An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review

Sun, Hong; Sun, Rong; Hua, Yulin; Lu, Qianyi; Shao, Xinyu

doi:10.3389/fmed.2023.1153805

Cited by 3 publications

(1 citation statement)

References 51 publications

(59 reference statements)

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“…DN is a common and serious complication of diabetes mellitus (DM) and is considered a serious chronic kidney disease (CKD), which is a leading cause of end-stage renal disease (ESRD). Currently, the incidence of DN has increased worldwide [12]. Therefore, in recent years, an increasing number of molecular mechanisms underlying the pathogenic significance of inflammation in DN have been elucidated [13].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Anti-Cholera and Active Diabetic Renoprotective Compounds of Maqian Essential Oil: A Computational and Molecular Dynamics Study

Dahab,

Zhang,

Al-Mijalli

et al. 2023

Molecules

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Cholera is an exceptionally aggressive infectious disease characterized by the potential to induce acute, copious, watery diarrhea of considerable severity and renal inflammation. Diabetic nephropathy is a serious complication of diabetes mellitus that can lead to kidney failure through inflammation; thus, anti-inflammatory agents are promising therapies for diabetic nephropathy. Previous studies have shown that the essential oil of Zanthoxylum myriacanthum var. pubescens Huang, Maqian essential oil (MQEO), exhibits potent antibacterial, anti-inflammatory, and renoprotective activities in diabetic mice and has emerged as a potential therapeutic drug for the treatment of diabetic nephropathy complications. Therefore, the present study was carried out to screen the potential inhibition of cholera toxin and the diabetic renoprotective activity of MQEO through computational approaches. Twelve chemical constituents derived from MQEO were docked with cholera toxin and the target proteins involved in diabetic nephropathy, namely, TXNIP, Nrf2, and DPP IV, and, subsequently, the predictions of molecular dynamic simulations, the drug-likeness properties, and the ADMET properties were performed. α-terpineol showed high binding affinities toward the cholera toxin protein. For TXNIP, among all the chemical constituents, α-phellandrene and p-cymene showed strong binding affinities with the TXNIP protein and displayed relatively stable flexibility at the hinge regions of the protein, favorable physicochemical properties in the absence of hepatotoxicity, and low cytotoxicity. For Nrf2, α-terpineol exhibited the highest binding affinity and formed a very stable complex with Nrf2, which displayed high pharmacokinetic properties. All compounds had low free-binding energies when docked with the DPP IV protein, which suggests potent biological activity. In conclusion, based on a computational approach, our findings reveal that MQEO constituents have inhibitory activity against cholera toxin and are promising therapeutic agents for suppressing diabetic inflammation and for the treatment of diabetic nephropathy complications.

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Section: Introductionmentioning

confidence: 99%

Unveiling the Anti-Cholera and Active Diabetic Renoprotective Compounds of Maqian Essential Oil: A Computational and Molecular Dynamics Study

Dahab,

Zhang,

Al-Mijalli

et al. 2023

Molecules

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Targeting DNA methylation in diabetic kidney disease: A new perspective

Akhouri,

Majumder,

Gaikwad

2023

Life Sciences

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Update: the role of epigenetics in the metabolic memory of diabetic complications

Chen,

Malek,

Natarajan

2024

American Journal of Physiology-Renal Physiology

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Diabetes, a chronic disease characterized by hyperglycemia, is associated with significantly accelerated complications, including diabetic kidney disease (DKD), which increase morbidity and mortality. Hyperglycemia and other diabetes-related environmental factors such as overnutrition, sedentary lifestyles and hyperlipidemia can induce epigenetic changes. Working alone or with genetic factors, these epigenetic changes, that occur without alterations in the underlying DNA sequence, can alter the expression of pathophysiological genes and impair functions of associated target cells/organs, leading to diabetic complications like DKD. Notably, some hyperglycemia-induced epigenetic changes persist in target cells/tissues even after glucose normalization, leading to sustained complications despite glycemic control, so called metabolic memory. Emerging evidence from in-vitro, in-vivo animal models and clinical trials with diabetes subjects identified clear associations between metabolic memory and epigenetic changes including DNA methylation, histone modifications, chromatin structure, and noncoding RNAs at key loci. Targeting such persistent epigenetic changes and/or molecules regulated by them can serve as valuable opportunities to attenuate, or erase metabolic memory, which is crucial to prevent complication progression. Here, we review these cell/tissue-specific epigenetic changes identified to-date as related to diabetic complications, especially DKD, and the current status on targeting epigenetics to tackle metabolic memory. We also discuss limitations in current studies, including the need for more (epi)genome-wide studies, integrative analysis using multiple epigenetic marks and Omics datasets, and mechanistic evaluation of metabolic memory. Considering the tremendous technological advances in epigenomics, genetics, sequencing, and availability of genomic datasets from clinical cohorts, this field is likely to see considerable progress in the upcoming years.

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An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review

Cited by 3 publications

References 51 publications

Unveiling the Anti-Cholera and Active Diabetic Renoprotective Compounds of Maqian Essential Oil: A Computational and Molecular Dynamics Study

Unveiling the Anti-Cholera and Active Diabetic Renoprotective Compounds of Maqian Essential Oil: A Computational and Molecular Dynamics Study

Targeting DNA methylation in diabetic kidney disease: A new perspective

Update: the role of epigenetics in the metabolic memory of diabetic complications

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