An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective study

Philipsen, H. P.; Reichart, Peter A.; Siar, Chong Huat; Ng, Kok Han; Lau, Shin Hin; Zhang, Xiaolin; Dhanuthai, Kittipong; Swasdison, Somporn; Jainkittivong, Aree; Meer, Shabnum; Jivan, Vibha; Altini, Mario; Hazarey, Vinay K.; Ogawa, Ikuko; Takata, Takashi; Taylor, Adalberto Abel Mosqueda; Godoy, Héctor; Delgado, W.; Carlos-Bregni, Román; Macias, Juan Fransisco Reyes; Matsuzaka, Kenichi; Sato, Daisuke; Vargas, Pablo Agustı́n; Adebayo, Ezekiel Taiwo

doi:10.1111/j.1600-0714.2007.00536.x

Cited by 140 publications

(176 citation statements)

References 91 publications

(68 reference statements)

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“…It has been generally reported that AOT corresponds to 2.2-8.7 % of all odontogenic tumors [2,10,19]. However, in a worldwide collaborative retrospective study, the relative frequency of AOT ranged from 0.6 to 38.5 % [4]. Interestingly, the highest percentages were found in studies from Nigeria, which might suggest geographic differences in the frequency of these tumors [4].…”

Section: Discussionmentioning

confidence: 92%

“…However, in a worldwide collaborative retrospective study, the relative frequency of AOT ranged from 0.6 to 38.5 % [4]. Interestingly, the highest percentages were found in studies from Nigeria, which might suggest geographic differences in the frequency of these tumors [4]. Nonetheless, it must be emphasized that the recent inclusion of odontogenic keratocysts in the group of odontogenic tumors [20] may make in some instances a marked impact on the reported relative frequency of AOT [4].…”

Section: Discussionmentioning

confidence: 98%

“…The AOT is a benign odontogenic lesion that has been regarded either as a non-aggressive, non-invasive neoplasm or as a developmental hamartomatous growth [4,18]. It has been generally reported that AOT corresponds to 2.2-8.7 % of all odontogenic tumors [2,10,19].…”

Section: Discussionmentioning

confidence: 99%

“…Credit has been giving to Harbiz [3] for reporting the earliest case demonstrating irrefutable proof of an AOT, in 1915. On the other hand, Stafne, in 1948, was the first author who considered AOT as an entity although he did not propose a specific name for it [4]. In 1969, Philipsen and Birn [5] introduced the term 'adenomatoid odontogenic tumor', to be adopted by the World Health Organization (WHO) classification of odontogenic tumors in 1971 [6], and it is now the generally accepted nomenclature.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the relatively large number of studies about demographic, clinical and radiologic features of AOT [4,7,9,11,12], information regarding the frequency of the many histopathologic aspects of this lesion is scarce [8,13,14]. Thus, the aim of this study was to perform a retrospective analysis in a case series of AOT, with emphasis on the histopathological features, in order to provide useful additional data to the literature.…”

Section: Introductionmentioning

confidence: 99%

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Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

Matos

Nonaka

Pinto

et al. 2012

Head and Neck Pathol

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Adenomatoid odontogenic tumor (AOT) is an uncommon benign epithelial lesion of odontogenic origin and, thus far, only few studies regarding the frequency of its many histopathologic features have been published in the literature. Thus, the aim of this study was to perform a retrospective analysis in a case series of AOT, with emphasis on the histopathological features. Fifteen cases of AOT were studied considering their clinical, radiographic and histopathologic aspects. Twelve cases affected females and the mean age was 16.2 years. The anterior maxilla was the most common site (66.6 %) and radiographically most cases showed a unilocular radiolucency with well-defined borders (57.1 %). Histologically, most cases exhibited predominantly a solid growth pattern (46.7 %) or a similar proportion of solid and cribriform patterns (46.7 %). Eosinophilic amorphous material (''tumor droplets'') was found in all cases (100 %). Most tumors showed duct-like spaces (93.3 %) and convoluted structures (60.0 %) whereas a minor proportion of cases presented calcifying epithelial odontogenic tumor (CEOT)-like areas (26.7 %). Variable amounts of calcified material were found in most AOTs (80.0 %) whereas osteodentin and perivascular hyalinization were seen only rarely (6.7 % each one). Five (33.3 %) cases had areas mimicking a dentigerous cyst and most of these were diagnosed in females (80.0 %). Regarding the histopathologic features, our results suggest that AOTs usually show predominance of solid pattern or a similar proportion of solid and cribriform patterns while osteodentin and perivascular hyalinization are rarely seen in these tumors. In addition, areas mimicking a dentigerous cyst and CEOT-like areas are relatively infrequent findings in AOTs.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

Matos

Nonaka

Pinto

et al. 2012

Head and Neck Pathol

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Radiopacities

MacDonald¹

2011

Oral and Maxillofacial Radiology

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Dental implants at sites of focal high and mixed density osseous lesions: Treatment strategies

Akers

Wagner²,

Vargas³

et al. 2022

Clin Adv Periodontics

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Focused Clinical Question Under what circumstances may a clinician consider dental implant placement at a site exhibiting a focal high or mixed density (HMD) osseous lesion radiologically? Summary Some conditions and pathologic entities exhibiting high and mixed density radiological appearance pose low risk for dental implant failure or complications following implant surgery. However, other lesions represent contraindications to implant placement, and implant surgery at such sites can result in severe morbidity. Conclusion Potential implant sites exhibiting focal HMD osseous lesions/conditions present varying levels of risk. In most cases, optimal management will include advanced imaging of the site, multidisciplinary consultations, and detailed informed consent to assure full understanding of procedural risks, benefits, and complications. Currently, clinical recommendations rely on case reports, opinion, and usual practice (level 3 evidence). The strength of each recommendation provided in this report is categorized as level C.

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An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective study

Abstract: This updated review based on the largest number of AOT cases ever presented, confirms the distinctive, although not pathognomonic clinicopathological profile of the AOT, its worldwide occurrence, and its consistently benign behaviour.

Cited by 140 publications

References 91 publications

Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

Radiopacities

Dental implants at sites of focal high and mixed density osseous lesions: Treatment strategies

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