Anaemia from a patient perspective in inflammatory bowel disease

Abstract

IBD patients are mostly aware of the main signs and symptoms of anaemia. Oral iron is most commonly prescribed, but may cause dissatisfaction because of tolerability issues. Most patients prescribed intravenous iron are satisfied with treatment.

Intravenous Versus Oral Iron for the Treatment of Anemia in Inflammatory Bowel Disease

“…According to GRADE, the quality of evidence (certainty of associations) in this review is moderate. This evidence, along with the treatment costs, patients’ values and preferences, 45 and other factors (clinical disease activity, severity of anemia, and previous intolerance to oral iron) should be considered to inform clinical decision making. Nevertheless, further high-quality (and adequately powered) randomized research, with clearly defined patient populations (eg, UC or CD, with mild, moderate, or severe anemia, etc.…”

Diagnosis and treatment of anemia in patients with inflammatory bowel disease

“…In contrast, in recent years the topic has moved into the spotlight, because there is a growing body of evidence that anemia plays a key role in affecting IBD patients’ quality of life (QOL). In 2014, Danese et al analyzed anemia-related symptoms from an IBD patient’s perspective [15]. Symptoms widely reported by the 613 participants included fatigue, weakness, difficulties in concentrating, depressive mood, breathlessness, and sleeping difficulties.…”

“…For example, Blumenstein et al revealed that in Germany 56.5% of IBD patients with anemia had not received adequate treatment [19]. Likewise, a web-based questionnaire of IBD patients showed that one third of those with anemia had not been treated accordingly [15]. Additionally, in a recent survey across 9 European countries, Stein et al revealed a high frequency of iron deficiency (ID) among IBD patients [20].…”

“…For these reasons, intravenous iron supplementation is currently still favored in IBD patients with ID anemia, especially in cases of severe anemia (Hb<10 g/L), or inadequate response to or intolerance of oral supplementations [80,81], not least because it is well-tolerated by most patients [15]. Furthermore, intravenously administered iron does not deteriorate disease activity in IBD patients [80,82].…”

Antitumor Drug Combretastatin-A4 Phosphate Aggravates the Symptoms of Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

“…UC is associated with an architectural distortion of the intestinal epithelium and impaired mucosal barrier function (Chen et al, 2014;Zhang et al, 2017a). Patients with UC generally exhibit undesirable symptoms, such as fatigue, diarrhea, and rectal bleeding (blood in the stool) (Danese et al, 2014). Disease recurrences may affect the innermost layer of the large intestine and rectum, increasing the prevalence of colorectal cancer and the risk of extraintestinal diseases, such as iritis/uveitis, arthritis, major sclerosing cholangitis, and ankylosing spondylitis (Vavricka et al, 2015;Harbord et al, 2016).…”