Anabolic and Catabolic Pathways of Parathyroid Hormone on the Skeleton

CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo

“…6). PTH is known to exhibit both catabolic and anabolic effects on bone [40,41]. The difference in PTH effect on bone depends on the regimen of PTH administration and concentration [40,41].…”

International Union of Basic and Clinical Pharmacology. XCIII. The Parathyroid Hormone Receptors—Family B G Protein–Coupled Receptors

“…The hormone is secreted from the parathyroid gland as blood Ca 2+ levels fall below a set point level, which in humans is ;1.2 6 0.1 mM, and then acts on specific bone and kidney cells to increase their rates of calcium mobilization. In bone, PTH acts on surface osteoblasts as well as on the bone-embedded osteocytes, and these cells respond by producing the receptor activator of nuclear factor-kB ligand, which, in turn, acts on osteoclasts to stimulate their rates of bone matrix resorbtion and mineral release (Silva et al, 2011;Boyce et al, 2012;O'Brien et al, 2013;Saini et al, 2013). In the kidney, PTH acts on cells of the distal tubules to increase their rates of Ca reabsorption via effects on calcium transport proteins, including the transient receptor potential vanilloid type V channel active on the lumenal cell surface (van Abel et al, 2005;de Groot et al, 2009).…”

Comparison of treatment effects of teriparatide and the bisphosphonate risedronate in an aged, osteopenic, ovariectomized rat model under various clinical conditions

“…PTH also promotes osteoclast differentiation by regulating the expression of both the receptor activator of nuclear factor kappa B ligand and osteoprotegerin, thereby promoting bone resorption [14]. Additionally, intermittent PTH administration induces strong anabolic effects in bone [15].…”