Anal squamous intraepithelial lesions: an update and proposed management algorithm

Chittleborough, Timothy; Tapper, Richard; Eglinton, Timothy; Frizelle, Frank

doi:10.1007/s10151-019-02133-4

Cited by 13 publications

(7 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients with an intraepithelial lesion may present with bleeding or anal lesion symptoms, but the vast majority of patients are asymptomatic [215,216]. However, invasive carcinoma often presents with bleeding, tenesmus, and a palpable mass on clinical examination [206].…”

Section: Hpv and Anal Cancermentioning

confidence: 99%

“…Anal cancer screening is not a consensus among international societies [216]. Intraepithelial lesions are rare in the general population, which would not justify a universal screening program; however, screening for precancerous lesions in the higher-risk population should be considered, e.g., for HIV-positive, MSM, and immunocompromised patients, and women with a history of dysplasia or invasive cervical carcinoma [216][217][218][219][220].…”

Section: Hpv and Anal Cancermentioning

confidence: 99%

See 1 more Smart Citation

Proteases and HPV-Induced Carcinogenesis

Vieira

Santos

Lepique

et al. 2022

Cancers

View full text Add to dashboard Cite

Persistent infection with Human papillomavirus (HPV) is the main etiologic factor for pre-malignant and malignant cervical lesions. Moreover, HPV is also associated with oropharynx and other anogenital carcinomas. Cancer-causing HPV viruses classified as group 1 carcinogens include 12 HPV types, with HPV 16 and 18 being the most prevalent. High-risk HPVs express two oncoproteins, E6 and E7, the products of which are responsible for the inhibition of p53 and pRB proteins, respectively, in human keratinocytes and cellular immortalization. p53 and pRB are pleiotropic proteins that regulate the activity of several signaling pathways and gene expression. Among the important factors that are augmented in HPV-mediated carcinogenesis, proteases not only control processes involved in cellular carcinogenesis but also control the microenvironment. For instance, genetic polymorphisms of matrix metalloproteinase 1 (MMP-1) are associated with carcinoma invasiveness. Similarly, the serine protease inhibitors hepatocyte growth factor activator inhibitor-1 (HAI-1) and -2 (HAI-2) have been identified as prognostic markers for HPV-dependent cervical carcinomas. This review highlights the most crucial mechanisms involved in HPV-dependent carcinogenesis, and includes a section on the proteolytic cascades that are important for the progression of this disease and their impact on patient health, treatment, and survival.

show abstract

Section: Hpv and Anal Cancermentioning

confidence: 99%

Section: Hpv and Anal Cancermentioning

confidence: 99%

Proteases and HPV-Induced Carcinogenesis

Vieira

Santos

Lepique

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…La fisiopatología de ASIL comparte similitudes con otras neoplasias intraepiteliales anogenitales y suele ser desencadenada por la infección por el virus del papiloma humano (VPH). Es importante destacar que una ASIL de alto grado, si no se trata adecuadamente, tiene una probabilidad de progresar a cáncer invasivo de aproximadamente el 9% en los próximos cinco años, aunque este riesgo puede reducirse significativamente, hasta un 3%, con un tratamiento oportuno 3 .…”

Section: Introductionunclassified

La importancia de la anoscopia de alta resolución para la detección temprana de lesiones intraepiteliales escamosas anales de alto riesgo en pacientes con enfermedad inflamatoria intestinal y tratamiento inmunosupresor

Sánchez-Rosado,

Aceves-Valdez,

Vela-Torres

et al. 2024

CIRCOL

View full text Add to dashboard Cite

La lesión intraepitelial escamosa anal (ASIL) es una condición premaligna que precede al carcinoma de células escamosas (SCC) en el ano. La infección por el virus del papiloma humano (VPH) se considera un factor de riesgo importante en su desarrollo, y la detección temprana mediante anoscopia de alta resolución (HRA) puede ser crucial para prevenir su progresión. La detección precoz de lesiones premalignas como ASIL en pacientes con enfermedad inflamatoria intestinal bajo terapia inmunosupresora es un área de investigación importante y poco estudiada. Presentamos el caso de un hombre de 29 años con colitis ulcerosa crónica idiopática que recibía tratamiento con anti-factor de necrosis tumoral y ácido 5-aminosalicílico. Durante su seguimiento médico, se identificó una úlcera anal crónica que requirió dos intervenciones quirúrgicas en 2021 y 2022, con hallazgos histopatológicos que confirmaron la presencia de ASIL de bajo grado. En enero de 2023 se sometió a una HRA que reveló la presencia de células escamosas atípicas de significado indeterminado, lo que llevó a la realización de una electrofulguración de las lesiones sospechosas de infección por VPH. Aunque la prevalencia exacta de ASIL/SCC en este grupo de pacientes aún no se conoce, la HRA desempeña un papel relevante en su identificación oportuna. Se necesitan estudios adicionales para comprender mejor cómo la terapia inmunosupresora puede influir en la progresión de estas lesiones y para establecer pautas precisas de detección y manejo.

show abstract

“…Anal squamous cell cancer (ASCC) is a type of relatively rare malignant tumour of the digestive tract, but its incidence and mortality rate have increased annually in the USA by 2.7% and 3.1%, respectively 1. ASCC is considered the most common pathological type of anal cancer and anal intraepithelial neoplasm (AIN) is deemed to be the precancerous lesion for ASCC 2. Unlike cervical cancer, which has a well-established screening system and is prevalent among sexually active women, the screening for ASCC and AIN lacks a widely approved process and is advised to be used only for high-risk population 3.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the quality and reliability of anal cancer and its precancerous lesions-related content on YouTube: a cross-sectional study

Chen,

Pan,

Zhou

et al. 2023

BMJ Open

View full text Add to dashboard Cite

ObjectivesThis research aims at evaluating the quality of anal cancer and its precancerous lesions-related videos on YouTube.DesignCross-sectional survey design.SettingUSA.ParticipantsThe top 150 videos on YouTube were selected for analysis based on three search terms. The duplicate, irrelevant, commercial, operation-related and audio-free videos were excluded. Finally, 105 relevant videos were included.MethodsWe assessed the completeness of video content from six dimensions and marked the men having sex with men (MSM)-related videos. To measure the video quality, DISCERN,Journal of the American Medical Association(JAMA) Benchmark Criteria, Patient Education Materials Assessment Tool (PEMAT) and Global Quality Scale (GQS) were used. The correlation between DISCERN classification and duration,JAMA, PEMAT and GQS scores were recorded.ResultsThe video content was mainly about the management of the disease (mean score 1.086). Overall, the quality of videos uploaded by the non-profit organisation was relatively high. A correlation existed between each other of theJAMA, DISCERN and GQS scores (p<0.001). Moreover, they were positively correlated with video duration and PEMAT scores (p<0.001).ConclusionsAlthough the overall quality of information about anal cancer and its precancerous lesions videos on YouTube is acceptable, it might not fully meet the health information needs of patients. Therefore, they should exercise caution when using YouTube as a source of anal cancer-related information, especially the MSM population.

show abstract

Anal squamous intraepithelial lesions: an update and proposed management algorithm

Cited by 13 publications

References 52 publications

Proteases and HPV-Induced Carcinogenesis

Proteases and HPV-Induced Carcinogenesis

La importancia de la anoscopia de alta resolución para la detección temprana de lesiones intraepiteliales escamosas anales de alto riesgo en pacientes con enfermedad inflamatoria intestinal y tratamiento inmunosupresor

Evaluation of the quality and reliability of anal cancer and its precancerous lesions-related content on YouTube: a cross-sectional study

Contact Info

Product

Resources

About