“…The "war against pain" launched two decades ago in the US has been described as similar to opening Pandora's box, particularly by allowing nonanesthesiologists to administer potent anesthetics [45]. Clearly, this war has been lost by many patients: it is estimated to have caused 10,000 to 20,000 drug-overdose deaths in the US (and the many other adverse effects of long-term opioids also need to be considered [46,47]).…”