An updated evaluation of the carcinogenic potential of 1,4-dioxane

Stickney, J. A.; Sager, Shawn L.; Clarkson, Jacquelyn; Smith, Lee; Locey, Betty J.; Bock, Michael; Hartung, R.; Olp, Steven F

doi:10.1016/s0273-2300(03)00090-4

Cited by 90 publications

(55 citation statements)

References 38 publications

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“…Many personal care products contain toxic substances with potential adverse health effects (Daughton and Ternes, 1999;CDC, 2005), such as phthalates, fragrance, nanoparticles, petroleum byproducts (1,4-dioxane), and triclosan. Some chemicals in personal care products are known to cause endocrine disruption, birth defects, or cancer (Szczurko et al, 1994;Stickney et al, 2003;Golden et al, 2005;Schettler, 2006).…”

Section: Introductionmentioning

confidence: 99%

Passive sampling methods to determine household and personal care product use

Bennett

Teague

et al. 2011

J Expo Sci Environ Epidemiol

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Traditionally, use of household and personal care products has been collected through questionnaires, which is very time consuming, a burden on participants, and prone to recall bias. As part of the SUPERB Project (Study of Use of Products and Exposure-Related Behaviors), a novel platform was developed using bar codes to quickly and reliably determine what household and personal care products people have in their homes and determine the amount used over a 1-week period. We evaluated the acceptability and feasibility of our methodology in a longitudinal field study that included 47 California households, 30 with young children and 17 with an older adult. Acceptability was defined by refusal rates; feasibility was evaluated in terms of readable bar codes, useful product information in our database for all readable barcodes, and ability to find containers at both the start and end of the week. We found 63% of personal care products and 87% of the household care products had readable barcodes with 47% and 41% having sufficient data for product identification, respectively and secondly, the amount used could be determined most of the time. We present distributions for amount used by product category and compare inter-and intra-person variability. In summary, our method appears to be appropriate, acceptable, and useful for gathering information related to potential exposures stemming from the use of personal and household care products. A very low drop-out rate suggests that this methodology can be useful in longitudinal studies of exposure to household and personal care products.

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Section: Introductionmentioning

confidence: 99%

Passive sampling methods to determine household and personal care product use

Bennett

Teague

et al. 2011

J Expo Sci Environ Epidemiol

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“…Six genotoxic carcinogens; diethylstilbestrol, urethane, chlorambucil, dibenz (a,h)anthracene, methyl methanesulfonate, and N-nitroso-Nmethylurea, were chosen (Gladek and Liehr, 1989;Hübner et al, 1997;Mlcoch et al, 1993;Palmer et al, 1984;Tinwell et al, 1998;Zarbl et al, 1985). In addition, six nongenotoxic carcinogens; O-nitrotoluene, 1,4-dioxane, tetrachloroethylene, 2,3,7,8-tetrachlorodibenzo-p-dioxine (TCDD), chloroprene, nitrobenzene, and nitromethane were selected (Biswas et al, 2008;Hetch, 2002;Hsu et al, 2007;Hurst, 2007;Paulu et al, 1999;Sills et al, 2004;Stickney et al, 2003). L5178Y mouse lymphoma cells were exposed to genotoxic and nongenotoxic carcinogens at the biologically effective concentrations (Tables 2 and 3) determined by cytotoxicity test (Go and Sheen, 2008).…”

Section: Resultsmentioning

confidence: 99%

Moesin Is a Biomarker for the Assessment of Genotoxic Carcinogens in Mouse Lymphoma

Lee

Choi

Sheen

et al. 2012

Molecules and Cells

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“…9) A six-compartment PBPK model for 1,4-dioxane in humans has been reported. 8) Although oral administration of chemicals is a key route of exposure based on toxicology testing, 10) chemical concentrations absorbed from other routes, such as inhalation, could be handled in a similar PBPK modeling system.…”

Section: Discussionmentioning

confidence: 99%

“…7,8) 1,4-Dioxane ( Fig. 1) is widely used, primarily as a solvent or as a solvent stabilizer, 9) but subchronic oral toxicity of 1,4-dioxane has been examined in rats by administering 1,4-dioxane in drinking water, suggesting hepatic and renal failures. 10) 1,4-Dioxane is believed to be primarily metabolized by P450s to 2-(2-hydroxyethoxy)acetic acid or its interconversion product 1,4-dioxiane-2-one ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling

Takano

Murayama

Horiuchi

et al. 2010

JOURNAL OF HEALTH SCIENCE

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The present study defined a simplified physiologically based pharmacokinetic (PBPK) model for 1,4-dioxane in humans based on in vitro metabolic parameters determined using relevant liver microsomes, coefficients derived in silico, physiological parameters derived from the literature, and a developed PBPK model in rats. The model consists of a chemical absorption compartment, a metabolizing compartment, and a central compartment for 1,4-dioxane. Evaluation of the rat model was performed by comparisons with experimental pharmacokinetic values from blood and urine obtained from rats in vivo after daily oral treatment with 1,4-dioxane (500 mg/kg, a noobserved-adverse-effect level) for 14 days. Elimination rates of 1,4-dioxane in vitro were established using data from rat liver microsomes and from pooled human liver microsomes. 1,4-Dioxane was expected to be absorbed and cleared rapidly from the body in silico, as was the case for rats confirmed experimentally in vivo with repeated low-dose treatments. These results indicate that the simplified PBPK model for 1,4-dioxane is useful for a forward dosimetry approach in humans. This model may also be useful for simulating blood concentrations of other related compounds resulting from exposure to low chemical doses.

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An updated evaluation of the carcinogenic potential of 1,4-dioxane

Cited by 90 publications

References 38 publications

Passive sampling methods to determine household and personal care product use

Passive sampling methods to determine household and personal care product use

Moesin Is a Biomarker for the Assessment of Genotoxic Carcinogens in Mouse Lymphoma

Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling

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