Anabolic Steroids Reduce Muscle Degeneration Associated With Rotator Cuff Tendon Release in Sheep

Gerber, Christian; Meyer, Dominik C.; Flück, Martin; Benn, Mario C.; Rechenberg, Brigitte von; Wieser, Karl

doi:10.1177/0363546515596411

Cited by 58 publications

(105 citation statements)

References 26 publications

(38 reference statements)

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“…Scanning and readout analysis were performed as described previously 6. The approximate volumes of the different tissue types in the total muscle were calculated by splitting the total volume according to the percentages of fatty, contractile, and other tissue types that were assessed histologically in the biopsy specimen.…”

Section: Methodsmentioning

confidence: 99%

“…This may result in lower Ca 2+ ‐activated protease activity and thereby decreased costamere cleavage, which potentially explains protection from muscle loss 10, 12, 20. In the ovine model of RC tear, the reduction of total muscle volume after tendon release did not differ with or without nandrolone administration; although, fat accumulation was prevented by nandrolone 6. This model has been used to replicate chronic tears (e.g., at 16–40 weeks)6, 21, 22 with high intramuscular fat content (around 50%; Goutallier stage 323).…”

mentioning

confidence: 97%

“…To reestablish normal shoulder function, RC tendon tears are often surgically repaired, and the degree of muscle atrophy and fat accumulation correlates with the probability of repair failure 4, 5. Until recently, these tendon tear‐induced changes were considered irreversible 3, 6. Thus, it is important to characterize these alterations to find solutions for their prevention and treatment and allow a successful recovery from a RC tear.…”

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confidence: 99%

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Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep

Ruoss

Möhl

Benn

et al. 2017

Journal Orthopaedic Research

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Previous studies suggested that degradation of contractile tissue requires cleavage of the costamere, a structural protein complex that holds sarcomeres in place. This study examined if costamere turnover is affected by a rotator cuff tear in a previously established ovine model. We found the activity of focal adhesion kinase (FAK), a main regulator of costamere turnover, was unchanged at 2 weeks but decreased by 27% 16 weeks after surgical release of the infraspinatus tendon. This was accompanied by cleavage of the costamere protein talin into a 190 kDa fragment while full length talin remained unchanged. At 2 weeks after tendon release, muscle volume decreased by 17 cm3 from an initial 185 cm3, the fatty tissue volume was halved, and the contractile tissue volume remained unchanged. After 16 weeks, the muscle volume decreased by 36 cm3, contractile tissue was quantitatively lost, and the fat content increased by 184%. Nandrolone administration mitigated the loss of contractile tissue by 26% and prevented fat accumulation, alterations in FAK activity, and talin cleavage. Taken together, these findings imply that muscle remodeling after tendon release occurs in two stages. The early decrease of muscle volume is associated with reduction of fat; while, the second stage is characterized by substantial loss of contractile tissue accompanied by massive fat accumulation. Regulation of costamere turnover is associated with the loss of contractile tissue and seems to be impacted by nandrolone treatment. Clinically, the costamere may represent a potential intervention target to mitigate muscle loss after a rotator cuff tear. © 2017 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res 36:272–281, 2018.

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Section: Methodsmentioning

confidence: 99%

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confidence: 97%

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confidence: 99%

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Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep

Ruoss

Möhl

Benn

et al. 2017

Journal Orthopaedic Research

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“…The best way to prevent irreversible fatty infiltration and atrophy remains rotator cuff repair. In the future, it is probable that other methods of prevention and treatment in certain groups of patients, such as administration of an anabolic steroid, 53 may prevent the occurrence of these troublesome complications.…”

Section: Discussionmentioning

confidence: 99%

Classification of full-thickness rotator cuff lesions: a review

et al. 2016

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Rotator cuff lesions (RCL) have considerable variability in location, tear pattern, functional impairment, and repairability.Historical classifications for differentiating these lesions have been based upon factors such as the size and shape of the tear, and the degree of atrophy and fatty infiltration. Additional recent descriptions include bipolar rotator cuff insufficiency, ‘Fosbury flop tears’, and musculotendinous lesions.Recommended treatment is based on the location of the lesion, patient factors and associated pathology, and often includes personal experience and data from case series. Development of a more comprehensive classification which integrates historical and newer descriptions of RCLs may help to guide treatment further.Cite this article: Lädermann A, Burkhart SS, Hoffmeyer P, et al. Classification of full thickness rotator cuff lesions: a review. EFORT Open Rev 2016;1:420-430. DOI: 10.1302/2058-5241.1.160005.

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“…Rotator cuff muscle volume has been quantified by employing various imaging techniques in patients [6,11,12,17,23,24], cadavers [13,16,21,22], sheep [5] and primates [18,20]. Piepers et al [17] quantified the muscle volume correlation of the subscapularis muscle regarding the teres minor and infraspinatus in a series of 27 computed tomography scans in 21 patients, finding no significant differences among RCTFC components in healthy shoulders.…”

Section: Introductionmentioning

confidence: 99%

An age- and gender-related three-dimensional analysis of rotator cuff transverse force couple volume ratio in 304 shoulders

Espinosa-Uribe

Negreros-Osuna

et al. 2016

Surg Radiol Anat

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Anabolic Steroids Reduce Muscle Degeneration Associated With Rotator Cuff Tendon Release in Sheep

Abstract: Study findings may lead to the development of treatment strategies to prevent or reduce muscle degeneration caused by rotator cuff tendon tearing.

Cited by 58 publications

References 26 publications

Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep

Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep

Classification of full-thickness rotator cuff lesions: a review

An age- and gender-related three-dimensional analysis of rotator cuff transverse force couple volume ratio in 304 shoulders

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