Anaerobic Bacterial Endocarditis

Felner, Joel M.; Dowell, V. R.

doi:10.1056/nejm197011262832203

Cited by 164 publications

(57 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…are reported in the literature (18). P. acnes is one of the anaerobic bacteria that can cause endocarditis (19,20). Accordingly, the bacteria listed above should not automatically be rejected as contaminants, at least not when major precautions are taken to prevent contamination, as in the present study.…”

Section: Discussionmentioning

confidence: 70%

Multiple Bacteria in Calcific Aortic Valve Stenosis

Kolltveit

Geiran

Tronstad³

et al. 2002

Microbial Ecology in Health and Disease

View full text Add to dashboard Cite

Calci c aortic valve stenosis affects an increasin g number of elderly patients and causes considerable morbidity. The etiology of this disease is unclear . Lately, the issue has been raised that its pathogenesis may be linked to chronic in ammation caused by microorganisms. The aim of the present study was to investigat e if bacteria are present in calci c stenotic aortic valves. Tissue specimen s were collected from 19 patients undergoin g aortic valve replacemen t for aortic valve stenosis and from ten patients with regurgitant aortic valves or clinically healthy valves from explanted hearts (controls). Specimen s were sectioned and subjected to transmission and scanning electron microscopy, as well as to anaerobic culturing. Bacteria of various morphologies (cocci, rods, spiral and crescent forms) were detected in 16 of the 19 patients with valve stenosis. Twelve of these patients yielded positive cultures and 12 were positive assessed by electron microscopy. The bacteria were present in brous tissue in the thickened areas of the valve and in lacuna e of calci ed nodules. Bacteria seemingly undergoin g cell division were observed . M acrophage digestio n of bacteria was also noticed. No bacteria were detected in the valves from the control group except in one patient. Bacteria of different morphologies were observed in calci c stenotic aortic valves. It appear s likely that the bacteria are implicated in the pathogenesis of acquired, calci c aortic valve stenosis.

show abstract

Section: Discussionmentioning

confidence: 70%

Multiple Bacteria in Calcific Aortic Valve Stenosis

Kolltveit

Geiran

Tronstad³

et al. 2002

Microbial Ecology in Health and Disease

View full text Add to dashboard Cite

show abstract

“…Tüm endokarditlerin yaklaşık %2-16'sını oluş-turan anaerobik kapak endokarditi, mortalitesi yüksek olan bir endokardit tipidir (1,2) . Anaerobik doğal kağak endokarditi sıklığı literatürde düşük olarak bildirilmişse de, hastanın komorbit hastalık-ları, kardiyak cerrahi sıklığının artışı, geniş spektrumlu antibiyotiklerin gelişigüzel kullanımı, hastane içi parenteral beslenmenin sık kullanılır hâle gelmesi gibi nedenlerle ve immün sistemi baskı-lanmış hasta sayılarındaki artış sonucu giderek yükselmektedir (3) .…”

Section: Discussionunclassified

“…Anaerobik bakteriler infektif endokardit etkeni olarak düşük oranda görülmesine (%2-16) karşın, önem-li bir klinik yere sahiptir. En sık görülen anaerobik ve mikroaerofilik İE etkenleri Propionibacterium acnes ve B. fragilis olarak tanımlanmıştır (1) . Anaerobik doğal kapak endokarditleri ender görülen fakat özel-likle ileri yaştaki hastaları etkileyen bir hastalıktır.…”

Section: Introductionunclassified

A Rare Cause Of Native Valve İnfective Endocarditis: Clostridium Histolyticum

Gülle¹,

Özel²,

Taşkıran³

et al. 2016

Terh

View full text Add to dashboard Cite

ÖZİnfektif endokardit kalp kalp iç yüzey endotelini ve kalp kapaklaının enfeksiyöz nedenli tutulumudur. Etkenler sıklıkla streptokoklardan antibiyotik dirençli bakterilerden oluşmakla birlikte ender olarak mantar ve parazitlere bağlı da gelişebilmekte-dir. Anaerobik bakteriler infektif endokardit etkeni olarak düşük oranda görülmesi-ne (%2-16) karşın, önemli bir klinik yere sahiptir. En sık görülen anaerobik ve mikroaerofilik İE etkenleri Propionibacterium acnes ve B. fragilis olarak tanımlanmıştır. Anaerobik doğal kapak endokarditleri ender görülen fakat özellikle ileri yaştaki hastaları etkileyen bir hastalıktır. Bu olgu sunumunda 67 yaşında kadın hastada saptanan Clostiridium histolyticum bakterisine bağlı gelişen doğal mitral kapak endokarditi ve buna sekonder posteromedial papiller kas rüptürü ve mitral yetmezlik tablosunu sunmak istedik. Anahtar kelimeler: İnfektif endokardit, Clostridium histolyticum, papiller kas rüptürü ABSTRACTInfective endocarditis is a disease of the inner lining of the heart and cardiac valves, the endocardium, caused by a variety of infectious agents, ranging from streptococci to antibiotic-resistant bacteria, including fungi and parasites. Although anaerobic bacteria are less frequently seen cause of infective endocarditis, they have significant clinical place accounting for 2-16% of all cases. Most cases of anaerobic IE are caused by the anaerobic and microaerophilic streptococci Propionibacterium acnes and B. fragilis. Anaerobic IE is rare cause of naive valve endocarditis which is especially seen in elderly patients. We decided to report 67-year-old woman with native mitral valve endocarditis, posteromedial papillary muscle rupture and severe mitral regurgitation due to Clostiridium histolyticum bacteria.

show abstract

“…Of the reported cases of Fusobacterium spp IE, 77 percent seeded from head and neck infections and 20 percent occurred in the setting of IV drug use. Most cases of IE caused by F. necrophorum have originated from the head and neck with one reported case in a patient with polymicrobial IE secondary to intravenous drug use (IVDU) 1,6,9,12 . Interestingly, a recent report of a fatal case of mitral valve endocarditis caused by F. necrophorum in a 20 year-old female without clinical or postmortem autopsy findings that could point to an originating source 2 .…”

Section: Discussionmentioning

confidence: 99%

“…There is increasing evidence for F. necrophorum as a cause of endemic pharyngitis in adolescents and young adults with an estimated incidence that could parallel that of the group A Streptococcus 5 . F. necrophorum may also cause intraabdominal infections, peritonitis, septic arthritis, brain abscesses and less frequently, infective endocarditis (IE) [6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Fusobacterium necrophorum causing infective endocarditis and liver and splenic abscesses

Handler¹,

Miriovsky²,

Gendelman³

et al. 2011

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYA 25-year-old male without prior co-morbidities was admitted to hospital with Fusobacterium necrophorum bacteremia, where he was found to have liver and splenic abscesses. Further evaluation with echocardiography revealed a bicuspid aortic valve with severe insufficiency and a 1.68 x 0.86 cm vegetation. The patient required abscess drainage, intravenous antimicrobial therapy and aortic valve replacement. Complete resolution of the infection was achieved after valve replacement and a prolonged course of intravenous antimicrobial therapy. A brief analysis of the patient's clinical course and review of the literature is presented.

show abstract

Anaerobic Bacterial Endocarditis

Cited by 164 publications

References 17 publications

Multiple Bacteria in Calcific Aortic Valve Stenosis

Multiple Bacteria in Calcific Aortic Valve Stenosis

A Rare Cause Of Native Valve İnfective Endocarditis: Clostridium Histolyticum

Fusobacterium necrophorum causing infective endocarditis and liver and splenic abscesses

Contact Info

Product

Resources

About