An Ω-3 fatty acid desaturase-expressing gene attenuates prostate cancer proliferation by cell cycle regulation

Pan, Jinshun; Zhou, Sujin; Xiang, Rong; Zhao, Z. X.; Liu, Shanshan; Ding, Ning; Gong, Sijia; Yang, Lin; Li, Xiaoxi; Bai, Xu; Li, Fanghong; Zhao, Allan Z.

doi:10.3892/ol.2017.5880

Cited by 7 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous study, ESCs derived from fad3b (has similar functions as Fat-1 [40]) transgenic mice showed a much slower cell cycle with an increased n-3 PUFA content in the cells [41]. In other studies, n-3 PUFAs could also inhibit the proliferation of different kinds of cancer cells by regulating their cell cycle [42][43][44][45]. Therefore, Fat-1 expression cells may also have a lower proliferation rate than Fat-1 silencing cells or cells in wild type sheep.…”

Section: Discussionmentioning

confidence: 94%

Comparative Transcriptome Analysis Provides Insights into the Polyunsaturated Fatty Acid Synthesis Regulation of Fat-1 Transgenic Sheep

Luo

Zheng

Yang

et al. 2020

IJMS

View full text Add to dashboard Cite

Transgenic technology has huge application potential in agriculture and medical fields, such as producing new livestock varieties with new valuable features and xenotransplantation. However, how an exogenous gene affects the host animal’s gene regulation networks and their health status is still poorly understood. In the current study, Fat-1 transgenic sheep were generated, and the tissues from 100-day abnormal (DAF_1) and normal (DAF_2) fetuses, postnatal lambs (DAF_4), transgenic-silencing (DAFG5), and -expressing (DAFG6) skin cells were collected and subjected to transcriptome sequencing, and their gene expression profiles were compared in multiple dimensions. The results were as follows. For DAF_1, its abnormal development was caused by pathogen invasion but not the introduction of the Fat-1 gene. Fat-1 expression down-regulated the genes related to the cell cycle; the NF-κB signaling pathway and the PI3K/Akt signaling pathway were down-regulated, and the PUFAs (polyunsaturated fatty acids) biosynthesis pathway was shifted toward the biosynthesis of high-level n-3 LC-PUFAs (long-chain PUFAs). Four key node genes, FADS2, PPARA, PRKACA, and ACACA, were found to be responsible for the gene expression profile shift from the Fat-1 transgenic 100-day fetus to postnatal lamb, and FADS2 may play a key role in the accumulation of n-3 LC-PUFAs in Fat-1 transgenic sheep muscle. Our study provides new insights into the FUFAs synthesis regulation in Fat-1 transgenic animals.

show abstract

Section: Discussionmentioning

confidence: 94%

Comparative Transcriptome Analysis Provides Insights into the Polyunsaturated Fatty Acid Synthesis Regulation of Fat-1 Transgenic Sheep

Luo

Zheng

Yang

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…In modern electronics, there are many devices that can convert energy from magnetic to electrical energy and vice versa. − The cross-coupling between the magnetic and ferroelectric phases of the materials exhibits a magnetoelectric effect (ME effect). It is possible to control electrical polarization using a magnetic field and, conversely, to manipulate magnetization by varying an electrical field. − The ME effect in composites is a tensor product that results from the cross-interaction of the composite’s constituent phases . The ME effect is not present in the piezoelectric or ferromagnetic phases.…”

Section: Introductionmentioning

confidence: 99%

Strategic Design and Analysis of Energy Storage and ME Applications of Low Temperature Hybrid Microwave Sintered Electroceramic Composites

Thirumalasetty,

Krishnan,

Kota Venkata

et al. 2023

ACS Appl. Electron. Mater.

View full text Add to dashboard Cite

The magnetoelectric particulate (0−3) composites (x) (PbZr 0.52 Ti 0.48 O 3 )-(1 − x) (Y 3 Fe 5 O 12 ) (where, x = 0.25, 0.5, 0.75) are synthesized by the solid-state hybrid microwave sintering technique. Multiferroic bulk ceramic capacitors have attracted immense interest in energy storage devices for pulsed power systems because of their superior temperature resistance and environment-friendliness. Even though significant attempts have been made to create massive magneto electric (ME) bulk ceramics for various applications, it still needs to be practical or scientifically recommended for investigating novel material systems with multiple applications. In this work, coexistence of optimized composition of ferroelectric and ferromagnetic continents is proposed to achieve multiple applications like energy storage and energy conversion (magnetoelectric). Ceramics made of PZT and YIG are chosen to demonstrate multiple applications that are both possible and practical. Encouragingly, a moderate energy storage efficiency of (33%) and good ME of (1.9 mv) are achieved in PZT 0.75 −YIG 0.25 and PZT 0.5 −YIG 0.5 bulk ceramics. Most importantly, the present work provides essential information for designing a series of ME compositions for nextgeneration energy storage and magnetoelectric applications.

show abstract

“…The consumption of certain oils, such as saturated fats and plant-based ω-9 fatty acids primarily composed of oleic acid (OA), has been associated with an increased incidence of PCa (Elkacmi et al, 2016;Allott et al, 2017;Aldaw et al, 2018;Liotti et al, 2018;Wang et al, 2022). On the other hand, fish oil (FO), which is primarily composed of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been shown to reduce the risk of developing PCa (Williams et al, 2011;Bassett et al, 2013;Richman et al, 2013;Pan et al, 2017). The major components of ω-3 PUFAs in FO are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (Hull, 2011).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cells

Jiang,

He,

et al. 2023

Life Sci. Alliance

View full text Add to dashboard Cite

Prostate cancer (PCa) poses a significant health threat to males, and research has shown that fish oil (FO) can impede PCa progression by activating multiple mitochondria-related pathways. Our research is focused on investigating the impact of FO on succinylation, a posttranslational modification that is closely associated with mitochondria in PCa cells. This study employed a mass spectrometry-based approach to investigate succinylation in PCa cells. Bioinformatics analysis of these succinylated proteins identified glutamic–oxaloacetic transaminase 2 (GOT2) protein as a key player in PCa cell proliferation. Immunoprecipitation and RNA interference technologies validated the functional data. Further analyses revealed the significance of GOT2 protein in regulating nucleotide synthesis by providing aspartate, which is critical for the survival and proliferation of PCa cells. Our findings suggest that FO-dependent GOT2 succinylation status has the potential to inhibit building block generation. This study lays a solid foundation for future research into the role of succinylation in various biological processes. This study highlights the potential use of FO as a nutrition supplement for managing and slowing down PCa progression.

show abstract

An Ω-3 fatty acid desaturase-expressing gene attenuates prostate cancer proliferation by cell cycle regulation

Cited by 7 publications

References 37 publications

Comparative Transcriptome Analysis Provides Insights into the Polyunsaturated Fatty Acid Synthesis Regulation of Fat-1 Transgenic Sheep

Comparative Transcriptome Analysis Provides Insights into the Polyunsaturated Fatty Acid Synthesis Regulation of Fat-1 Transgenic Sheep

Strategic Design and Analysis of Energy Storage and ME Applications of Low Temperature Hybrid Microwave Sintered Electroceramic Composites

Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cells

Contact Info

Product

Resources

About