An Update on Transcatheter Aortic Valve Replacement

Gössl, Mario; Holmes, David R.

doi:10.1016/j.cpcardiol.2013.04.002

Cited by 4 publications

(3 citation statements)

References 97 publications

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“…42 Nearly half of the patients in the cohort underwent 2nd-generation TAVI for treatment of NAVR. Notably, outcomes with 2nd-generation valves were significantly improved over those with 1st-generation systems.…”

Section: Following the Prisma Guidelines Checklist (Supplementarymentioning

confidence: 99%

Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation　― A Systematic Review ―

Yousef

MacDonald

Simard

et al. 2018

Circ J

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Background: Transcatheter aortic valve implantation (TAVI) has become the standard of care for management of high-risk patients with aortic stenosis. Limited data is available regarding the performance of TAVI in patients with native aortic valve regurgitation (NAVR). Methods and Results:We performed a systematic review from 2002 to 2016. The primary outcome was device success as per VARC-2 criteria. Secondary endpoints included procedural complications, and 30-day and 1-year mortality rates. A total of 175 patients were included from 31 studies. Device success was reported in 86.3% of patients -with device failure driven by moderate aortic regurgitation (AR ≥3+) and/or need for a second device. Procedural complications were rare, with no procedural deaths, myocardial infarctions or annular ruptures reported. Procedural safety was acceptable with a low 30-day incidence of stroke (1.5%). The 30-day and 1-year overall mortality rates were 9.6% and 20.0% (cardiovascular death, 3.8% and 10.1%, respectively). Patients receiving 2nd-generation valves demonstrated similar safety profiles with greater device success compared with 1st-generation valves (96.2% vs. 78.4%). This was driven by the higher incidence of second-valve implantation (23.4% vs. 1.7%) and significant paravalvular leak (8.3% vs. 0.0%).Conclusions: TAVI demonstrates acceptable safety and efficacy in high-risk patients with severe NAVR. Second-generation valves may afford a similar safety profile with improved device success. Dedicated studies are needed to definitively establish the efficacy of TAVI in this population.

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Section: Following the Prisma Guidelines Checklist (Supplementarymentioning

confidence: 99%

Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation　― A Systematic Review ―

Yousef

MacDonald

Simard

et al. 2018

Circ J

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“…Stent placement is employed as a minimally invasive treatment for pathologies within the cardiovascular system (1). Stents are used to open narrowed blood vessels and form a scaffold (2–4), treat enlargement and weakening of the artery due to aneurysms (5), and support valves in minimally invasive techniques of heart valve replacement (6, 7). This range of applications requires devices with deployed diameters from around 3 mm in coronary applications to over 40 mm for interventions associated with the pulmonary and aortic valves.…”

Section: Introductionmentioning

confidence: 99%

Measurement of in vitro and in vivo Stent Geometry and Deformation by Means of 3D Imaging and Stereo-Photogrammetry

et al. 2014

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“…Since the first human intervention in 2002, there have been over 50,000 TAVR procedures. 4,5 However, these valves can introduce the patient to other complications, such as major vascular bleeding and stroke. A correct understanding of the anatomy of the aortic root is, therefore, vital when considering the design of a prosthetic valve, particularly in the case of a transcatheter-delivered valve which sandwiches the native leaflets between the stent and the aortic wall and may create an obstruction to flow.…”

Section: Introductionmentioning

confidence: 99%

The aortic valve: structure, complications and implications for transcatheter aortic valve replacement

2014

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The aortic valve operates in a complex haemodynamic environment, opening and closing over 100,000 times a day. When complications arise, such as aortic stenosis, prognosis can be very poor, leading to death within the first few years. Surgical valve replacement is currently the standard treatment for aortic stenosis. A thorough understanding of the anatomy and function of the native valve is imperative when developing a prosthetic replacement that can withstand the complex demands of the heart. This review focuses on the anatomy, structure and disease of the aortic valve and the implications for a transcatheter aortic valve replacement (TAVR). Current complications with TAVR, such as major vascular bleeding, conduction disturbances and patient-prosthesis mismatch (PPM), can be overcome by reducing the delivery profile and through the use of more accurate imaging technologies to work towards a fully functional and durable prosthesis.

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An Update on Transcatheter Aortic Valve Replacement

Cited by 4 publications

References 97 publications

Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation　― A Systematic Review ―

Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation　― A Systematic Review ―

Measurement of in vitro and in vivo Stent Geometry and Deformation by Means of 3D Imaging and Stereo-Photogrammetry

The aortic valve: structure, complications and implications for transcatheter aortic valve replacement

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An Update on Transcatheter Aortic Valve Replacement

Cited by 4 publications

References 97 publications

Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation ― A Systematic Review ―

Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation ― A Systematic Review ―

Measurement of in vitro and in vivo Stent Geometry and Deformation by Means of 3D Imaging and Stereo-Photogrammetry

The aortic valve: structure, complications and implications for transcatheter aortic valve replacement

Contact Info

Product

Resources

About

Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation　― A Systematic Review ―

Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation　― A Systematic Review ―