditional system of medicines and various plants are yet to be scientifically investigated. Phytoconstituents have been the basis of treatment of human diseases including epilepsy. Herbal products are extensively used for the treatment of many diseases worldwide and where allopathic fails or has severe side effects. Psycho neural drugs are also have very serious side effects like physical dependence, tolerance, deterioration of cognitive function and effect on respiratory, digestive and immune system. So the treatments through herbal medicines are widely used across the world due to their wide applicability and therapeutic efficacy with least side effects, which in turn has accelerated the research regarding natural therapy. In this review we have summarized some herbal antiepileptics.

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“…(Solanaceae), commonly known as “Black nightshade,” has been extensively used in traditional medicine in different parts of world to cure liver disorders, chronic skin ailments (Psoriasis and ringworm), inflammatory conditions, painful periods, fevers, diarrhea, eye diseases, hydrophobia, seizure, etc. [11–14] Also, the fruits are believed to have anti-tumor properties, although the mechanism for the activity remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of hydro-alcoholic extracts of Cucurbita pepo and Solanum nigrum on HepG2 and CT26 cancer cell lines

Shokrzadeh¹,

Azadbakht²,

Ahangar³

et al. 2010

Phcog Mag

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Plants are used worldwide for the treatment of diseases, and novel drugs continue to be developed through research from plants. There are more than 20,000 species of plants used in traditional medicines, and these are all potential reservoirs for new drugs. Cucurbita pepo has been used in traditional folk medicine to treat cold and alleviate ache. Previous pharmacological tests have shown that it possesses antiviral, anti-inflammatory, and analgesic effects. Also, Solanum nigrum has been used as a diuretic and an antipyretic agent and it has also been used to cure inflammation, edema, mastitis and hepatic cancer. In this investigation, cytotoxicity of specific concentrations of hydro-alcoholic extracts of C. pepo and S. nigrum was studied on normal [Chinese hamster ovarian cells (CHO) and rat fibroblast] and cancer (HepG2 and CT26) cell lines. The cytotoxic effects and IC50 of the extracts on the selected cell lines were studied followed by colonogenic assay method. The results showed that IC50 of S. nigrum extract was significantly lower than that of the C. pepo extract on all four cell lines (P < 0.05). On the other hand, IC50 of S. nigrum extract was significantly higher than the extract of Taxus baccata and Cisplatin, herbal and chemical control positive anticancer compounds, respectively, on all four cell lines (P < 0.05). As a result, it is concluded that the extract of S. nigrum has almost similar cytotoxicity to the extract of T. baccata on cancer cells.

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Analgesic and anti-flammatory activities of the aqueous leaf extract of <i> Solanum nigrum</i> Linn (solanaceae) in rats

Cited by 29 publications

References 3 publications

Effect of <i>Solanum nigrun</i> on uterus of non-gravid rats

Effect of <i>Solanum nigrun</i> on uterus of non-gravid rats

Anticonvulsant potential of some medicinal plants and their beneficial properties

Cytotoxicity of hydro-alcoholic extracts of Cucurbita pepo and Solanum nigrum on HepG2 and CT26 cancer cell lines

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