Anabolic Actions of a Mixed β-Adrenergic Agonist on Nitrogen Retention and Protein Turnover

Ja, Martínez; Portillo, MP; Larralde, J

doi:10.1055/s-2007-1003762

Cited by 14 publications

(6 citation statements)

References 11 publications

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“…The lower blood ammonia levels during submaximal exercise observed after b-adrenoreceptor stimulation in the present study could be explained by decreased amino acid catabolism. Although it is not demonstrated that acute stimulation of b-adrenoreceptors results in decreased amino acid catabolism, chronic administration of a b-adrenergic agonist has been shown to reduce muscle protein degradation in rats (Martinez et al 1991). We hypothesise that b-adrenoreceptor stimulation during exercise would increase the availability in carbohydrates and fat as fuel insofar as amino acids (BCAA) do not have to be used.…”

Section: Discussionmentioning

confidence: 94%

Inhaled salbutamol decreases blood ammonia levels during exercise in normal subjects

Matthys

Pannier

1998

European Journal of Applied Physiology

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The present study examines the effect of salbutamol, a beta2-adrenoreceptor agonist, on blood ammonia levels during an incremental cycle exercise test in healthy non-asthmatic subjects. Blood ammonia levels were lower after inhalation of 400 mcg of salbutamol than after placebo during submaximal exercise: 33+/-2 micromol x l(-1) v.s. 48+/-9 micromol x l(-1) at 220 W and 39+/-2 micromol x l(-1) v.s. 50+/-4 micromol x l(-1) at 260 W. At peak exercise there were no significant differences. The results suggest that beta2-adrenoreceptors are involved in the regulation of blood ammonia during exercise.

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Section: Discussionmentioning

confidence: 94%

Inhaled salbutamol decreases blood ammonia levels during exercise in normal subjects

Matthys

Pannier

1998

European Journal of Applied Physiology

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“…However, the subsequent events leading to anabolic actions in muscle protein deposition remain unclear. Hypothesized mechanisms include alterations in resting potential, Ca 2 + myosin ATPase and contractile properties [22], and several indirect mechanisms such as changes in hormonal profile and in protein synthesis or reduction in muscle protein degradation [14] have been proposed. This anabolic effect on skeletal muscle was, however, only found after IV salbutamol administration with implanted minipumps [4].…”

Section: Discussionmentioning

confidence: 99%

Effects of Short-Term Salbutamol Ingestion During a Wingate Test

Panse¹,

Collomp²,

Portier³

et al. 2005

Int J Sports Med

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The effects of a chronic salbutamol intake (SAL, 12 mg/d during 3 weeks) on changes in body composition, metabolic indices and performance during a 30-second Wingate test were determined in 8 strength-trained male athletes (T) and 7 sedentary male (UT) subjects, according to a double-blind, randomized, cross-over protocol. Blood samples were collected both at rest, at the end of the test, and during passive recovery (5 min, 10 min, 15 min) for leptin (at rest), and blood lactate measurements. No significant changes in lean body mass, fat mass, and leptin were observed with SAL treatment in either group during the trial. Peak power was significantly increased (p < 0.05) after SAL intake in all subjects (T: 11.9 %; UT: 8.3 %) with a decrease in time to peak power with SAL compared to placebo (PLA) (p < 0.05). There was no change in total work performed and in fatigue indices with SAL compared to PLA. Blood lactate was significantly increased after SAL vs. PLA during the recovery (p < 0.05) in all subjects. The data demonstrate that the chronic administration of therapeutic levels of salbutamol increases maximal anaerobic power in man, irrespective of the subjects' training status. This study also rules out any implication of an anabolic effect in this improvement in performance during supramaximal exercise. Further studies are necessary to clarify the mechanisms involved.

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“…terations in resting potential, Ca 2ϩ myosin ATPase, and contractile properties (36), and several indirect mechanisms such as changes in hormonal profile and in protein synthesis or reduction in muscle protein degradation (19) have been proposed. To our knowledge, the pharmacological properties of Sal, regarding cortisol and testosterone response, have not been considered.…”

Section: Discussionmentioning

confidence: 99%

Effects of short-term oral salbutamol administration on exercise endurance and metabolism

Collomp¹,

Candau²,

Lasne³

et al. 2000

Journal of Applied Physiology

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The present study examined whether oral short-term administration of salbutamol (Sal) modifies performance and selected hormonal and metabolic variables during submaximal exercise. Eight recreational male athletes completed two cycling trials at 80-85% peak O(2) consumption until exhaustion after either gelatin placebo (Pla) or oral Sal (12 mg/day for 3 wk) treatment, according to a double-blind and randomized protocol. Blood samples were collected at rest, after 5, 10, and 15 min, and at exhaustion to determine growth hormone (GH), cortisol, testosterone, triiodothyronine (T(3)), C peptide, free fatty acid (FFA), blood glucose, lactate, and blood urea values. Time of cycling was significantly increased after chronic Sal intake (Sal: 30.5 +/- 3.1 vs. Pla: 23.7 +/- 1.6 min, P < 0.05). No change in any variable was found before cycling except a decrease in blood urea concentration and an increase in T(3) after Sal that remained significant throughout the exercise test (P < 0.05). Compared with rest, exercise resulted in a significant increase in GH, cortisol, testosterone, T(3), FFAs, and lactate and a decrease in C peptide after both treatments with higher exercise FFA levels and exhaustion GH concentrations after Sal (P < 0.05). Sal but not Pla significantly decreased exercise blood glucose levels. From these data, short-term Sal intake did appear to improve performance during intense submaximal exercise with concomitant increase in substrate availability and utilization, but the exact mechanisms involved need further investigation.

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Anabolic Actions of a Mixed β-Adrenergic Agonist on Nitrogen Retention and Protein Turnover

Cited by 14 publications

References 11 publications

Inhaled salbutamol decreases blood ammonia levels during exercise in normal subjects

Inhaled salbutamol decreases blood ammonia levels during exercise in normal subjects

Effects of Short-Term Salbutamol Ingestion During a Wingate Test

Effects of short-term oral salbutamol administration on exercise endurance and metabolism

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