An updated review on application of 3D printing in fabricating pharmaceutical dosage forms

Parhi, Rabinarayan; Jena, Goutam Kumar

doi:10.1007/s13346-021-01074-6

Cited by 15 publications

(13 citation statements)

References 201 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The main conclusions of the obtained results are as follows: i) NaCl lowers the sol–gel transition temperature for heating (Figure 1A) and gel–sol transition for cooling (Figure 1B), ii) the difference in the transition temperature for the dosimeter with and without NaCl is 2.5 °C (0 Gy; Table 2), iii) the initial phase of gel–sol conversion during cooling begins at about 17 °C for the dosimeter without NaCl, and at about 14 °C for the dosimeter with NaCl; this means that LCV‐Pluronic F‐127 with NaCl is more resistant to dissolution during cooling, iv) the maximal heat flow for cooling is at 10 and 7.5 °C, for the dosimeter without and with NaCl, respectively, which again denotes better thermal properties of the dosimeter with NaCl at lower temperatures – the goal of this part of study was achieved, v) T c increases slightly with absorbed dose for the dosimeter without NaCl; this observation is somewhat analogous to that discussed elsewhere, [ 61 ] and vi) no significant transition was observed above 40 to 80 °C but for that hardly visible (very low Δ H c ) at about 56 °C (not shown here) which seems to be related to the loss of the physical form at higher temperatures, as previously reported. [ 84–86 ] In consequence, it can be concluded that the transportation temperature of the dosimeter with NaCl ranges from 14 °C to at least 40 °C. This is a satisfactory improvement over the dosimeter without NaCl, especially for the lower temperature.…”

Section: Resultsmentioning

confidence: 99%

First Combined, Double‐Density LCV‐Pluronic F‐127 Radiochromic Dosimeter Mimicking Lungs and Muscles

Kozicki

Bartosiak

Maras

et al. 2023

Adv Materials Technologies

View full text Add to dashboard Cite

3D chemical dosimetry of radiotherapy is an interdisciplinary research related to medical physics, polymer and radiation chemistry, photochemistry, organic chemistry, computer science, oncology, materials engineering, and automation technology. It consists of a 3D high resolution tissue equivalent dosimeter, high resolution 3D reading, and software packages for fast processing of 3D measurement data. Research on 3D radiotherapy chemical dosimetry has been going on for almost forty years, starting with the first proposal of a 3D dosimeter -Fricke dosimetric solution in a physical gel matrix with magnetic resonance imaging (MRI) reading to record the spatial dose distribution. [1] Further research concerned both Fricke-gel dosimeters and other systems, such as polymer gel dosimeters, radiochromic gel and plastic dosimeters, and flexible dosimeters. Many dosimetric compositions have been proposed. As a general rule, each new 3D dosimeter has a specific acronym, usually derived from its components. Examples of 3D polymer gel dosimeters are as follows (the acronyms are associated with example references): BANG, [16] PAG, [17] PAGAT, [18] nMAG, nPAG, [19] MAGIC, [17,20] MAGIC-f, [21] NIPAM, [22,23] VIPAR, [24] VIP (VIPAR nd ), [25] VIC, [26] VIC-T, [26] VIP3-Pluronic F-127, [27,28] PAGAT2-Pluronic F-127, [29] PAB-IG nx , [14,30,31] NHMAGAT, [32] MAGADIT, [33] NMPAGAT. [34] Examples of 3D radiochromic dosimeters are as follows: PVA-GTA-XO-Fricke, [35,36] PVA-GTA-MTB-Fricke, [37] Fricke-XOgelatine, [38] Fricke-XO-Pluronic F-127, [10,13,39] TTC-Pluronic F-127, [40] NBT-Pluronic F-127, [41,42] KI-PVA, [43] KI-Pluronic F-127, [12] LCV-gelatine; [44] and 3D plastic radiochromic dosimeter: PRESAGE. [3,45,46] 3D flexible dosimeters have also been proposed: LMG-silicone, [47,48] FlexyDos3D, [49] as well as 3D lung-mimicking dosimeters: PAGAT-2-Pluronic F-127 foam, [11] foam based on methacrylic acid-gelatine infused with sodium dodecyl sulphate surfactant, [50] and methacrylic acid-gelatine gel with expanded polystyrene spheres. [51] It should be mentioned that alternative 3D reading techniques to MRI were also investigated, including computed tomography (CT), [22,23,52] ultrasonography, [53][54][55] and optical computed tomography (optical CT). [56,57] It has been shown that 3D dosimetry data This work reports on a new type of combined radiochromic ionizing radiation dosimeter for radiotherapy. The LCV-Pluronic F-127 serves for this purpose, which is a leuco crystal violet embedded in a physical hydrogel matrix of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic F-127) with additives. This dosimeter responds to ionizing radiation by developing a blue color with an intensity related to the radiation dose. The LCV-Pluronic F-127 dosimeter is improved for lower temperature stability by adding sodium chloride (NaCl). Subsequently, a method for manufacturing the LCV-Pluronic F-127 lung mimicking dosimeter is proposed. Next, the LCV-Pluronic F-127 3D composite dosimeter is elaborated, which cont...

show abstract

Section: Resultsmentioning

confidence: 99%

First Combined, Double‐Density LCV‐Pluronic F‐127 Radiochromic Dosimeter Mimicking Lungs and Muscles

Kozicki

Bartosiak

Maras

et al. 2023

Adv Materials Technologies

View full text Add to dashboard Cite

show abstract

“…Examples of 3D printed polymers for s‐CAIS templates include resins and thermoplastics 12 . These can also be used for applications such as dental models, denture bases, interim restorations, bleaching trays, and occlusal splints 13–18 …”

Section: Resultsmentioning

confidence: 99%

“…12 These can also be used for applications such as dental models, denture bases, interim restorations, bleaching trays, and occlusal splints. [13][14][15][16][17][18] One of the main issues with resin-based 3D printed materials surrounds biocompatibility. [19][20][21] Most resins used for SLA can be potentially toxic and nonbiocompatible.…”

Section: Resultsmentioning

confidence: 99%

Additively Manufactured Surgical Implant Guides: A Review

Elliott

Hamilton

Griseto

et al. 2022

Journal of Prosthodontics

View full text Add to dashboard Cite

Static computer assisted implant surgery (s-CAIS) is an integral part of the digital workflow in implant dentistry and provides the link between the virtual planning environment and surgical field. The accuracy of s-CAIS is influenced by many cumulative factors including the fit of the template which is related to the manufacturing process. This critical review provides an overview of the current research on additively manufactured surgical implant guides.

show abstract

“…The 3D printing drug has been developed using melt extrusion deposition (MED) to treat rheumatoid arthritis. In parallel, recent publications in the field of pharmaceutical sciences using other methods of 3D printing such as fused deposition modeling (FDM) have increased 19–23 . For example, FDM technique has been applied to fabricate 3D printed versions of Acetaminophen, Prednisolone, Aspirin, Captopril, Nifedipine, and other pills 13,24–28 …”

Section: Introductionmentioning

confidence: 99%

“…In parallel, recent publications in the field of pharmaceutical sciences using other methods of 3D printing such as fused deposition modeling (FDM) have increased. [19][20][21][22][23] For example, FDM technique has been applied to fabricate 3D printed versions of Acetaminophen, Prednisolone, Aspirin, Captopril, Nifedipine, and other pills. 13,[24][25][26][27][28] It is noteworthy that additive manufacturing has recently appeared as the novel approach to overcome the small number of tailored tablets.…”

mentioning

confidence: 99%

Facile fabrication of an extended‐release tablet of Ticagrelor using three dimensional printing technology

Rastpeiman,

Panahi,

Akrami

et al. 2023

J Biomedical Materials Res

View full text Add to dashboard Cite

The objective of the study was to fabricate tailored extended‐release tablets of blood thinner Ticagrelor as once‐daily dosing using additive manufacturing for better compliance in heart failure therapy. The solid work design of the tablet was printed using hot melt extrusion (HME) based 3D printing by optimized mixture of Eudragit RS‐100, plasticizer and drug for producing extrudable and printable filaments. FTIR and TGA results showed no covalent interaction among ingredients and no decomposition during HME process, respectively. Friability, weight variation, assay and content uniformity tests met USP requirements, while the mean hardness of the tablets was calculated in a value between 40 and 50 kg. According to DSC and XRD results, the crystallinity state of the Ticagrelor was converted to an amorphous one in the tablet matrix. Smooth surfaces with multiple deposited layers were observed using SEM. In comparison, the maximum Ticagrelor release of 100% after 120 min from Brilinta® tablets was decreased to 97% in 400 min from the 3D tablet at infill of 90%. Korsmeyer‐Peppas kinetic model showed the drug release mechanism is affected by diffusion and swelling. In general, fabrication of the extended‐release 3D printed tablet of Ticagrelor using HME‐based‐additive manufacturing has the potential to provide specific doses with tailored kinetic release for personalized medicine, improving adherence at point‐of‐care.

show abstract

An updated review on application of 3D printing in fabricating pharmaceutical dosage forms

Cited by 15 publications

References 201 publications

First Combined, Double‐Density LCV‐Pluronic F‐127 Radiochromic Dosimeter Mimicking Lungs and Muscles

First Combined, Double‐Density LCV‐Pluronic F‐127 Radiochromic Dosimeter Mimicking Lungs and Muscles

Additively Manufactured Surgical Implant Guides: A Review

Facile fabrication of an extended‐release tablet of Ticagrelor using three dimensional printing technology

Contact Info

Product

Resources

About