An updated review of pediatric autoimmune neuropsychiatric disorders associated with Streptococcus/pediatric acute-onset neuropsychiatric syndrome, also known as idiopathic autoimmune encephalitis: What the allergist should know

Hardin, Hannah; Shao, Wenhai; Bernstein, Jonathan A.

doi:10.1016/j.anai.2023.08.022

Cited by 1 publication

(7 citation statements)

References 48 publications

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“…However, the evidence to treat PANS with SSRI is limited to the clinical experience, with no controlled trial done yet [ 14 ]. As children with PANDAS may be susceptible to the side effects of serotonin reuptake inhibitors and other medications, “starting low and going slow” is essential when administering these drugs [ 3 ]. SSRI may help restrict eating and/or fluid if it is related to OCD.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The incidence and prevalence of PANDAS are unknown, although they are considered rare [ 2 , 3 ]. According to the PANDAS network, it has been postulated that the prevalence of this disorder would be higher than previously acknowledged, potentially impacting up to 1 in 200 children [ 3 ]. In 2021, the Pediatric Acute-Onset Neuropsychiatric Syndrome Advisory Council in Texas released a report with data concerning age and gender demographics [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…According to the PANDAS network, it has been postulated that the prevalence of this disorder would be higher than previously acknowledged, potentially impacting up to 1 in 200 children [ 3 ]. In 2021, the Pediatric Acute-Onset Neuropsychiatric Syndrome Advisory Council in Texas released a report with data concerning age and gender demographics [ 3 ]. According to the findings, most children diagnosed with PANS are often observed between the age range of 1–13 years.…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, over 60% of diagnoses occur between the ages of 4 and 9 years, with the highest frequency of diagnosis observed at roughly 6.5 years of age. The male population exceeds the female population by a ratio of around 2 to 1 [ 3 ]. Furthermore, it was reported that there is variability in the prevalence of PANS among patients with different disorders.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Pediatric Autoimmune Neuropsychiatric Disorder Linked to Streptococcal Infections

Alqifari,

Maxwell

2023

Case Reports in Psychiatry

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Pediatric acute-onset neuropsychiatric syndrome (PANS) is a clinical condition with abrupt onset of obsessive–compulsive symptoms and/or severe eating restrictions and at least two concomitant cognitive, behavioral, or neurological symptoms. Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) is a subtype of PANS with a controversial diagnosis. A case of a 12-year-old girl with severe eating restriction, obsessive–compulsive symptoms, anxiety, and neurological symptoms who initially was diagnosed with obsessive–compulsive disorder is presented. Published reports were reviewed for the evidence of diagnosis and treatment options of PANS/PANDAS. Studies show controversy regarding diagnosis. Moreover, study reports showed limited evidence for the treatment options. Selective serotonin reuptake inhibitors and psychotherapy are considered the main treatment with prompt infection treatment in the case of PANDAS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%