An X-Linked Sex Ratio Distorter in <i>Drosophila simulans</i> That Kills or Incapacitates Both Noncarrier Sperm and Sons

Rice, William R.

doi:10.1534/g3.114.013292

Cited by 4 publications

(2 citation statements)

References 42 publications

(49 reference statements)

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“…However, based on our phylogeny it is most parsimonious that the sensitive lineage (Cluster I) corresponds to a secondary loss of resistance to Paris SR. Consistently, previous work suggested that the Y chromosome of D. sechellia is resistant to the Paris drivers (Tao et al 2007; Rice 2014).…”

Section: Discussionsupporting

confidence: 85%

The evolutionary history ofDrosophila simulansY chromosomes reveals molecular signatures of resistance to sex ratio meiotic drive

Courret

Ogereau

Gilbert

et al. 2022

Preprint

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The recent evolutionary history of the Y chromosome in Drosophila simulans, a worldwide species of Afrotropical origin, is closely linked to that of X-linked meiotic drivers (Paris system). The spread of the Paris drivers in natural populations has elicited the selection of drive resistant Y chromosomes. To infer the evolutionary history of the Y chromosome in relation to the Paris drive, we sequenced 21 iso-Y lines, each carrying a Y chromosome from a different location. Among them, 13 lines carry a Y chromosome that is able to counteract the effect of the drivers. Despite their very different geographical origins, all sensitive Y's are highly similar, suggesting that they share a recent common ancestor. The resistant Y chromosomes are more divergent and segregate in four distinct clusters. The phylogeny of the Y chromosome confirms that the resistant lineage predates the emergence of Paris drive. The ancestry of the resistant lineage is further supported by the examination of Y-linked sequences in the sister species of D. simulans, D. sechellia and D. mauritiana. We also characterized the variation in repeat content among Y chromosomes and identified two simple satellites ((AAACAAT)n and (AATGG)n) associated with resistance. Altogether, the molecular polymorphism allows us to infer the demographic and evolutionary history of the Y chromosome and provides new insights on the genetic basis of resistance.

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Section: Discussionsupporting

confidence: 85%

The evolutionary history ofDrosophila simulansY chromosomes reveals molecular signatures of resistance to sex ratio meiotic drive

Courret

Ogereau

Gilbert

et al. 2022

Preprint

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show abstract

“…[19][20][21][22] Biased sex ratios have also been reported. [23][24][25][26][27][28][29] These exceptions arise despite strong selective pressures that strive to maintain normal segregation 2 and sex ratios 30,31 Based on haploid effects in gametes, one allele is preferentially transmitted to offspring at the expense of other alleles. TRD is usually the property of one sex, driving allelic preference regardless of the genetics of the mating partner.…”

Section: Introductionmentioning

confidence: 99%

Do gametes woo? Evidence for non-random unions at fertilization

Nadeau

2017

Preprint

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A fundamental tenet of inheritance in sexually reproducing organisms such as humans and laboratory mice is that genetic variants combine randomly at fertilization, thereby ensuring a balanced and statistically predictable representation of inherited variants in each generation. This principle is encapsulated in Mendel's First Law. But exceptions are known. With transmission ratio distortion (TRD), particular alleles are preferentially transmitted to offspring without reducing reproductive productivity. Preferential transmission usually occurs in one sex but not both and is not known to require interactions between gametes at fertilization. We recently discovered, in our work in mice and in other reports in the literature, instances where any of 12 mutant genes bias fertilization, with either too many or too few heterozygotes and too few homozygotes, depending on the mutant gene and on dietary conditions. Although such deviations are usually attributed to embryonic lethality of the under-represented genotypes, the evidence is more consistent with genetically-determined preferences for specific combinations of egg and sperm at fertilization that results in genotype bias without embryo loss. These genes and diets could bias fertilization in at least three not mutually exclusive ways. They could trigger a reversal in the order of meiotic divisions during oogenesis so that the genetics of fertilizing sperm elicits preferential chromatid segregation, thereby dictating which allele remains in the egg versus the 2 nd polar body. Bias could also result from genetic-and diet-induced anomalies in polyamine metabolism on which function of haploid gametes normally depends. Finally, secreted and cell-surface factors in female reproductive organs could control access of sperm to eggs based on their genetic content. This unexpected discovery of genetically-biased fertilization in mice could yield insights about the molecular and cellular interactions between sperm and egg at fertilization, with implications for our understanding of inheritance, reproduction, population genetics, and medical genetics. [298 words]All rights reserved. No reuse allowed without permission.(which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/127134 doi: bioRxiv preprint first posted online Apr. 13, 2017; 3 Our understanding of inheritance in sexually reproducing organisms assumes, with good evidence, that the combination of egg and sperm at fertilization is largely independent of their genetic content. This equal transmission of alternative alleles through meiosis in heterozygotes ensures a balanced parental genetic contribution to offspring at each generation. Mendel's First Law captures this principle, which is one of the few that applies generally in biology. Independent segregation and random union of gametes at fertilization are foundations of classical, quantitative, population, evolutionary and me...

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The Evolutionary History of Drosophila simulans Y Chromosomes Reveals Molecular Signatures of Resistance to Sex Ratio Meiotic Drive

Courret

Ogereau

Gilbert

et al. 2023

Molecular Biology and Evolution

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The recent evolutionary history of the Y chromosome in Drosophila simulans, a worldwide species of Afrotropical origin, is closely linked to that of X-linked meiotic drivers (Paris system). The spread of the Paris drivers in natural populations has elicited the selection of drive resistant Y chromosomes. To infer the evolutionary history of the Y chromosome in relation to the Paris drive, we sequenced 21 iso-Y lines, each carrying a Y chromosome from a different location. Among them, 13 lines carry a Y chromosome that is able to counteract the effect of the drivers. Despite their very different geographical origins, all sensitive Y’s are highly similar, suggesting that they share a recent common ancestor. The resistant Y chromosomes are more divergent and segregate in four distinct clusters. The phylogeny of the Y chromosome confirms that the resistant lineage predates the emergence of Paris drive. The ancestry of the resistant lineage is further supported by the examination of Y-linked sequences in the sister species of D. simulans, D. sechellia, and D. mauritiana. We also characterized the variation in repeat content among Y chromosomes and identified multiple simple satellites associated with resistance. Altogether, the molecular polymorphism allows us to infer the demographic and evolutionary history of the Y chromosome and provides new insights on the genetic basis of resistance.

show abstract

An X-Linked Sex Ratio Distorter in Drosophila simulans That Kills or Incapacitates Both Noncarrier Sperm and Sons

Cited by 4 publications

References 42 publications

The evolutionary history ofDrosophila simulansY chromosomes reveals molecular signatures of resistance to sex ratio meiotic drive

The evolutionary history ofDrosophila simulansY chromosomes reveals molecular signatures of resistance to sex ratio meiotic drive

Do gametes woo? Evidence for non-random unions at fertilization

The Evolutionary History of Drosophila simulans Y Chromosomes Reveals Molecular Signatures of Resistance to Sex Ratio Meiotic Drive

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