An Usefulness of<i>In Vitro</i>Interferon Gamma Assay for the Diagnosis of Latent Tuberculosis Infection in Middle- and High-School Students in Jeju-Shi, Korea

Bae, Jong Myon; Kim, Eun Hee; Wang, Ok Bo

doi:10.4046/trd.2010.68.3.155

Tuberc Respir Dis

2010

DOI: 10.4046/trd.2010.68.3.155

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An Usefulness ofIn VitroInterferon Gamma Assay for the Diagnosis of Latent Tuberculosis Infection in Middle- and High-School Students in Jeju-Shi, Korea

Jong Myon Bae

Eun Hee Kim

Ok Bo Wang

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Cited by 2 publications

References 33 publications

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Prevalence and Risk Factors forMycobacterium tuberculosisInfection among Contacts of Pulmonary Tuberculosis Patients

Park

2012

Tuberc Respir Dis

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Background: Detection and treatment of tuberculosis (TB) infection with contact investigation is a key component of TB control program. I evaluated the prevalence and risk factors for TB infection among contacts of recently diagnosed pulmonary TB patients in a tertiary hospital in Korea. Methods: 206 contacts of 90 adult pulmonary TB patients underwent tuberculin skin tests (TST) and chest radiography. The TST results were considered positive with an induration of 10 mm or more, suggesting TB infection. A standardized questionnaire was used to assess risk factors associated with TB infection. Results: TST was positive in 97 of 206 contacts of TB patients (47.1%) and positive rate of TST increased with age. The risk of TB infection was significantly associated with close contact with TB patients (sleeping in the same room) (odd ratio [OR], 4.94; 95% confidence interval [CI], 1.43∼17.00). Conclusion: TB infection rate was higher in the elderly, and the risk of TB infection was significantly increased with close contact of TB patients.

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Prevalence and Risk Factors forMycobacterium tuberculosisInfection among Contacts of Pulmonary Tuberculosis Patients

Park

2012

Tuberc Respir Dis

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Economic Analysis of Latent Tuberculosis Infection Screening Strategies in Korea

Kim¹,

Kang²,

Shin³

et al. 2013

Health Policy and Management

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Background: Although interferon-gamma release assay (IGRA) is now available alternatives to tuberculin skin test (TST) for detection of latent tuberculosis infection (LTBI), the cost of IGRA test is much higher than TST. So economic analysis of LTBI screening strategies have been done in many countries, but there are few reports in Korea. This study examined cost analysis of LTBI screening strategies in Korea. Methods: The economic outcomes were evaluated by five strategies. These were 1) TST alone, 2) IGRA alone, 3) combination of TST and IGRA (TST followed by IGRA) and 4) no testing no prevention, 5) no testing all prevention. Last two strategies were added to compare with three main LTBI screening strategies. Decision analysis model were used to perform economic analysis. A cohort study of Korean Institute of Tuberculosis and the data of published literatures were used to estimate the cost analysis. Results: In a base-case scenario which was assumed that TST specificity was 80%, TST alone was the least expensive strategy. In a alternative scenario which was assumed that TST specificity was 97%, the combination of TST and IGRA was the least expensive strategy. Sensitivity analysis shows that patients adherent rate to LTBI treatment, TST sensitivity, IGRA sensitivity and IGRA specificity did not have a significant impact on the outcomes. Conclusion: In Korea, for the diagnosis of LTBI at the time of child and adolescent, TST alone reduces medical costs compared with IGRA alone or combination of TST and IGRA.

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An Usefulness ofIn VitroInterferon Gamma Assay for the Diagnosis of Latent Tuberculosis Infection in Middle- and High-School Students in Jeju-Shi, Korea

Cited by 2 publications

References 33 publications

Prevalence and Risk Factors forMycobacterium tuberculosisInfection among Contacts of Pulmonary Tuberculosis Patients

Prevalence and Risk Factors forMycobacterium tuberculosisInfection among Contacts of Pulmonary Tuberculosis Patients

Economic Analysis of Latent Tuberculosis Infection Screening Strategies in Korea

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