An updated systematic review and meta‐analysis on the association between <i><scp>H</scp>elicobacter pylori</i> infection and iron deficiency anemia

Hudak, Lauren A.; Jaraisy, Ameen; Haj, Saeda; Muhsen, Khitam

doi:10.1111/hel.12330

Cited by 139 publications

(155 citation statements)

References 83 publications

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“…(iv) A double intoxication then occurs, justifying numerous extradigestive pathologies described in Table 2. (v) This statement is in perfect harmony with recent literature which reports more and more extra-digestive pathologies linked to Helicobacter pylori [23,28,[35][36][37][38][39][40][41].…”

Section: Drc Helicobacter Pylori Phenomenonsupporting

confidence: 84%

Meanders of an Atypical Research Work on Helicobacter pylori in the Democratic Republic of Congo: Influence of HIV and other Factors and Study of some Interesting Cases

NdelodiPhanzu¹,

Malolo²,

Matondo³

et al. 2018

J Pharmacogenomics Pharmacoproteomics

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During the 3 rd Euro case reports in Valencia, Spain, a strange medical case taking place in the DRC has been presented. Indeed, while the Congolese population is, until now, convinced of the existence of massive criminal poisonings, throughout the national area, originating from the East region of the country, we incredibly observed and demonstrated that actually, the phenomenon is a silent, surprising and unexpected Helicobacter pylori epidemic with numerous extra-digestive pathologies. The present subject will deal with picturesque meanders by which our research work passed, lengthening it to more than twenty years before getting appropriate results. The presentation will start by a brief summary of the DRC Helicobacter pylori phenomenon described in Valencia and hypothesis raised for better knowledge of Helicobacter pylori infection, at the international level. In a second time, it will focus on the influence and consequences of some followed factors in our study: HIV infection, political situation in DRC, lack of equipment and financial means, population ignorance, traditional practitioners' cupidity, deficiency of south-North collaboration, and so on. Afterwards, two interesting incredible extra-digestive DRC Helicobacter pylori cases observed in our study will be discussed. Finally a brief conclusion will present some useful propositions drawn from the experience of this DRC Helicobacter pylori research work.

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Section: Drc Helicobacter Pylori Phenomenonsupporting

confidence: 84%

Meanders of an Atypical Research Work on Helicobacter pylori in the Democratic Republic of Congo: Influence of HIV and other Factors and Study of some Interesting Cases

NdelodiPhanzu¹,

Malolo²,

Matondo³

et al. 2018

J Pharmacogenomics Pharmacoproteomics

View full text Add to dashboard Cite

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“…10 The first is that infection is a risk factor for ulcers, especially gastric. Second, infection results in achlorhydria, which results in impaired iron absorption, leading to inability to convert ferric to ferrous iron.…”

Section: Epidemiology and Etiologiesmentioning

confidence: 99%

Iron Deficiency Anemia

DeLoughery

2017

Medical Clinics of North America

174

120

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“…North African countries do not experience malaria and are less exposed to parasites [25], but they experience a high and possibly growing prevalence of Helicobacter pylori , especially in Algeria, but also in Egypt and Morocco [26]. A recent meta-analysis concluded on a plausible link between Helicobacter pylori infection and ID [27] but studies that have measured iron absorption in individuals with Helicobacter pylori infection have produced mixed results [28,29,30,31], and the role of Helicobacter pylori in the etiology of ID in Africa remains uncertain.…”

Section: Iron Deficiency In Africa: Prevalence Causes and Diagnosmentioning

confidence: 99%

Iron for Africa—Report of an Expert Workshop

et al. 2017

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Scientific experts from nine countries gathered to share their views and experience around iron interventions in Africa. Inappropriate eating habits, infections and parasitism are responsible for significant prevalence of iron deficiency, but reliable and country-comparable prevalence estimates are lacking: improvements in biomarkers and cut-offs values adapted to context of use are needed. Benefits of iron interventions on growth and development are indisputable and outweigh risks, which exist in populations with a high infectious burden. Indeed, pathogen growth may increase with enhanced available iron, calling for caution and preventive measures where malaria or other infections are prevalent. Most African countries programmatically fortify flour and supplement pregnant women, while iron deficiency in young children is rather addressed at individual level. Coverage and efficacy could improve through increased access for target populations, raised awareness and lower cost. More bioavailable iron forms, helping to decrease iron dose, or prebiotics, which both may lower risk of infections are attractive opportunities for Africa. Fortifying specific food products could be a relevant route, adapted to local context and needs of population groups while providing education and training. More globally, partnerships involving various stakeholders are encouraged, that could tackle all aspects of the issue.

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An updated systematic review and meta‐analysis on the association between Helicobacter pylori infection and iron deficiency anemia

Abstract: Current evidence indicates increased likelihood of depleted iron stores in relation to H. pylori infection. H. pylori eradication therapy, added to iron therapy, might be beneficial in increasing ferritin and hemoglobin levels.

Cited by 139 publications

References 83 publications

Meanders of an Atypical Research Work on Helicobacter pylori in the Democratic Republic of Congo: Influence of HIV and other Factors and Study of some Interesting Cases

Meanders of an Atypical Research Work on Helicobacter pylori in the Democratic Republic of Congo: Influence of HIV and other Factors and Study of some Interesting Cases

Iron Deficiency Anemia

Iron for Africa—Report of an Expert Workshop

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