An Updated Review on Modified Release Tablets

Gujral, Gaurav; Kapoor, Devesh; Jaimini, Manish

doi:10.22270/jddt.v8i4.1722

Cited by 8 publications

(12 citation statements)

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“…There are numerous methods for altering the release profile of tablets to minimize side effects while enhancing the efficiency of the treatment and patient compliance. The osmotic pump-controlled release technique is a popular choice as it ensures prolonged effect and consistent blood concentration [ 93 , 94 ]. With altering the size of the drug release hole of osmotic tablets, the release kinetics can be significantly altered, thus the size must be controlled.…”

Section: Image Analysis Of Pharmaceutical Dosage Formsmentioning

confidence: 99%

Image Analysis: A Versatile Tool in the Manufacturing and Quality Control of Pharmaceutical Dosage Forms

et al. 2021

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In pharmaceutical sciences, visual inspection is one of the oldest methods used for description in pharmacopeias and is still an important part of the characterization and qualification of active ingredients, excipients, and dosage forms. With the development of technology, it is now also possible to take images of various pharmaceutical dosage forms with different imaging methods in a size range that is hardly visible or completely invisible to the human eye. By analyzing high-quality designs, physicochemical processes can be understood, and the results can be used even in the optimization of the composition of the dosage form and in the development of its production. The present study aims to show some of the countless ways image analysis can be used in the manufacturing and quality assessment of different dosage forms. This summary also includes measurements and an evaluation of, amongst others, a less studied dosage form, medicated foams.

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Section: Image Analysis Of Pharmaceutical Dosage Formsmentioning

confidence: 99%

Image Analysis: A Versatile Tool in the Manufacturing and Quality Control of Pharmaceutical Dosage Forms

et al. 2021

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“…Six tablets were selected at random from each batch, and the mean; standard deviation values were calculated The thickness of the tablet is important in producing tablet identical in appearance. Thickness can vary with no change in weight because of the difference in density of the powders 8,9 .…”

Section: Evaluation Of Tabletsmentioning

confidence: 99%

“…Six tablets from each batch were selected and evaluated, and the average value with standard deviation was recorded. The mean ± standard deviation values of hardness were calculated 8,9 .…”

Section: Evaluation Of Tabletsmentioning

confidence: 99%

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2021

IJPSR

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The present study was to develop and evaluate antiulcer polyherbal tablet as designing of oral herbal formulation. The methanolic extracts of Abrus precatorius (MEAP) and Cordia wallichi (MECW) leaves were used in different concentrations in the formulations. Materials and Method: The current exploration was to design a gastro-retentive drug delivery system of MEAP and MECW using swelling polymer through the wet granulation method. All the formulations were evaluated for weight variation, hardness, friability, drug content, and in-vitro dissolution. In this gastro-retentive dosage form using hydroxypropyl methylcellulose-K 4 M was prepared to develop sustain release tablets, which could remain in the stomach for longer periods of time, delivering the drug to the site of action. Results: Pre and Post-compression parameters of all the formulations were within the Pharmacopoeial limits, and in-vitro drug release of F8 formulation was found to be 98.29% in 12 h. Conclusion: Dissolution studies of the composition, it was concluded that the formulation F8, which is containing 200 mg of polyherbal extracts, 140 mg of HPMC-K 4 M, 85 mg of MCC, 65 mg of sodium bicarbonate, 5 mg of magnesium stearate, and 5 mg of Talc is the best formulation. F8 possessed a quick buoyancy lag time of 34 s and a maximum total floating time of 12 h. As the consequence of this study, it may accomplish that the floating tablets using HPMC-K 4 M are a hydrophilic polymer that increases the gross register tonnage of the dissolution fluid to deliver the drug in a sustained manner.

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“…Clinical advantages of such formulation includes reduction in, frequency of drug administration, drug toxicity, drug fluctuation in blood, total drug usage, drug accumulation with chronic therapy, thus is economical to the health care providers and patients, improves patient compliance and often times eliminates the need for night dosing [11]. Commercial advantage includes, patent extension, product life-cycle extension, market expansion and product differentiation while disadvantages include, higher cost per unit dose, delayed onset of action, increase potential for first pass metabolism, possibility of less accurate dose adjustments in some cases, poor in vivo and in vitro correlation, possibility of dose dumping especially in the case of poor formulation strategy [12]. Sustained release system for oral solid formulations is, based on dissolution, diffusion or a combination of both mechanisms in the control of drug release.…”

Section: Tabletsmentioning

confidence: 99%

In Vitro Assay and Dissolution Study of Diclofenac Sodium Tablets Marketed In Port Harcourt, South – South Nigeria

2021

JSTR

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The aim of this study is to determine the potency of Diclofenac sodium tablet available in Port Harcourt metropolis, south-south Nigeria. Diclofenac Sodium is a potent Non-Steroidal Anti-Inflammatory Drug (NSAID) commonly used as an Over the Counter (OTC) drug. Potency determination was performed to evaluate and authenticate whether the marketed samples complies with the declared specification. In vitro dissolution study was, performed to verify the potency of the drug and its relative bioavailability. Hardness was checked to verify whether it interferes with the dissolution, which might ultimately affect the drug bioavailability. In this present study, a simple, cost effective, and spectrophotometric method for the potency determination of marketed diclofenac sodium tablets is used. Six samples were randomly collected from the market and coded as A, B, C, D, E and F, and the potency determined are 80%, 98.7%, 126.9%, 99.6%, 109.2% and 91.4% respectively. Hardness and in vitro dissolution of the six brands of diclofenac sodium tablet were studied and reported. After 1 h dissolution release of samples A, B, C, D, E, and F are 135%, 30%, 70%, 122%, 38%, and 40% respectively. The results obtained from the study signified, that not all the samples analyzed complied with the BP and USP standards or requirements.

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An Updated Review on Modified Release Tablets

Cited by 8 publications

References 0 publications

Image Analysis: A Versatile Tool in the Manufacturing and Quality Control of Pharmaceutical Dosage Forms

Image Analysis: A Versatile Tool in the Manufacturing and Quality Control of Pharmaceutical Dosage Forms

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In Vitro Assay and Dissolution Study of Diclofenac Sodium Tablets Marketed In Port Harcourt, South – South Nigeria

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