Analgesia with sevoflurane during labour: II. Sevoflurane compared with Entonox for labour analgesia

Yeo, S.T.; Holdcroft, Anita; Yentis, Steve; Stewart, Adrienne; Bassett, Paul

doi:10.1093/bja/ael327

Cited by 128 publications

(29 citation statements)

References 18 publications

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“…34 CSEA technique and low-dose epidural regimes: It combines the rapid, reliable onset of profound analgesia resulting from spinal injection with the flexibility and longer duration of epidural techniques.…”

Section: Recent Advancesmentioning

confidence: 99%

Labor Analgesia: An Unmet Right of Laboring Women in India

Sharma¹,

Menia²,

Bedi³

et al. 2013

Journal of South Asian Federation of Obstetrics and Gynaecology

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Labor pain has been described as one of the worst pain experienced by women in their lives. Medical science has made a continuous effort in this field to find a better method to alleviate the pain of labor. Since the historical use of ether for labor analgesia (1847) various pharmacological and nonpharmacological methods for labor analgesia have been evolved, each having its own merits and demerits. But even today the hunt by medical science continues to find an ideal method for labor analgesia (simple, cheap, effective, easily available, and free of side effects). To date neuroaxial/regional analgesia remains the gold standard method for labor analgesia. More than 5 decades have passed since the establishment of its effectiveness and safety profile but even today it is not available to most laboring women in India, and the concept of labor analgesia is like a fairy tale story to them. High patient load in hospitals, high cost of equipment and poor doctor/patient ratio are important obstacles for this. Thus, providing labor analgesia which is a right of every woman remains an unmet need.

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Section: Recent Advancesmentioning

confidence: 99%

Labor Analgesia: An Unmet Right of Laboring Women in India

Sharma¹,

Menia²,

Bedi³

et al. 2013

Journal of South Asian Federation of Obstetrics and Gynaecology

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“…1(2.0%), with p value of 0.617, showing insignificant difference statistically (Table 5). 8,16 These findings indicate that use of Tramadol as well as Entonox for labour analgesia does not increase the risk of adverse neonatal outcome. Both are safe for the neonates when use for labour analgesia.…”

Section: Discussionmentioning

confidence: 77%

“…8,17,19 The incidence of respiratory depression in the neonates was more in group I (Tramadol) i.e. 3(6.0%) in comparison to group II (Entonox) i.e.…”

Section: Discussionmentioning

confidence: 95%

“…8 They observed that the median (IQR [range]) pain relief scores were significantly higher for sevoflurane 67 (55-74 [33-100]) mm than for Entonox 51 (40-69.5 ) mm (P<0.037). They concluded that self-administered sevoflurane at subanaesthetic concentration (0.8%) can provide useful pain relief during the first stage of labour, and to a greater extent than Entonox…”

Section: Discussionmentioning

confidence: 99%

“…This indicates that Entonox causes more nausea and vomiting when compared with Tramadol for labour analgesia. 8,6 The incidence of overall post natal complications [urinary retention (1) The overall satisfaction level of the parturients in group II (Entonox) at 1 hr post delivery was 5.06±1.42 and 24 hr post delivery was 6.64±1.66 which was more when compared with tramadol group. The difference was statistically significant (p value was <0.001).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of effectiveness of intermittent inhalational entonox in comparison with opioid tramadol for labour analgesia

Kumar¹,

Chandel

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONGiving birth is a painful process. Any intervention that leads to improvement in pain relief is worthy of investigation 1 . Opioid as well as epidural analgesia is effective means for pain relief in labour, notwithstanding their shortcomings. Data regarding Entonox (50% Nitrous Oxide and 50% Oxygen mixture) for labour analgesia is not available in current Indian literature. Use of Entonox offers many apparent advantages over the ABSTRACT Background:Childbirth is an emotion-filled event and the mother needs to bond with her newborn baby as early as possible. Any intervention that leads to improvement in pain relief is worthy of investigation. Entonox, opioids as well as epidural analgesia are effective means for pain relief in labour, notwithstanding their shortcomings. The objectives of study are to compare the effectiveness of intermittent inhalational Entonox for labour analgesia with intramuscular opioid (Tramadol) and to compare the effects of Entonox and Tramadol as labour analgesia on the maternal and fetal outcome of labour. Methods:The study was a prospective randomized, comparative study of two established techniques of labour analgesia. The study was carried out in 100 subjects. These subjects are divided into two groups. Group A -Tramadol Group: 50 women in active labour who received 100 mg tramadol intramuscularly with repeat dose of 50mg tramadol 4 hourly. Group B -Entonox Group: 50 women in active labour who received entonox for labour analgesia. Results:The mean VAS (visual analogue score) i.e. the pain score in group I (Tramadol) was 4.58±1.54 and Group II (Entonox) was 4.02±1.99 which is significantly low when compared to Group I (Tramadol) p<0.001. Study also showed that both the analgesics Entonox as well as Tramadol does not cause any significant change when compared for duration of labor. The rate of instrumental assisted vaginal deliveries and normal vaginal deliveries were almost equal in both the groups. In our study, the mean overall satisfaction level of the parturients in group II (Entonox) at 1 hr post delivery was (5.06±1.42) and 24 hr post delivery was (6.64±1.66) which was more when compared with tramadol group. The difference was statistically significant (p value was <0.001). This indicates that overall satisfaction level of the parturients is more with the use of Entonox when compared with Tramadol. Conclusions: Therefore, it is concluded that intermittent inhalational Entonox provides better labour analgesia then intramuscular opioid Tramadol.

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