Anal HPV 16 and 18 viral load: A comparison between HIV‐negative and ‐positive MSM and association with persistence

Marra, Elske; King, Audrey J.; Logchem, Elske van; Weele, Pascal van der; Mooij, Sofie H.; Heijman, Titia; Meijer, Chris J.L.M.; Verhagen, Dominique W M; Sande, Marianne A. B. van der; Loeff, Maarten F. Schim van der

doi:10.1002/jmv.24898

Cited by 6 publications

(10 citation statements)

References 38 publications

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“…is study results confirmed data obtained from similar observations on the MSM population from Holland [25] and Russia [11]-HIV infection correlates with HPV infection.…”

Section: Discussionsupporting

confidence: 90%

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The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia

Beliakov¹,

Senina²,

Tyulenev³

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Objective. Men who have sex with men (MSM) have a high risk of lifelong anal cancer caused by high-risk human papillomavirus (HR HPV) infections. The aim of this study was to investigate the prevalence of anal canal HR HPV infection among men who have sex with men (MSM) with and without HIV infection in Moscow (Russia). We evaluated associations of some HIV coinfections (HSV and CMV) and HPV distribution among MSM with and without HIV infection. Methods. Two groups of HIV-positive (n = 60) and HIV-negative (n = 60) MSM were evaluated in the study. Fourteen high-risk (HR) HPV types, HSV1/2, and CMV were investigated in men anal swabs. Results. HR HPVs were found with nearly the same frequency of 66.7% in both groups: HIV-positive and HIV-negative MSM. HIV-positive status was statistically associated with the presence of several (more than two) HPV types ( p = 0.044 ). The most prevalent HR HPV genotypes were HPV18, HPV16, HPV56, and HPV33 for HIV-positive MSM and HPV56, HPV51, HPV66, and HPV16 for HIV-negatives. We found a statistically significant association of five HR HPV types with HIV status of MSM: HPV16 ( p = 0.028 ), HPV18 ( p = 0.00006 ), HPV58 ( p = 0.003 ), HPV33 ( p = 0.019 ), and HPV39 ( p = 0.026 ). The frequency of HSV1 (1.7%) and HSV2 (10%) infections and CMV (3.3%) infection was evaluated in the group of HIV-positive MSM. The frequency of HSV1 (5%) and HSV2 (6.7%) infections and CMV (0%) infection was evaluated, as well, in the group of HIV-negative MSM. Conclusion. Multiple HPV genotypes were detected significantly more often than single HPV genotype in the group of HIV-positive MSM. According to our data, 25% of HIV-positive MSM have HPV39; this is the only one of the five types of HR HPV (16, 18, 58, 33, and 39) associated with this group of MSM that has not yet been included in the HPV vaccines available on the market.

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“…is study results confirmed data obtained from similar observations on the MSM population from Holland [25] and Russia [11]-HIV infection correlates with HPV infection.…”

Section: Discussionsupporting

confidence: 90%

“…On the other side, the HIV-positive MSM tended to have more sexual partners and more sex episodes per lifetime than HIV-negative MSM [25]. We observed nearly equal sexual activity with both criteria: "a number of anal sex partners in the last 6 months" and "a number of lifetime male sex partners" in HIV-positive and HIV-negative groups.…”

Section: Discussionmentioning

confidence: 53%

The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia

Beliakov¹,

Senina²,

Tyulenev³

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…Moreover, we found that the most prevalent genotype was HPV-53 (27%), followed by HPV-16 and 6 (23% and 22%, respectively) rather than HPV-51 found in the French cohort 13 ; in fact, HPV-16 prevalence was found to be significantly higher in MSM than in men who have sex with women and in PLWH compared with HIV-negative subjects, suggesting that sexual behavior and HIV infection are independent strong determinants of male anal HPV-16 infection. 14 The high prevalence for HPV-16 in our cohort and other cohorts up to 29% in the APACHES study 15 has important consequences on clinical management because it is the most carcinogenic serotype. 16 Surprisingly, the proportion of anal cancer attributable to HPV-16 is smaller in PLWH than in the seronegative population, while all the other serotypes are more represented.…”

Section: Discussionmentioning

confidence: 73%

Prevalence and Risk Factors of Anal HPV Infection in MSM Living With HIV: Identifying the Target Groups to Prioritize for Immunization

Bruzzesi

Galli

Poli

et al. 2022

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…through reduction of viral load during coinfection [13,14,15]. Although competition for transmissibility is not captured by the proposed predictors, it is likely correlated with competition in clearance, as HPV persistence is also determined by viral load [16]. Hence, the predictors may retain good predictive ability even when not all mechanisms of interactions are captured.…”

Section: Discussionmentioning

confidence: 99%

“…HPV types may compete during coinfection, by either diminishing each other's opportunities to establish a productive infection or by promoting viral clearance (e.g. through activation of antigen-presenting cells) [13,14,15,16,17]. Due to such competitive mechanisms, the hazard of acquiring (or clearing) a given HPV type may be reduced (or increased, respectively) by infection with other types.…”

Section: Introductionmentioning

confidence: 99%

Capturing multiple-type interactions into practical predictors of type replacement following HPV vaccination

Man

Auranen

Wallinga

et al. 2019

Preprint

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Current HPV vaccines target a subset of the oncogenic human papillomavirus (HPV) types. If HPV types compete during infection, vaccination may trigger replacement by the non-targeted types. Existing approaches to assess the risk of type replacement have focussed on detecting competitive interactions between pairs of vaccine and non-vaccine types. However, methods to translate any inferred pairwise interactions into predictors of replacement have been lacking. In this paper, we develop practical predictors of type replacement in a multi-type setting, readily estimable from pre-vaccination longitudinal or cross-sectional prevalence data. The predictors we propose for replacement by individual non-targeted types take the form of weighted cross hazard ratios of acquisition versus clearance, or aggregate odds ratios of coinfection with the vaccine types. We elucidate how the hazard-based predictors incorporate potentially heterogeneous direct and indirect type interactions by appropriately weighting type-specic hazards and show when they are equivalent to the odds-based predictors. Additionally, pooling type-specic predictors proves to be useful for predicting increase in the overall non-vaccine-type prevalence.Using simulations, we demonstrate good performance of the predictors under dierent interaction structures. We discuss potential applications and limitations of the proposed methodology in predicting type replacement, as compared to existing approaches.

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Anal HPV 16 and 18 viral load: A comparison between HIV‐negative and ‐positive MSM and association with persistence

Cited by 6 publications

References 38 publications

The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia

The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia

Prevalence and Risk Factors of Anal HPV Infection in MSM Living With HIV: Identifying the Target Groups to Prioritize for Immunization

Capturing multiple-type interactions into practical predictors of type replacement following HPV vaccination

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