Anal Carcinoma

Engstrom, Paul F.; Arnoletti, J. Pablo; Benson, Al B.; Berlin, Jordan; Berry, J. Michael; Chen, Yi Jen; Choti, Michael A.; Cooper, Harry S.; Dilawari, Raza A.; Early, Dayna S.; Enzinger, Peter C.; Fakih, Marwan; Fleshman, James; Fuchs, Charles; Grem, Jean L.; Knol, James A.; Leong, Lucille; Lin, Edward; Mulcahy, Mary F.; Rohren, Eric M.; Ryan, David P.; Saltz, Leonard; Shibata, David; Skibber, John M.; Small, William; Sofocleous, Constantinos T.; Thomas, J. Regan; Venook, Alan P.; Willett, Christopher G.

doi:10.6004/jnccn.2010.0007

Cited by 57 publications

(15 citation statements)

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“…Lymphatic drainage in anal tumors is dependent on the location of the tumor in the anal region 20. Lymph drainage at and proximal to the dentate line is directed toward the anorectal, perirectal, and paravertebral nodes and to some of the internal iliac system nodes 9. Lymph drain of the lower anal canal and external anal sphincter is via the perianal plexuses into vessels then the external inguinal lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

“…Lymph drain of the lower anal canal and external anal sphincter is via the perianal plexuses into vessels then the external inguinal lymph nodes. Cancers in the perianal skin and the anal canal distal to the dentate line drain mainly to the superficial inguinal nodes 9. However, considering this marked variation in the lymphatic drainage and the numerous connections between lymphatics at various levels of the anal canal 22, distal anal cancers present with a higher incidence of inguinal node metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…The recommended first-line treatment for patients with stage II/III anal carcinoma is concurrent chemoradiotherapy with mitomycin-C and 5-fluorouracil (5-Fu) 5-8. While initially, the radiation fields did include the inguinal nodes and the pelvis, anus, and perineum 9, 10, the need for inclusion of inguinal nodes in the radiation fields is still inconclusive. Several randomized trials have shown that elective irradiation of the groin should be considered for all tumors to reduce inguinal progression risk 6, 11-13.…”

Section: Introductionmentioning

confidence: 99%

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Anal adenocarcinoma requires prophylactic inguinal nodal treatment: Results from a single Chinese institution

Guo

Mao

et al. 2017

J. Cancer

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Background: Literature pertaining to prophylactic inguinal nodal treatment for anal adenocarcinoma in China is scarce.Methods: In this retrospective study, we analyzed 126 patients from 1965 to 2015. Among these, 67 patients received surgery only, 18 patients received chemoradiotherapy only, 27 patients received a combination of both, and the remaining 14 patients received palliative treatment.Results: The median follow up period was 30 months. The 1-year, 3-year, and 5-year overall survival rates were 85.8%, 62.5%, and 43.4%, respectively. The 5-year overall survival was 46.9% for patients with negative inguinal lymph nodes and 19.1% for patients with positive inguinal lymph nodes (p=0.007). The overall 5-year inguinal node relapse-free survival was 83.0%. The 5-year inguinal node relapse-free survival was 87.5% for stage I, 86.9% for stage II, and 76.5% for stage III cancers. Among those with negative inguinal nodes, the 5-year inguinal node relapse-free survival was 85.7% for negative regional lymph nodes and 75.4% for positive regional lymph nodes (p=0.089).Conclusion: Inguinal lymph node is a high-risk subclinical area. Prophylactic inguinal nodal treatment is necessary for patients with anal adenocarcinoma irrespective of positive or negative inguinal lymph nodes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anal adenocarcinoma requires prophylactic inguinal nodal treatment: Results from a single Chinese institution

Guo

Mao

et al. 2017

J. Cancer

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“…Conversely, prostate cancer incidence is more than 100 times higher and accounts for approximately 27.6% of all malignancies in men [1]. Established treatment guidelines for localized anal cancer involve radiotherapy to the primary site and draining lymphatics to include the pelvic and inguinal nodes [2] as well as the use of concurrent systemic chemotherapy [3]. The use of pelvic radiotherapy is also well established for the treatment of localized prostate cancer, with or without concurrent hormonal therapy [4].…”

Section: Introductionmentioning

confidence: 99%

Metachronous Anal Canal and Prostate Cancers with Simultaneous Definitive Therapy: A Case Report and Review of the Literature

Miles

Jacimore

Nelson

2011

Case Reports in Oncological Medicine

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Anal canal cancer is rare, accounting for only 1.3% of all gastrointestinal tract malignancies. Prostate cancer incidence is much higher and accounts for 27.6% of all malignancies in men. Treatment guidelines for anal cancer involve radiotherapy to the primary site and draining lymphatics while treatment for prostate cancer can also include pelvic radiotherapy. The literature is silent on the optimum course of action when these two malignancies are found synchronously or metachronously. Herein, we report a case of a patient diagnosed with intermediate risk prostate cancer who, prior to definitive therapy for this first malignancy, was also diagnosed with anal canal cancer. We conclude that a simultaneous approach with radiation therapy and chemotherapy with subsequent boost to the prostate is recommended. Screening for synchronous prostate cancer in male anal canal cancer patients is probably indicated and may preclude suboptimal treatment for a second occult primary.

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“…Anogenital preinvasive and invasive lesions are known to have been on the increase in the industrialised world since the 1970s 1. The increase in anal squamous cell carcinomas and Kaposi's sarcomas (KS) has often been associated with the HIV epidemic, especially among men having sex with men.…”

mentioning

confidence: 99%

Anogenital preinvasive and invasive lesions in the Limpopo Province of South Africa

Bogaert

2015

Sex Transm Infect

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Anal Carcinoma

Cited by 57 publications

References 0 publications

Anal adenocarcinoma requires prophylactic inguinal nodal treatment: Results from a single Chinese institution

Anal adenocarcinoma requires prophylactic inguinal nodal treatment: Results from a single Chinese institution

Metachronous Anal Canal and Prostate Cancers with Simultaneous Definitive Therapy: A Case Report and Review of the Literature

Anogenital preinvasive and invasive lesions in the Limpopo Province of South Africa

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