Anaerobic bacteria in oral infections

Sabiston, Charles B.; Gold, William

doi:10.1016/0030-4220(74)90054-1

Cited by 61 publications

(20 citation statements)

References 7 publications

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“…There is increasing eviilence that destructive periodontitis is associated with a pocket flora characterized by its ptedoiniriance of gram-negative an:ictobic roils anil spirochaetes (2). Of the former, Fusobacterium nucleatum (FN) is a frequent isolate from adult periodontitis sites (2^), and has also been implicated as an opportunistic pathogen in other oral disease entities (5). Recent evidence (6) suggests that this organism may induce local and/or systemic inimunosuppression, mediated by either a direct effect on T lymphocyte mitogenesis or via altered T helper cell activity.…”

mentioning

confidence: 99%

Modulation of HLA‐DR antigens in the gingival epithelium in vitro by heat‐killed Fusobacterium nucleatum and E. coli lipopolysaccharide

Walsh

Seymour

Bird

et al. 1985

J Oral Pathology Medicine

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The in vitro influence of the periodontopathic organism Fusobacierium nucleatum (FN) on gingival tissue was examined using an organ culture system. Treatment of gingival explains obtained from periodontally diseased sites with suspensions of FN, stimulated the expression of HLA‐DR antigens by Langerhans cells (LC) in a dose‐dependent fashion, and produced a maintenance of the LC markers Td and ATPase. Similar effects were seen when E. coli lipopolysaceharide (LPS) was substituted for suspensions of FN. With both FN and LPS the expression of HLA‐DR by gingival keratinocytes was maintained throughout the 72‐h culture period, de‐spite the cytotoxic effects of these agents. Using a variety of immunohistological techniques and a monoclonal antibody specific for the strain of FN used, it was possible to demonstrate the uptake of FN antigens by LC within the gingival epithelium.

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mentioning

confidence: 99%

Modulation of HLA‐DR antigens in the gingival epithelium in vitro by heat‐killed Fusobacterium nucleatum and E. coli lipopolysaccharide

Walsh

Seymour

Bird

et al. 1985

J Oral Pathology Medicine

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“…Penicillin has been recognized as the drug of choice for pyogenic dental infections 7,21,30,31 . Most strains of B. fragilis are relatively resistant to penicillin but B. melaninogenicus species and Fusobacterium spp are usually penicillin-sensitive as other investigators have reported 32 .…”

Section: Resultsmentioning

confidence: 99%

“…With modern anaerobic culture methods, the importance of anaerobic bacteria in dental infections is now being recognized. Relatively few studies performed by accurate aerobic and anaerobic culture techniques have been reported 7,[19][20][21][22] . The predominance of mixed aerobic-anaerobic cul- tures has been confirmed in all these studies.…”

Section: Resultsmentioning

confidence: 99%

“…Aerobic and facultative anaerobic bacteria have traditionally been considered as the major pathogens in dental infections. Improvement of laboratory techniques facilitates isolation and identification of anaerobic bacteria and it is now well documented that these bacteria are responsible for a significant number of clinical infections [3][4][5][6][7][8] . However, the literature indicates that the bacteria responsible for orofacial infections are staphylococci, streptococci and enterococci 9 .…”

Section: Introductionmentioning

confidence: 99%

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Periapical Abscesses: Causal Bacteria and Antibiotic Sensitivity

Goumas¹,

Naxakis²,

Papavasiliou³

et al. 1997

Journal of Chemotherapy

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The purpose of this study was to investigate the aerobic and anaerobic flora of periapical abscesses and evaluate their susceptibility to various antibiotics. In 52 patients, with a diagnosis of periapical abscesses, pus cultures were taken. Forty-two aerobes and 122 anaerobes were revealed, with 2 or more than 2 anaerobic strains isolated in 36 patients. Infections were purely aerobic in 6%, purely anaerobic in 17% and mixed in 75%, while in 2% of the specimens there was no growth of microorganisms. Among anaerobes, microorganisms from the Bacteroides group (38.5%), Peptostreptococcus spp. (24.6%), Peptococcus spp. (13.9%), and Fusobacterium spp. (4.1%), predominated in all cultures. Among aerobes the most prevalent bacteria were streptococci (47.6%) followed by staphylococci (35.6%) while Enterobacteriaceae were isolated in 4.8% of specimens. Selected susceptibility tests performed on several anaerobic species revealed that nitroimidazole derivatives, chloramphenicol and clindamycin retain their broad spectrum killing activity against anaerobes, followed by cefoxitin and moxalactam. Of the newer quinolones, ofloxacin was the most effective. It is evident that the high isolation rate of anaerobic bacteria should influence empiric therapeutic decisions.

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“…Both aerobic and anaerobic microorganisms are susceptible to penicillin [9] . Penicillinase-resistant penicillin or an ampicillinlike derivative is prescribed for infections caused by penicillinase-producing staphylococci or those involving Antibiotics are frequently used in dental practice.…”

Section: Antibiotics For Odontogenic Infectionsmentioning

confidence: 99%