Background: Nandrolone decanoate (ND) is a doping agent and it is used by athletes. Objectives: This study was carried out to evaluate the chronic, high doses of ND administration on Blood cell, lipid profile, and Liver enzymes in male rats. Materials and Methods: This experiment was executed on 30 wistar-Albino male rats divided, after weighing, in control, placebo, and test groups (n = 10). Test group received 15 mg/kg intramuscular (IM) ND for duration of 8 weeks. Group placebo received the same volume of placebo although control group did not receive any agent during the trial period. At the end, animals were anesthetized by diethyl ether, scarified, and then blood samples were collected from cervical vessels immediately. Blood cell, lipoprotein profile, and liver enzymes were measured by ordinary methods. Obtained data were analyzed by SPSS V. 15, via ANOVA and Tukey test.