Anaemia in patients with self-reported use of iron supplements in the BAriatric surgery SUbstitution and nutrition study: A prospective cohort study

Lenér, Frida; Höskuldsdóttir, Gudrún; Landin‐Wilhelmsen, Kerstin; Björkelund, Cecilia; Eliasson, Björn; Fändriks, Lars; Wallenius, Ville; Engström, My; Mossberg, Karin

doi:10.1016/j.numecd.2023.02.008

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…The non-attendees were those who were deceased, did not reply or could not be traced, declined consent, or failed to appear in the clinic [18]. This population sample has previously been used as a reference population for the BASUN cohort [22,23].…”

Section: Controlsmentioning

confidence: 99%

Effects of medical and surgical treatment on vitamin D levels in obesity

Mejaddam,

Höskuldsdóttir,

Lenér

et al. 2023

PLoS ONE

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Introduction Persons living with obesity treated with bariatric surgery are at a high risk of developing nutritional deficiencies. The primary aim of this observational cohort study was to compare vitamin D levels in patients two years after bariatric surgery (Roux-en-Y gastric bypass/RYGB and sleeve gastrectomy/SG) with a very low-energy diet (VLED). The same subjects were also compared with a population sample from the same region at baseline. The primary hypothesis was that surgery, especially RYGB, would lead to an increased prevalence of vitamin D deficiency compared to subjects treated with VLED. 971 individuals eligible for surgical, RYGB (n = 388), SG (n = 201), and medical treatment (n = 382), in routine care, were included consecutively between 2015 and 2017. A random population sample from the WHO-MONICA project was used as a reference, (n = 414). S-calcium, S-25(OH)D (vitamin D), and S-PTH (parathyroid hormone) were measured in all persons with obesity at baseline and two years after treatment (n = 713). Self-reported use of vitamin D and calcium supplementation was registered. Results Vitamin D deficiency (S-25(OH)D <25mmol/l) was found in 5.2% of the persons with obesity at baseline versus 1.7% of the general population (SMD>0.1). S-25(OH)D increased for all treatment groups but was higher in RYGB and SG (SMD>0.1, standardized mean difference). Thirteen subjects (1.8%) had vitamin D deficiency after obesity treatment. Conclusion Surgical intervention for obesity followed by vitamin D supplementation was not associated with a higher risk for vitamin D deficiency, irrespective of surgery type, compared to individuals on medical treatment. However, persons living with obesity seeking weight loss treatment are more likely to have deficient vitamin D levels compared to the general population.

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Section: Controlsmentioning

confidence: 99%

Effects of medical and surgical treatment on vitamin D levels in obesity

Mejaddam,

Höskuldsdóttir,

Lenér

et al. 2023

PLoS ONE

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Iron homeostasis in obesity and metabolic and bariatric surgery: a narrative review

Benotti,

Kaberi-Otarod,

Wood

et al. 2024

Surgery for Obesity and Related Diseases

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Iron Treatment in Patients with Iron Deficiency Before and After Metabolic and Bariatric Surgery: A Narrative Review

Kaberi-Otarod,

Still,

Wood

et al. 2024

Nutrients

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Iron is an essential nutrient in living organisms with multiple vital functions. Iron deficiency (ID) can cause long term health consequences beyond iron deficiency anemia (IDA). The high prevalence of ID and its long-term effects in patients with obesity and after metabolic and bariatric surgery (MBS) is recognized. Nevertheless, there is limited knowledge of the optimal route or dose for treatment of patients with obesity and post-MBS, and an evidence-based universal guideline for prevention and treatment of ID in short- and long-term PMBS is not yet available. ID in the general population is currently treated with oral or parenteral iron, where oral iron treatment is considered the preferred option with parenteral iron as a second-line treatment in case there is intolerance or lack of response to oral iron. In patients with obesity with chronic low-grade inflammation and patients post-MBS (PMBS) with altered gut anatomy and function, there are also alterations in the bioavailability and higher risks of side effects of available oral irons. The conclusions of current studies exploring effective treatment of iron deficiency in this population have been inconsistent and further well-planned randomized and prospective studies are needed. This is a narrative review of the literature on the available treatment options and strategies for treatment of ID in PMBS patients to recognize the knowledge gaps and provides topics of future research.

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Anaemia in patients with self-reported use of iron supplements in the BAriatric surgery SUbstitution and nutrition study: A prospective cohort study

Cited by 3 publications

References 27 publications

Effects of medical and surgical treatment on vitamin D levels in obesity

Effects of medical and surgical treatment on vitamin D levels in obesity

Iron homeostasis in obesity and metabolic and bariatric surgery: a narrative review

Iron Treatment in Patients with Iron Deficiency Before and After Metabolic and Bariatric Surgery: A Narrative Review

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