Anabolic-androgenic steroids: a possible new risk factor of toxicant-associated fatty liver disease

Abstract

These results suggest that AAS could be a possible new risk factor for TAFLD. In this type of fatty liver disease, the individuals had a low body fat mass and they did not present insulin resistance.

The dark side of sports: using steroids may harm your liver

“…The present study by Schwingel et al (6) has some methodological limitations. First, it evaluates several different types of AAS, half of them 17-a alkylated and the others not.…”

“…The concept of TAFLD was introduced as an expansion of toxicant-associated steatohepatitis, a term coined by Cave et al (7) to describe the association of steatohepatitis with a toxic, vinyl chloride. Definition of TALFD required the consumption of AAS for at least 2 years, presence of hepatic steatosis on ultrasound and/or aminotransferase elevation with normal creatine phosphate kinase (CPK) and exclusion of other liver diseases, including a restriction of 20 g/day of alcohol consumption, even in men (6). All patients were asymptomatic, but there was a 6-fold increase of TAFLD among AAS users (12.6 vs 2.4%, P o 0.05), even though patients with TAFLD were younger than controls.…”

Steroid Prohormones: Effects on Body Composition in Athletes

“…Even though usage has decreased by over 50% since 1989, steroid use in sport is still a serious problem. Insufficient knowledge and inappropriate attitudes regarding the benefits and risks of using anabolic steroids is also a major concern (Schwingel et al 2011). …”

Chronic High Doses of Nandrolone Decanoate on Blood Cell, Lipoprotein Profile, and Liver Enzymes in Male Rats

“…Moreover, low-dose administration of a considerable number of androgens alters hemoglobin concentrations, while producing potent hypertrophy actions in skeletal muscle [4]. The investigation showed that the use of anabolicandrogenic steroids (AAS) could also be a risk factor to toxicant-associated with fatty liver disease [5]. Combination therapy of Erythropoietin, ND and low-dose of methylprednisolone can be effective as an alternative treatment for Red Blood Cells (RBC) transfusion-dependent to the refractory anemia [6].…”

“…The biochemical studies indicated that ND administration cause increase in serum levels of the AST, ALT, and ALP [12]. The studies revealed that the use of anabolicandrogenic steroids (AAS) could also be a risk factor to toxicant-associated fatty liver disease development [5]. The utilization of ND would agree to us a satisfactory management of anemia in addition to an improved nutritional stipulation in old male patients on dialysis [13].…”