Anaemia in Infancy: Its Prevalence and Prevention

Mackay, Helen M. M.

doi:10.1136/adc.3.15.117

Cited by 99 publications

(31 citation statements)

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“…The earliest clinical report is that of MacKay in 1928 (28). He reported that infants from poor families in London had a modest decrease in bronchitis and gastroenteritis when they received iron supplementation.…”

Section: Iron Deficiency and Infectionmentioning

confidence: 99%

Functional consequences of iron deficiency in human populations.

Scrimshaw

1984

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Section: Iron Deficiency and Infectionmentioning

confidence: 99%

Functional consequences of iron deficiency in human populations.

Scrimshaw

1984

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Other studies show the opposite, i.e. morbidity is higher in iron de®cient children and is reduced by iron supplementation (McKay, 1928;Andelman & Sered, 1966;Beisel, 1982), whereas some studies do not show any effect of iron supplementation or forti®cation on incidence of infections (Harvey et al, 1989;Heresi et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Effect of daily iron supplementation on iron status, cell-mediated immunity, and incidence of infections in 6–36 month old Togolese children

Berger

Dyck²,

Galán³

et al. 2000

Eur J Clin Nutr

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Objective: To assess the impact of a daily oral iron supplementation on hematological status, cell-mediated immunity and susceptibility to infections in children living in an environment where iron de®ciency, malaria and other infections are frequent. Design: Randomized, double-blind iron supplementation including a placebo group. Setting: A village in Togo, West Africa. Subjects: Of the 229 6 ± 36-month-old children of both sexes recruited, 197 with hemoglobin concentration ! 80 gal were included and 163 completed the study. Intervention: Children received daily a placebo (n 79) or a dose of 2 ± 3 mg of elemental iron per kg of body weight (n 84) for 3 months. Hematological, nutritional and immune status were assessed at the beginning and at the end of the supplementation period, and 6 months later. Morbidity was recorded throughout the study. Results: Iron supplementation had a signi®cant and positive effect on iron status of children and no impact on the incidence of infections, especially malaria. Its probable effect on immune status was masked by interference of infections and their treatment, which contributed to improve hematological and immune status in both groups. Conclusion: According to the negative consequences of anemia and iron de®ciency on global child development, control of iron de®ciency by oral iron supplementation in young children has to be conducted, associated with prophylaxis and treatment of malaria and repeated deworming.

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“…After working in Vienna post-World War I, Helen Mackay, the first woman to receive the fellowship of the Royal College of Physicians of London, studied young children in East London in the 1920s to determine 'normal' haemoglobin values for different stages of infancy (Mackay, 1928(Mackay, , 1931. Mackay (1931) showed high haemoglobin levels at birth, a gradual fall from birth to around 2 months and then (in Mackay's infants), a steady level until further falls from 6 months into the second year.…”

Section: Helen Mackay and The Children Of East Londonmentioning

confidence: 99%

“…In earlier studies, Mackay (1928) had found that infants attending her clinics gained weight when treated for infection and given supplementary milk. These interventions had not prevented the decline in haemoglobin levels.…”

Section: Helen Mackay and The Children Of East Londonmentioning

confidence: 99%

“…The late anaemia of infancy (that is after the physiological post-natal fall) was either prevented or, when iron was started after 6 months, diminished in iron-supplemented infants compared with those not receiving supplementary iron (Fig 5). Mackay (1928Mackay ( , 1931) also remarked that iron-treated infants looked much healthier. Ironsupplemented infants had only around 50% of the episodes of respiratory tract infection, diarrhoea and specific fevers experienced by the unsupplemented infants.…”

Section: Helen Mackay and The Children Of East Londonmentioning

confidence: 99%

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