Anaesthesia and the QT interval in humans: effects of halothane and isoflurane in premedicated children

Michaloudis, D.; Fraidakis, O.; Lefaki, T.; Kanakoudis, F.; Askitopoulou, H.

doi:10.1097/00003643-199811000-00001

Cited by 38 publications

(26 citation statements)

References 29 publications

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“…The hemodynamic parameters were maintained throughout the perioperative period. There was a minimal reduction in the heart rate and blood pressure which was comparable with studies done by Hoch et [12][13][14][15][16][17][18][19][20][21][22][23][24] Only 2 patients developed ventricular ectopics, which disappeared after discontinuation of Halothane without treatment. [25][26][27] The recovery from anesthesia was smooth and fast.…”

Section: Spo2supporting

confidence: 86%

Fen T a Nyl Oxygen - Nitrous Oxide Halothane for Puerperal Sterilisation

Jeyanthan¹,

Balamurugan²,

Pitchchaiaya³

et al. 2015

jemds

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BACKGROUND:Puerperal Sterilization is one of the terminal contraceptive methods accounting for about 85% of all sterilizations in India. Various options are available to provide anaesthesia for puerperal sterilisation under laparoscopy. This study was aimed to evaluate the efficacy of fentanyl -Oxygen-Nitrous oxide-Halothane sequence in providing adequate intraoperative anesthesia with less awareness, rapid recovery and extended postoperative analgesia. METHODS: Forty female patients of 20-40 years age group for puerperal sterilization were included in this study. With standard monitoring care, all patients were induced with fentanyl 2 mcg/kg, Oxygen-Nitrous oxide in the ratio of 50:50 with Halothane 0.5%. Halothane concentration was increased to 1% after 1 minute, 2% until the peritoneum was opened and maintained at 1% till the end of the surgery. RESULTS: Mean procedure duration was 20-30 minutes. Eye opening was observed within one minute in 3 patients, within 2 minutes in 29 patients and within 3 minutes in 8 patients. Verbal command response was in 2 minutes for 3 patients, 3 minutes in 29 patients and 8 patients in 4 minutes. Heart rate fluctuation was significant during the first 5 minutes (+/-7.095) of surgical procedure. Fluctuation in systolic blood pressure was only 10-15% which lasted for few minutes in all these patients. There was no significant change in diastolic pressure and arterial oxygen saturation. Though two patients developed ventricular ectopics, it was subsided immediately after discontinuation of Halothane. CONCLUSION: Short acting fentanyl can be used safely with oxygen-nitrous oxide-halothane combination for short procedures like puerperal sterilization. This technique is safe as well as cost effective.

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Section: Spo2supporting

confidence: 86%

Fen T a Nyl Oxygen - Nitrous Oxide Halothane for Puerperal Sterilisation

Jeyanthan¹,

Balamurugan²,

Pitchchaiaya³

et al. 2015

jemds

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“…Sevoflurane, isoflurane, and thiopental have been reported to prolong QTc, but the clinical significance of this finding has been unclear. [22][23][24] Recent studies, which have suggested that sevoflurane significantly prolonged the preoperative QTc, were not able to find such a relationship for propofol. On the other hand, neither sevoflurane nor propofol was found to exaggerate physiologic QTD and QTcD.…”

Section: Discussionmentioning

confidence: 96%

Laparoscopic Surgery: Does It Increase the Probability of Atrial and Ventricular Arrhythmias in Children?

Çiftçi

Elemen

et al. 2008

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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“…Autonomic nerve system changes developing especially during general anesthesia cause changes in the QT interval 10 . Fear before surgery, agents used for anesthetic induction, laryngoscopy and endotracheal intubation procedures or developing hemodynamic and neuroendocrine responses have been researched to explain rhythm disorders observed on electrocardiography 11,12 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia

et al. 2014

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PURPOSE:To compare the effects of sugammadex and neostigmine, used to antagonize the effects of rocuronium, on the QT c interval. METHODS:This study used 10 adult New Zealand white rabbits of 2.5-3.5 kg randomly divided into two groups: sugammadex group (Group S, n:5) and neostigmine group (Group N, n:5). For general anesthesia administering 2 mg/kg iv propofol and 1 mcg/ kg iv fentanyl, 0.6 mg/kg iv rocuronium was given. Later to provide reliable airway for all experimental animals V-Gel Rabbit was inserted. The rabbits were manually ventilated by the same anesthetist. After the V-Gel Rabbit was inserted at 2,5,10,20, 25, 27, 30 and 40 minutes measurements were repeated and recorded. At 25 minutes after induction Group N rabbits were given 0.05 mg/kg iv neostigmine + 0.01 mg/kg iv atropine. Group S were administered 2 mg/kg iv sugammadex. RESULTS:Comparing the QT c interval in the rabbits in Group S and Group N, in the 25th, 27th and 30th minute after muscle relaxant antagonist was administered the QT c interval in the neostigmine group rabbits was significantly increased (p<0.05). CONCLUSION:While sugammadex, administered to antagonize the effect of rocuronium, did not significantly affect the QT c interval, neostigmine+atropine proloned the QT c interval.

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Anaesthesia and the QT interval in humans: effects of halothane and isoflurane in premedicated children

Cited by 38 publications

References 29 publications

Fen T a Nyl Oxygen - Nitrous Oxide Halothane for Puerperal Sterilisation

Fen T a Nyl Oxygen - Nitrous Oxide Halothane for Puerperal Sterilisation

Laparoscopic Surgery: Does It Increase the Probability of Atrial and Ventricular Arrhythmias in Children?

Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia

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