An updated systematic review on the association between Cd exposure, blood pressure and hypertension

Martins, Airton C.; Lopes, Ana Carolina B. Almeida; Urbano, Mariana Ragassi; Carvalho, Maria de Fátima; Silva, Ana Maria R.; Tinkov, Alexey A.; Aschner, Michael; Mesas, Arthur Eumann; Silbergeld, Ellen K.; Paoliello, Mônica Maria Bastos

doi:10.1016/j.ecoenv.2020.111636

Cited by 41 publications

(24 citation statements)

References 97 publications

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“…Signi cant associations between Cd levels in blood and urine and blood pressures and hypertension were not observed among NHA and non-NHA, which were inconsistent with previous study [52]. However, an updated systematic review on the association between Cd exposure, blood pressure and hypertension demonstrated that these association remains uncertain [7].…”

Section: Discussioncontrasting

confidence: 57%

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Arsenic, Lead, Cadmium, Mercury and Hypertension among Asian Populations in the United States: NHANES 2011-2016

Tang¹,

Zhu²,

Xu³

et al. 2021

Preprint

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Background:Asian Americans have been reported having higher arsenic (As), lead (Pb), cadmium (Cd) and mercury (Hg) levels, comparing with non-Asian Americans. Exposure to these metals/metalloids have been associated with risk of hypertension, however, limited studies have explored the associations of As, Pb, Cd and Hg levels with hypertension among general Asian Americans. This study aimed to investigate the associations of As, Pb, Cd and Hg levels with blood pressure and prevalence of hypertension among Asian Americans who participated in the 2011-2016 National Health and Nutrition and Examination Survey (NHANES).Methods:The study included participants aged 20 years and older with determinations of As, Pb, Cd and Hg in blood (n=7913) and urine (n=3954). These metals levels were measured by inductively coupled plasma mass spectrometry. Systolic (SBP) and diastolic blood pressure (DBP) levels were examined through a standardized protocol. Censored normal regression model and logistic regression model were employed to explore the associations of As, Pb, Cd and Hg levels with blood pressure levels and hypertension respectively, and potential confounders were also adjusted in these regression models.Results:In multivariable-adjusted models, blood Hg levels were associated with increased SBP (tertile 2 vs. tertile 1: β=-0.9 mmHg, 95%CI:-6.1, 4.4; tertile 3 vs. tertile 1: β=5.6, 95%CI: 0.0, 11.2; P trend=0.003), DBP level (tertile 2 vs. tertile 1: β=4.1 mmHg, 95% CI: 0.1, 8.1; tertile 3 vs. tertile 1: β=5.8 mmHg, 95% CI: 1.9, 9.7; P trend=0.003) and prevalence of hypertension (tertile 2 vs. tertile 1: OR=1.2, 95% CI: 0.4, 3.4; tertile 3 vs. tertile 1: OR=2.8, 95% CI: 1.1, 7.3; P trend=0.001) among Asian Americans. The positive associations were also found between blood methyl-Hg level and blood pressure levels and prevalence of hypertension, whereas we did not identify significant associations of As, Pb and Cd levels in blood and urine with blood pressure levels and hypertension among Asian Americans. Conclusions:Highly exposed to Hg level among Asian Americans might associated with increased blood pressure levels and prevalence of hypertension. Further prospective studies with larger sample size should be performed to warrant the results.

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Section: Discussioncontrasting

confidence: 57%

“…Low-level Pb exposure was associated with increase blood pressure and risk of hypertension [5,6]. An updated systematic review and meta-analyses identi ed a positive association between Cd exposure and blood pressure and/or hypertension [7].…”

Section: Introductionmentioning

confidence: 99%

Arsenic, Lead, Cadmium, Mercury and Hypertension among Asian Populations in the United States: NHANES 2011-2016

Tang¹,

Zhu²,

Xu³

et al. 2021

Preprint

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“…For glucose disturbances and T2DM, suggestive associations have been observed [ 156 , 157 ]. Hypertension was examined in three review studies (one systematic review, one systematic review and meta-analysis, and one review article) showing some evidence of association with cadmium exposure [ 157 , 158 , 159 ]. Satarug et al [ 157 ] highlight that women seemed to be more susceptible to adverse blood pressure effects than men.…”

Section: Resultsmentioning

confidence: 99%

Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects

Haverinen

Fernández

Mustieles

et al. 2021

IJERPH

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Increasing prevalence of metabolic syndrome (MetS) is causing a significant health burden among the European population. Current knowledge supports the notion that endocrine-disrupting chemicals (EDCs) interfere with human metabolism and hormonal balance, contributing to the conventionally recognized lifestyle-related MetS risk factors. This review aims to identify epidemiological studies focusing on the association between MetS or its individual components (e.g., obesity, insulin resistance, diabetes, dyslipidemia and hypertension) and eight HBM4EU priority substances (bisphenol A (BPA), per- and polyfluoroalkyl substances (PFASs), phthalates, polycyclic aromatic hydrocarbons (PAHs), pesticides and heavy metals (cadmium, arsenic and mercury)). Thus far, human biomonitoring (HBM) studies have presented evidence supporting the role of EDC exposures on the development of individual MetS components. The strength of the association varies between the components and EDCs. Current evidence on metabolic disturbances and EDCs is still limited and heterogeneous, and mainly represent studies from North America and Asia, highlighting the need for well-conducted and harmonized HBM programmes among the European population. Rigorous and ongoing HBM in combination with health monitoring can help to identify the most concerning EDC exposures, to guide future risk assessment and policy actions.

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“…Since Cd toxicity is dependent on its concentration in the kidneys, its adverse effects are typically not observed in shorter durations. In addition, the health effects of Cd exposure have been reported to be an increased risk of any CVD [26], stroke [27], and hypertension [28]. Results from several experimental studies support the effects of Cd toxicity on cardiovascular disease risk, including endothelial cell death, oxidative stress, smooth muscle cell accumulation, and vascular inflammation [29].…”

Section: Discussionmentioning

confidence: 94%

Trends in Urinary and Blood Cadmium Levels in U.S. Adults with or without Comorbidities, 1999–2018

Yang

2022

Nutrients

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Although cadmium (Cd) exposure has been declining in the United States (U.S.) over the years, the level of exposure for people with pre-existing comorbidities is unclear. This study characterized the trends of blood Cd levels (bCd) (n = 44,498) and urinary Cd levels (uCd) (n = 15,107) by pre-existing comorbidities among adults participating in the U.S. National Health and Nutrition Examination Survey. We calculated age- and sex-standardized annual geometric mean (GM) levels, and used aJoinpoint regression model to examine the trends over time. The GM levels of bCd declined from 1999–2000 to 2017–2018 survey cycles (from 0.49 to 0.33 μg/L), while women and current smokers had higher levels. Participants with comorbidities had higher bCd and declined over time: cardiovascular disease (CVD) (0.50 to 0.42 μg/L), hypertension (0.49 to 0.35 μg/L), chronic kidney disease (CKD) (0.54 to 0.37 μg), and cancer (0.57 to 0.38 μg) versus those without these comorbidities. We observed the similar pattern of changes for uCd and participants with CVD, CKD, and cancer had higher levels. To conclude, the trend in urinary and blood Cd levels in U.S adults decreased in the past 20 years, and the levels varied by sex, smoking status, and comorbidities.

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An updated systematic review on the association between Cd exposure, blood pressure and hypertension

Cited by 41 publications

References 97 publications

Arsenic, Lead, Cadmium, Mercury and Hypertension among Asian Populations in the United States: NHANES 2011-2016

Arsenic, Lead, Cadmium, Mercury and Hypertension among Asian Populations in the United States: NHANES 2011-2016

Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects

Trends in Urinary and Blood Cadmium Levels in U.S. Adults with or without Comorbidities, 1999–2018

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