Anabolic steroids and lymphocyte function in sedentary and exercise-trained rats

Ferrández, M.D.; Fuente, Mónica De la; Fernandez, Edgar D. Torres; Manso, Rafael

doi:10.1016/s0960-0760(96)00111-2

Cited by 11 publications

(8 citation statements)

References 33 publications

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“…Secondly, the rate of body‐weight increment was lower in the nandrolone decanoate‐treated groups compared to the vehicle‐treated and control groups. This finding has been observed by others as well (Ferrandez et al . 1996).…”

Section: Discussionsupporting

confidence: 90%

Chronic Administration of Nandrolone Decanoate Does Not Increase the Plasma Homocysteine Level of Male Rats

Mirkhani¹,

Golbahar

Shokri

2005

Basic Clin Pharma Tox

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Androgenic-anabolic steroids are used widely by many athletes in order to increase muscle mass and strength. Since plasma total homocysteine, an independent risk factor of vascular diseases, is higher in men than in women, it has been proposed that androgenic hormones could increase the plasma total homocysteine level and it might play some role in sudden death when used at supraphysiological doses. To study the association between the use of androgenic-anabolic steroids and plasma homocysteine level, nandrolone decanoate was administered in 3 and 10 mg/kg doses to male rats by intramuscular weekly injections. Control animals received the solvent of nandrolone decanoate. After 14 weeks, plasma total homocysteine level was measured. In order to make sure about the adequacy of doses and bioavailability of drug, testes parameters were also considered. While all testes parameters were suppressed significantly, no association between androgenic-anabolic steroids use and total homocysteine level was found.It is concluded that chronic administration of nandrolone decanoate does not have any significant effect on plasma total homocysteine of male rats. Thus, factors other than plasma total homocysteine level may contribute to increased cardiovascular events after chronic abuse of androgenic-anabolic steroids.

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Section: Discussionsupporting

confidence: 90%

Chronic Administration of Nandrolone Decanoate Does Not Increase the Plasma Homocysteine Level of Male Rats

Mirkhani¹,

Golbahar

Shokri

2005

Basic Clin Pharma Tox

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“…In this work, the weight of thymus was used as an indirect indicator of immunological functional state, with involution of thymus showing a correlation with differences in immunological function [39] and immunological aging [40]. As expected, the total weight of thymus was higher in females than in males, and this gender difference was more obvious when its relative weight was considered, suggesting a better immune function in the female gender.…”

Section: Discussionmentioning

confidence: 90%

Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice

Giménez-Llort

García

Buccieri

et al. 2010

International Journal of Alzheimer's Disease

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The 3xTg-AD mouse develops a progressive Alzheimer's disease- (AD-) like brain pathology that causes cognitive- and neuropsychiatric-like symptoms of dementia. Since its neuroimmunoendocrine axis is likewise impaired, this mouse is also useful for modelling complex age-related neurodegeneration. This study analyzed behavioral, physiological, neurochemical, pathological and immunoendocrine alterations in male and female 3xTg-AD mice and assayed the effects of a short therapy of forced physical exercise at the moderate pathology stage of 6 months of age. Gender effects were observed in most AD-related pathology and dysfunctions. Five weeks of treadmill training produced beneficial effects, such as the reduction of brain oxidative stress and GABA-A receptor dysfunction in males and improvement of sensorimotor function in females. In both sexes, exercise decreased the brain amyloid β 42/40 ratio levels. The results highlight the importance of analyzing experimental therapies in both mouse model genders in order to improve our understanding of the disease and develop more appropriate therapies.

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“…The doses of stanozolol used in the present study were based on a previous study in rats, in which stanolozol treatment (10 mg/kg week) was effective in inducing a redistribution of lymphocytes and modifying lymphocyte activity [11]. Moreover, similar doses of stanozolol caused anabolic and behavioral alterations in both female and male rats, and are considered an effective dose to increase muscle strength and size [12,13].…”

Section: Animalsmentioning

confidence: 99%

Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats

Beutel

Bergamaschi

Campos

2005

The Journal of Steroid Biochemistry and Molecular Biology

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Anabolic steroids and lymphocyte function in sedentary and exercise-trained rats

Cited by 11 publications

References 33 publications

Chronic Administration of Nandrolone Decanoate Does Not Increase the Plasma Homocysteine Level of Male Rats

Chronic Administration of Nandrolone Decanoate Does Not Increase the Plasma Homocysteine Level of Male Rats

Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice

Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats

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