An updated review on particle separation in passive microfluidic devices

Bayareh, Morteza

doi:10.1016/j.cep.2020.107984

Cited by 83 publications

(25 citation statements)

References 114 publications

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“…The performance of microfluidic separation is evaluated according to the separation time, separation efficiency, throughput rate, and clogging filtration. According to separation approaches, separation techniques can be divided into passive and active methods [ 64 ]. The present paper focuses solely on passive separation/sorting approaches because they are easier to implement and thus can find more applications for public health, especially in developing countries or regions where people have limited access to costly apparatuses to energize the active separation approaches.…”

Section: Microfluidic Separation Methodsmentioning

confidence: 99%

Public-Health-Driven Microfluidic Technologies: From Separation to Detection

Zhang

Wang

et al. 2021

Micromachines

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Separation and detection are ubiquitous in our daily life and they are two of the most important steps toward practical biomedical diagnostics and industrial applications. A deep understanding of working principles and examples of separation and detection enables a plethora of applications from blood test and air/water quality monitoring to food safety and biosecurity; none of which are irrelevant to public health. Microfluidics can separate and detect various particles/aerosols as well as cells/viruses in a cost-effective and easy-to-operate manner. There are a number of papers reviewing microfluidic separation and detection, but to the best of our knowledge, the two topics are normally reviewed separately. In fact, these two themes are closely related with each other from the perspectives of public health: understanding separation or sorting technique will lead to the development of new detection methods, thereby providing new paths to guide the separation routes. Therefore, the purpose of this review paper is two-fold: reporting the latest developments in the application of microfluidics for separation and outlining the emerging research in microfluidic detection. The dominating microfluidics-based passive separation methods and detection methods are discussed, along with the future perspectives and challenges being discussed. Our work inspires novel development of separation and detection methods for the benefits of public health.

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Section: Microfluidic Separation Methodsmentioning

confidence: 99%

Public-Health-Driven Microfluidic Technologies: From Separation to Detection

Zhang

Wang

et al. 2021

Micromachines

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“…The main challenge of these devices is related to the design of effective fluid manipulation techniques having a large variety of biomolecules (e.g., bacteria, cells, etc., vary in size from ≈1 to 30 µm) and different suspending mediums (blood, cells, sputum, etc.). Recent research has shown, that there are two main particle manipulation techniques widely discussed—active (e.g., acoustophoresis) [ 3 , 5 ] and passive (e.g., internal microfluidics) [ 6 , 7 ], both of them are used in diagnostic and medical applications. Passive techniques are based on hydrodynamic particle manipulation by tuning geometry and fluid; active ones—by acoustic manipulation.…”

Section: Introductionmentioning

confidence: 99%

Biologically Compatible Lead-Free Piezoelectric Composite for Acoustophoresis Based Particle Manipulation Techniques

Janušas

Urbaite

Palevičius

et al. 2021

Sensors

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This research paper is concentrated on the design of biologically compatible lead-free piezoelectric composites which may eventually replace traditional lead zirconium titanate (PZT) in micromechanical fluidics, the predominantly used ferroelectric material today. Thus, a lead-free barium–calcium zirconate titanate (BCZT) composite was synthesized, its crystalline structure and size, surface morphology, chemical, and piezoelectric properties were analyzed, together with the investigations done in variation of composite thin film thickness and its effect on the element properties. Four elements with different thicknesses of BCZT layers were fabricated and investigated in order to design a functional acoustophoresis micromechanical fluidic element, based on bulk acoustic generation for particle control technologies. Main methods used in this research were as follows: FTIR and XRD for evaluation of chemical and phase composition; SEM—for surface morphology; wettability measurements were used for surface free energy evaluation; a laser triangular sensing system—for evaluation of piezoelectric properties. XRD results allowed calculating the average crystallite size, which was 65.68 Å3 confirming the formation of BCZT nanoparticles. SEM micrographs results showed that BCZT thin films have some porosities on the surface with grain size ranging from 0.2 to 7.2 µm. Measurements of wettability showed that thin film surfaces are partially wetting and hydrophilic, with high degree of wettability and strong solid/liquid interactions for liquids. The critical surface tension was calculated in the range from 20.05 to 27.20 mN/m. Finally, investigations of piezoelectric properties showed significant results of lead-free piezoelectric composite, i.e., under 5 N force impulse thin films generated from 76 mV up to 782 mV voltages. Moreover, an experimental analysis showed that a designed lead-free BCZT element creates bulk acoustic waves and allows manipulating bio particles in this fluidic system.

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“…The methods proposed and developed for the manipulation of particles in microfluidic systems can be grouped as active and passive methods determined according to the presence of external force fields integrated into the system [64][65][66][67]. Passive methods do not use external forces to control the movement of particles, instead they merely depend on the channel geometry, and the interactions between particles, fluid flow, and microchannel topology [68][69][70]. Although passive manipulation methods can be performed with simpler structures and allow higher flow rates, their application is limited due to their dependence on fixed microchannel design and geometry [66,67].…”

Section: Introductionmentioning

confidence: 99%

“…Although passive manipulation methods can be performed with simpler structures and allow higher flow rates, their application is limited due to their dependence on fixed microchannel design and geometry [66,67]. These methods are more preferred when input energy is critical [64,70]. In active methods, different forms of fields are employed to generate the external force required for particle manipulation.…”

Section: Introductionmentioning

confidence: 99%

A Prominent Cell Manipulation Technique in BioMEMS: Dielectrophoresis

2020

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BioMEMS, the biological and biomedical applications of micro-electro-mechanical systems (MEMS), has attracted considerable attention in recent years and has found widespread applications in disease detection, advanced diagnosis, therapy, drug delivery, implantable devices, and tissue engineering. One of the most essential and leading goals of the BioMEMS and biosensor technologies is to develop point-of-care (POC) testing systems to perform rapid prognostic or diagnostic tests at a patient site with high accuracy. Manipulation of particles in the analyte of interest is a vital task for POC and biosensor platforms. Dielectrophoresis (DEP), the induced movement of particles in a non-uniform electrical field due to polarization effects, is an accurate, fast, low-cost, and marker-free manipulation technique. It has been indicated as a promising method to characterize, isolate, transport, and trap various particles. The aim of this review is to provide fundamental theory and principles of DEP technique, to explain its importance for the BioMEMS and biosensor fields with detailed references to readers, and to identify and exemplify the application areas in biosensors and POC devices. Finally, the challenges faced in DEP-based systems and the future prospects are discussed.

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An updated review on particle separation in passive microfluidic devices

Cited by 83 publications

References 114 publications

Public-Health-Driven Microfluidic Technologies: From Separation to Detection

Public-Health-Driven Microfluidic Technologies: From Separation to Detection

Biologically Compatible Lead-Free Piezoelectric Composite for Acoustophoresis Based Particle Manipulation Techniques

A Prominent Cell Manipulation Technique in BioMEMS: Dielectrophoresis

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