Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Balgoma, David; Zelleroth, Sofia; Grönbladh, Alfhild; Hallberg, Mathias; Pettersson, Curt; Hedeland, Mikael

doi:10.1007/s11306-019-1632-0

Cited by 16 publications

(14 citation statements)

References 74 publications

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“…In a study by Gårevik et al, cholesterol level, steroid synthesizing enzymes in the adrenal gland (HMGCR) mRNA and Apo-lipoprotein B (ApoB) appeared to increase after a single dose of ND in humans, and this effect was persistent after 14 days [ 47 ]. Belgoma and colleagues [ 48 ] highlighted the molecular mechanism behind serum lipid alteration, with a downregulation of several intracellular factors that leads to the synthesis of sphingolipids and glycerolipids. AASs decrease lipogenesis by the downregulation of the activity of the lipogenic liver X receptor pathway via activation of the androgen receptor.…”

Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate: Use, Abuse and Side Effects

et al. 2020

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Background and Objectives: Androgens play a significant role in the development of male reproductive organs. The clinical use of synthetic testosterone derivatives, such as nandrolone, is focused on maximizing the anabolic effects and minimizing the androgenic ones. Class II anabolic androgenic steroids (AAS), including nandrolone, are rapidly becoming a widespread group of drugs used both clinically and illicitly. The illicit use of AAS is diffused among adolescent and bodybuilders because of their anabolic proprieties and their capacity to increase tolerance to exercise. This systematic review aims to focus on side effects related to illicit AAS abuse, evaluating the scientific literature in order to underline the most frequent side effects on AAS abusers’ bodies. Materials and Methods: A systematic review of the scientific literature was performed using the PubMed database and the keywords “nandrolone decanoate”. The inclusion criteria for articles or abstracts were English language and the presence of the following words: “abuse” or “adverse effects”. After applying the exclusion and inclusion criteria, from a total of 766 articles, only 148 were considered eligible for the study. Results: The most reported adverse effects (found in more than 5% of the studies) were endocrine effects (18 studies, 42%), such as virilization, gynecomastia, hormonal disorders, dyslipidemia, genital alterations, and infertility; cardiovascular dysfunctions (six studies, 14%) such as vascular damage, coagulation disorders, and arteriosus hypertension; skin disorders (five studies, 12%) such as pricking, acne, and skin spots; psychiatric and mood disorders (four studies, 9%) such as aggressiveness, sleep disorders and anxiety; musculoskeletal disorders (two studies, 5%), excretory disorders (two studies, 5%), and gastrointestinal disorders (two studies, 5%). Conclusions: Based on the result of our study, the most common adverse effects secondary to the abuse of nandrolone decanoate (ND) involve the endocrine, cardiovascular, skin, and psychiatric systems. These data could prove useful to healthcare professionals in both sports and clinical settings.

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Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate: Use, Abuse and Side Effects

et al. 2020

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“…A quality control sample was built by pooling 10 µL from every extract. The samples were analyzed as in Balgoma et al [ 20 ]. The samples were injected in a randomized way on an Acquity UPLC hyphenated to a Synapt G2 Q-ToF (Waters, Manchester, UK) with electrospray ionization.…”

Section: Methodsmentioning

confidence: 99%

Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Balgoma

Kullenberg

Calitz

et al. 2021

Cells

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Metabolic and personalized interventions in cancer treatment require a better understanding of the relationship between the induction of cell death and metabolism. Consequently, we treated three primary liver cancer cell lines with two anthracyclins (doxorubicin and idarubin) and studied the changes in the lipidome. We found that both anthracyclins in the three cell lines increased the levels of polyunsaturated fatty acids (PUFAs) and alkylacylglycerophosphoethanolamines (etherPEs) with PUFAs. As PUFAs and alkylacylglycerophospholipids with PUFAs are fundamental in lipid peroxidation during ferroptotic cell death, our results suggest supplementation with PUFAs and/or etherPEs with PUFAs as a potential general adjuvant of anthracyclins. In contrast, neither the markers of de novo lipogenesis nor cholesterol lipids presented the same trend in all cell lines and treatments. In agreement with previous research, this suggests that modulation of the metabolism of cholesterol could be considered a specific adjuvant of anthracyclins depending on the type of tumor and the individual. Finally, in agreement with previous research, we found a relationship across the different cell types between: (i) the change in endoplasmic reticulum (ER) stress, and (ii) the imbalance between PUFAs and cholesterol and saturated lipids. In the light of previous research, this imbalance partially explains the sensitivity to anthracyclins of the different cells. In conclusion, our results suggest that the modulation of different lipid metabolic pathways may be considered for generalized and personalized metabochemotherapies.

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“…A quality control sample was built by pooling 10 µL from every extract. The samples were analyzed as in Balgoma et al 21 . The samples were injected in a randomized way on an Acquity UPLC hyphenated to a Synapt G2 Q-ToF (Waters) with electrospray ionization.…”

Section: Lipidomics Analysis and Data Pre-treatmentmentioning

confidence: 99%

“…The quality control pool was injected every five injections of samples. Lipids were identified as in Balgoma et al 21 by the m/z of their adducts and their patterns of fragmentation. Due to the number of lipids, only the key species are represented in the main text.…”

Section: Lipidomics Analysis and Data Pre-treatmentmentioning

confidence: 99%

Anthracyclins increase free PUFAs and etherPEs with PUFAs as potential hallmarks of lipid peroxidation and ferroptosis

Balgoma

Kullenberg

Calitz

et al. 2021

Preprint

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Metabolic and personalized interventions in cancer treatment require a better under-standing of the relationship between the induction of cell death and metabolism. Consequently, we treated three primary liver cancer cell lines with two anthracyclins (doxorubicin and idarubin) and studied the changes of the lipidome. We found that both anthracyclins in the three cell lines increased the levels of polyunsaturated fatty acids (PUFAs) and alkylacylglycerophosphoethano-lamines (etherPEs) with PUFAs. As PUFAs and alkylacylglycerophospholipids with PUFAs are fundamental in lipid peroxidation during ferroptotic cell death, our results suggests supplementa-tion with PUFAs and/or etherPEs with PUFAs as a potential general adjuvant of anthracyclins. In contrast, neither the markers of de novo lipogenesis nor cholesterol lipids presented the same trend in all cell lines and treatments. In agreement with previous research, this suggests that modulation of the metabolism of cholesterol could be considered a specific adjuvant of anthracyclins depend-ing on the type of tumor and the individual. Finally, we discuss the changes in the lipidome in re-lation to the endoplasmic reticulum stress and the sensitivity to anthracyclins of the different cells. In conclusion, our results suggest that the modulation of different lipid metabolic pathways may be considered for generalized and personalized metabochemotherapies.

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Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver

Cited by 16 publications

References 74 publications

Nandrolone Decanoate: Use, Abuse and Side Effects

Nandrolone Decanoate: Use, Abuse and Side Effects

Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Anthracyclins increase free PUFAs and etherPEs with PUFAs as potential hallmarks of lipid peroxidation and ferroptosis

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