Anaesthesia after neoadjuvant chemotherapy, immunotherapy or radiotherapy

Groenewold, M.D.; Olthof, C. G.; Bosch, Dirk

doi:10.1016/j.bjae.2021.08.002

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…Some studies have also investigated the effect of combining several of these strategies before the surgical resection of a tumor, in some cases with significant improvement in treatment [ 11 , 12 , 13 ]. Unfortunately, alone or in combination, these treatment modalities target rapidly dividing cancerous cells and non-malignant cells and thereby induce toxicity [ 14 ]. Although chemotherapy is a standard cancer treatment, it has additional disadvantages, such as poor bioavailability of some anti-cancer drugs, and susceptibility to multi-drug resistance, leading to unsatisfactory therapeutic effects [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Amaryllidaceae Plants against Cancer Cells: Biotechnological, In Vitro, and In Silico Approaches

et al. 2023

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Cancer is a major cause of death and an impediment to increasing life expectancy worldwide. With the aim of finding new molecules for chemotherapeutic treatment of epidemiological relevance, ten alkaloid fractions from Amaryllidaceae species were tested against six cancer cell lines (AGS, BT-549, HEC-1B, MCF-7, MDA-MB 231, and PC3) with HaCat as a control cell line. Some species determined as critically endangered with minimal availability were propagated using in vitro plant tissue culture techniques. Molecular docking studies were carried out to illustrate binding orientations of the 30 Amaryllidaceae alkaloids identified in the active site of some molecular targets involved with anti-cancer activity for potential anti-cancer drugs. In gastric cancer cell line AGS, the best results (lower cell viability percentages) were obtained for Crinum jagus (48.06 ± 3.35%) and Eucharis bonplandii (45.79 ± 3.05%) at 30 µg/mL. The research focused on evaluating the identified alkaloids on the Bcl-2 protein family (Mcl-1 and Bcl-xL) and HK2, where the in vitro, in silico and statistical results suggest that powelline and buphanidrine alkaloids could present cytotoxic activity. Finally, combining experimental and theoretical assays allowed us to identify and characterize potentially useful alkaloids for cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Amaryllidaceae Plants against Cancer Cells: Biotechnological, In Vitro, and In Silico Approaches

et al. 2023

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“…There are specific concerns regarding different chemotherapeutic agents, which are extensively discussed elsewhere. 3 The anesthetic implications of the different immunomodulatory agents and radiotherapy are described in Table 1 . Depending on the stem cell donor and recipient's blood group, HSCT can lead to major, minor, or bidirectional ABO incompatibility.…”

Section: Tablementioning

confidence: 99%

Perioperative Management of a Recipient of Allogenic Hematopoietic Stem Cell Transplant Undergoing Neurosurgery

Nandwana,

Sokhal,

Chowdhury

et al. 2024

J Neuroanaesth Crit Care

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“… 20 The main route to elimination of PPC is the excretion of the unchanged molecule in urine. 21 , 22 However, studies on pigs show that the liver plays a more important role than the kidney in the plasma clearance of PPC. 23 That may suggest similar results in humans.…”

Section: Muscle Relaxant’s Characteristics and Usage After Chemothera...mentioning

confidence: 99%

The Use of Muscle Relaxants After Chemotherapy and Radiotherapy

Radkowski,

Jacewicz,

Podlińska

et al. 2024

IJGM

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Introduction Patients after chemotherapy and radiotherapy while being operated can suffer from different systemic problems, which may complicate the anesthetic management. Some interactions between muscle relaxants and chemotherapeutics can occur. Aim This article aims to present the use of muscle relaxants in cancer patients who have undergone chemotherapy and radiotherapy. Material and Methods Our work is based on the available literature and the authors’ experience. Conclusion Based on our observations and a thorough examination of the medical literature, it is advisable to exercise significant caution when employing muscle relaxants in individuals undergoing chemotherapy and radiotherapy. All muscle relaxants can behave differently after chemotherapy and radiotherapy, and for this reason, practitioners should familiarize themselves with the pharmacodynamics and pharmacokinetics of their chosen muscle relaxant.

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Anaesthesia after neoadjuvant chemotherapy, immunotherapy or radiotherapy

Cited by 8 publications

References 24 publications

Cytotoxic Activity of Amaryllidaceae Plants against Cancer Cells: Biotechnological, In Vitro, and In Silico Approaches

Cytotoxic Activity of Amaryllidaceae Plants against Cancer Cells: Biotechnological, In Vitro, and In Silico Approaches

Perioperative Management of a Recipient of Allogenic Hematopoietic Stem Cell Transplant Undergoing Neurosurgery

The Use of Muscle Relaxants After Chemotherapy and Radiotherapy

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