An Updated Overview of Herpes Simplex Virus-1 Infection: Insights from Origin to Mitigation Measures

Moin, Abu Tayab; Chowdhury, Mohammad Al-baruni; Riana, Sumaiya Hafiz; Ullah, Md. Asad; Araf, Yusha; Shohael, Abdullah Mohammad

doi:10.29333/ejgm/10869

Cited by 4 publications

(5 citation statements)

References 139 publications

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“…In addition, 150 participants were seropositive even though no recurrent infection was reported on them. Recurrent of HSV1 from latent infection was reported by many researchers (49)(50)(51).…”

Section: Discussionmentioning

confidence: 90%

Seroprevalence of HSV1 among Taiz University lecturers, Officers and students

Moatasem Abdul Noor Ghanm,

Nada Jazem Al Qabati,

Heyam Jaml Abdurrahman Sultan

et al. 2023

World J. Adv. Res. Rev.

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HSV1 is a herpesvirus that infect human and latent in the body. Recently infection with HSV1 lead to genital infection. This study aimed to determine the seroprevalence of HSV1 IgG among Taiz university lecturers, officers and students. Briefly, 5ml venous blood was collected from 180 participants in this study. Titer of HSV1 was determined by specific ELISA kit. Almost 91.1% (164/180) were seropositive to HSV1. Regarding to gender 91.93% of males and 89.28% of females were seropositive to HSV1. The highest seropositive 100% among 46-55 and 56-65 years old. Lower HSV1 seropositive among lecturers compared with officers and students. Lower infection was observed among members from faculty of Education, Art and Faculty of engineering and Information Technology. Almost infection was same between members from urban and rural regions. Among all people, 85.71% suffered from HSV1 reinfection. This study showed high seroprevalence of HSV1 among University members due to socioeconomic status and poor hygiene in Yemen as results from war and economic problems that country pass through. Improve hygiene, socioeconomic status and education about viral diseases may be contribute to decrease HSV1 infection in Yemen.

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Section: Discussionmentioning

confidence: 90%

Seroprevalence of HSV1 among Taiz University lecturers, Officers and students

Moatasem Abdul Noor Ghanm,

Nada Jazem Al Qabati,

Heyam Jaml Abdurrahman Sultan

et al. 2023

World J. Adv. Res. Rev.

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show abstract

“…10,11 Recent statistical evidence underscores a notable rise in HSV-1 infections among individuals aged 30-50, alongside the emergence of cases in newborns. 12 It should be emphasised that specific individuals carrying the HSV infection might exhibit no symptoms, yet they remain capable of transmitting the virus to others. 13 Infections caused by these viruses frequently remain latent and devoid of signs, marked by recurrent reactivations and sporadic symptomatic occurrences.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, prompt and accurate viral detection through reliable assays followed by immediate intervention is key to preventing future catastrophic outbreaks. 12 The development of vaccines targeting HSV-1 and HSV-2 is a central focus of ongoing global endeavours. 21,22 Neuroinflammation denotes an inflammatory reaction occurring within the brain and spinal cord, orchestrated by the production of cytokines, chemokines, reactive oxygen species (ROS), and secondary messengers such as nitric oxide and prostaglandins.…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, the manifestations of genital herpes involve painful blisters or lesions around the genital region, rectum, and buttocks, accompanied by sensations of itching or burning and flu‐like symptoms like fever and enlarged glands 10,11 . Recent statistical evidence underscores a notable rise in HSV‐1 infections among individuals aged 30–50, alongside the emergence of cases in newborns 12 . It should be emphasised that specific individuals carrying the HSV infection might exhibit no symptoms, yet they remain capable of transmitting the virus to others 13 .…”

Section: Introductionmentioning

confidence: 99%

“…Developing effective vaccines and potent drugs to eliminate viruses from infected individuals is imperative to avert future viral epidemics or pandemics. Thus, prompt and accurate viral detection through reliable assays followed by immediate intervention is key to preventing future catastrophic outbreaks 12 . The development of vaccines targeting HSV‐1 and HSV‐2 is a central focus of ongoing global endeavours 21,22 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries

Hussain,

Gupta,

Samuel

et al. 2023

Reviews in Medical Virology

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The immunopathology of herpes simplex virus (HSV)‐associated neuroinflammation is a captivating and intricate field of study within the scientific community. HSV, renowned for its latent infection capability, gives rise to a spectrum of neurological expressions, ranging from mild symptoms to severe encephalitis. The enigmatic interplay between the virus and the host's immune responses profoundly shapes the outcome of these infections. This review delves into the multifaceted immune reactions triggered by HSV within neural tissues, intricately encompassing the interplay between innate and adaptive immunity. Furthermore, this analysis delves into the delicate equilibrium between immune defence and the potential for immunopathology‐induced neural damage. It meticulously dissects the roles of diverse immune cells, cytokines, and chemokines, unravelling the intricacies of neuroinflammation modulation and its subsequent effects. By exploring HSV's immune manipulation and exploitation mechanisms, this review endeavours to unveil the enigmas surrounding the immunopathology of HSV‐associated neuroinflammation. This comprehensive understanding enhances our grasp of viral pathogenesis and holds promise for pioneering therapeutic strategies designed to mitigate the neurological ramifications of HSV infections.

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Stress as Trigger Factor of HSV-1 Reactivation Causing Recurrent Intraoral Herpes Mimicking HAEM: A Case Report

Hasanah¹,

Hidayat²

2022

IMCRJ

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This case highlights the role of stress as trigger factor of HSV-1 reactivation causing recurrent intraoral herpes mimicking herpes-associated erythema multiforme (HAEM). A 24-year-old female came with chief complaints of pain in the oral cavity followed by painful swallowing and fever. She admitted under stress due to family problems and also had insomnia for the last three years. Extra-oral examination revealed serosanguineous crusts on lips that were painful and easily bleed. Intra-oral examination showed the white-yellowish multiple and coalescent ulcers, irregular, and painful on the left and right buccal mucosa, upper and lower labial mucosa, dorsum of the tongue, the floor of the mouth, and oropharynx. The results of the Depression Anxiety and Stress Scale (DASS)-21 examination were moderate depression, extremely severe anxiety, and moderate stress. The results of the HSV-1 IgG examination before and after therapy were positive with titer > 200 U/mL. Pharmacological therapy included acyclovir 200 mg tablets, multivitamin, benzydamine HCl lozenges, 0.025% hyaluronic acid mouthwash, 0.9% NaCl, and 100% petroleum jelly. Non-pharmacological therapy included stress management such as self-encouragement and referral to consult with a professional. This therapy generated significant result. In conclusion, stress affects many systems in the body, including the oral cavity. Stress is one of the trigger factors for HSV-1 reactivation which can cause oral manifestation. Early detection of trigger factors is important for better treatment result.

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An Updated Overview of Herpes Simplex Virus-1 Infection: Insights from Origin to Mitigation Measures

Cited by 4 publications

References 139 publications

Seroprevalence of HSV1 among Taiz University lecturers, Officers and students

Seroprevalence of HSV1 among Taiz University lecturers, Officers and students

Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries

Stress as Trigger Factor of HSV-1 Reactivation Causing Recurrent Intraoral Herpes Mimicking HAEM: A Case Report

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