An updated meta-analysis of adjuvant chemotherapy after curative resection for gastric cancer

Neoadjuvant or adjuvant therapy for resectable gastric cancer: a systematic review and practice guideline for North America

“…No additional relevant studies were identified in a search of the Cochrane Library. Overall, 22 RCTs , 13 meta-analyses [34][35][36][37][38][39][40][41][42][43][44][45][46], and two secondary analyses that report survival data [47,48] are included in this systematic review (see Fig. 1).…”

“…Seven published literature meta-analyses were identified that compared postoperative chemotherapy versus surgery alone for patients with resected gastric cancer [34][35][36][37][38][39][40]. Study inclusion criteria, literature search periods, and statistical methods differed between the seven meta-analyses, although the basic research question was the same.…”

Multimodal Therapies for Upper Gastrointestinal Cancers – Past, Now, and Future

“…Therefore, the negative results of most previous clinical trials do not necessarily mean that the adjuvant CTx does not work. Several meta-analyses of adjuvant trials have been published (Earle & Maroun, 1999;GASTRIC Group, 2010;Hermans et al, 1993;Hu et al, 2002;Janunger et al, 2002;Liu et al, 2008;Mari et al, 2000;Oba et al, 2006;Panzini et al, 2002;Zhao & Fang, 2008) in order to overcome the drawbacks of small patient accrual and to assess any potential benefit by adjuvant therapy that may have been missed in the individual trials. Unfortunately, definitive evidence concerning benefits of adjuvant CTx is lacking, with results ranging from an odds ratio for death of 0.56-0.9 to no benefit.…”

Adjuvant chemotherapy for gastric cancer

“…• Использование АХТ статистически значимо уменьшает количество рецидивов [7]. На данный момент опубликовано большое количество РКИ, посвящённых изучению АХТ при РЖ.…”