The microalgae Chlorella sorokiniana was used as co-substrate for waste activated sludge (WAS) anaerobic digestion in order to increase process stability, biodegradability and methane yield. Different co-digestion mixtures (0% WAS-100% microalgae; 25% WAS-75% microalgae; 50% WAS-50% microalgae; 75% WAS-25% microalgae; 100% WAS-0% microalgae) were studied. The highest methane yield (442 mL CH4/g VS) was obtained for the mixture 75% WAS-25% microalgae. This value was 22% and 39% higher than that obtained in the anaerobic digestion of the alone substrates WAS and microalgae, respectively, as well as 16% and 25% higher than those obtained for the co-digestion mixtures 25% WAS-75% microalgae and 50% WAS-50% microalgae, respectively. The kinetic constant of the process increased 42%, 42% and 12% for the mixtures with 25%, 50% and 75% of WAS compared to the substrate without WAS. Anaerobic digestion of WAS, together with Chlorella, has been clearly improved by ensuring its viability, suitability and efficiency.