Anaemia due to gastric haemorrhage by a metastatic Merkel cell carcinoma

Santos‐Juanes, Jorge; Palomo, Carmen; Rodrigo, Luı́s; Fernández‐Vega, Iván

doi:10.5114/pg.2015.51183

Cited by 4 publications

(4 citation statements)

References 12 publications

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“… 6 7 Metastasis of MCC to the stomach is extremely uncommon and a rare presentation of disease progression; only a few case reports are available in the published literature. 4 8 9 10 11 12 13 Due to its rarity, there may be a delay in correctly diagnosing this metastatic disease and subsequent delay in further systemic treatment. The life expectancy ranges from 1 week to 1 year with an average mortality rate of 67% at 4 months following the diagnosis of gastric metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…The life expectancy ranges from 1 week to 1 year with an average mortality rate of 67% at 4 months following the diagnosis of gastric metastasis. 8 9 10 11 12 13 There is no unanimous treatment protocol for patients with GI metastasis. Primary treatment of MCC is wide resection.…”

Section: Discussionmentioning

confidence: 99%

“…The use of partial gastrectomy (wide resection preferred over radical surgery) along with radiotherapy/chemotherapy including various platinum-based drugs is controversial and very few case reports have illustrated their use. 8 9 10 11 12 13 …”

Section: Discussionmentioning

confidence: 99%

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Gastric Metastasis of Primary Neuroendocrine Tumor of Skin: Rare Tumor with Rare Presentation

et al. 2023

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Merkel cell carcinoma (MCC) is a rare primary neuroendocrine tumor of the skin. It has an aggressive biological behavior and shows early local and distant metastasis. Diagnosis of MCC is a challenge and requires confirmation by immunohistochemistry (IHC). However, metastasis of MCC to the stomach is extremely uncommon and is rarely reported in the literature. We hereby describe a patient with gastric metastasis of MCC, who presented with black tarry stool and was finally diagnosed on the basis of clinical history, histology, and IHC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gastric Metastasis of Primary Neuroendocrine Tumor of Skin: Rare Tumor with Rare Presentation

et al. 2023

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“…Only cases of gastric metastasis from MCC, in the absence of further confounding conditions, were selected. At the end, 20 publications have been considered relevant for the research query (Figure 1) [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. The information available for each clinical case (including the case report described herein) regarding the age, gender, ethnicity, primary site, therapy for primary site, time between initial diagnosis/therapy and metastasis presentation, management of metastasis, outcome at time of report, time between metastatic diagnosis and death have been collected and compared.…”

Section: Methodsmentioning

confidence: 99%

Merkel Cell Carcinoma with Gastric Metastasis, a Rare Presentation: Case Report and Literature Review

Durastante¹,

Conte²,

Brollo

et al. 2022

J Gastrointest Canc

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Merkel cell carcinoma (MCC) is an infrequent, but highly aggressive neuroendocrine neoplasm of the skin with a propensity for recurrence and metastasis. We report a rare case of gastric metastatic localization of this cancer by focusing on the diagnostic, clinical and surgical approach to the patient. Case report.Clinical presentation begins with a peripheral lymphadenopathy whose immunohistochemical characterization identi es the lymphatic dissemination of the disease. Gradually the patient develops a severe anaemic state which requires several blood transfusions and surgical gastric resection to remove a large bleeding lesion of the antral region. The histopathological analysis of the specimen con rms the metastatic origin from MCC, but the primitive lesion remains unknown. Discussion.Since this clinical situation is very rare, we conducted a review of the literature selecting the few cases reported, in order to evaluate the current knowledge on this topic. Metastatic involvement of the stomach from Merkel cell carcinoma is a rare presentation of this disease progression with a frequent delay in formulating the correct diagnosis and in further treatment which may be life-threatening for the patient. As regards the local treatment, there is no speci c guideline, and the therapeutic indication should be tailored on the speci c case.

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Merkel Cell Carcinoma With Gastric Metastasis, A Rare Presentation: Case Report and Literature Review

Durastante

Conte

Brollo

et al. 2021

Preprint

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Introduction. Merkel cell carcinoma (MCC) is an infrequent, but highly aggressive neuroendocrine neoplasm of the skin with a propensity for recurrence and metastasis. We report a rare case of gastric metastatic localization of this cancer by focusing on the diagnostic, clinical and surgical approach to the patient. Case report. Clinical presentation begins with a peripheral lymphadenopathy whose immunohistochemical characterization identifies the lymphatic dissemination of the disease. Gradually the patient develops a severe anaemic state which requires several blood transfusions and surgical gastric resection to remove a large bleeding lesion of the antral region. The histopathological analysis of the specimen confirms the metastatic origin from MCC, but the primitive lesion remains unknown. Discussion. Since this clinical situation is very rare, we conducted a review of the literature selecting the few cases reported, in order to evaluate the current knowledge on this topic. Metastatic involvement of the stomach from Merkel cell carcinoma is a rare presentation of this disease progression with a frequent delay in formulating the correct diagnosis and in further treatment which may be life-threatening for the patient. As regards the local treatment, there is no specific guideline, and the therapeutic indication should be tailored on the specific case.

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Anaemia due to gastric haemorrhage by a metastatic Merkel cell carcinoma

Cited by 4 publications

References 12 publications

Gastric Metastasis of Primary Neuroendocrine Tumor of Skin: Rare Tumor with Rare Presentation

Gastric Metastasis of Primary Neuroendocrine Tumor of Skin: Rare Tumor with Rare Presentation

Merkel Cell Carcinoma with Gastric Metastasis, a Rare Presentation: Case Report and Literature Review

Merkel Cell Carcinoma With Gastric Metastasis, A Rare Presentation: Case Report and Literature Review

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