An update on the role of miRNA-155 in pathogenic microbial infections

Zeng, Furong; Tang, Lijun; He, Ye; García, Rafael Martínez

doi:10.1016/j.micinf.2015.05.007

Cited by 37 publications

(26 citation statements)

References 83 publications

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“…Among them, miR-155, miR-146a, and miR-21 are associated with inflammation and immune modulation Zeng et al, 2015;Zhang et al, 2015a). MiR-155 suppresses Toll-like receptors (TLRs) and triggers an immune response (Sun et al, 2012).…”

Section: Ebv Latent Proteins Dysregulate Host Mirnas To Regulate the mentioning

confidence: 99%

An update: Epstein-Barr virus and immune evasion via microRNA regulation

Zuo

Yue

et al. 2017

Virol. Sin.

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Epstein-Barr virus (EBV) is an oncogenic virus that ubiquitously establishes life-long persistence in humans.To ensure its survival and maintain its B cell transformation function, EBV has developed powerful strategies to evade host immune responses. Emerging evidence has shown that microRNAs (miRNAs) are powerful regulators of the maintenance of cellular homeostasis. In this review, we summarize current progress on how EBV utilizes miRNAs for immune evasion. EBV encodes miRNAs targeting both viral and host genes involved in the immune response. The miRNAs are found in two gene clusters, and recent studies have demonstrated that lack of these clusters increases the CD4 + and CD8 + T cell response of infected cells. These reports strongly indicate that EBV miRNAs are critical for immune evasion. In addition, EBV is able to dysregulate the expression of a variety of host miRNAs, which influence multiple immune-related molecules and signaling pathways. The transport via exosomes of EBV-regulated miRNAs and viral proteins contributes to the construction and modification of the inflammatory tumor microenvironment. During EBV immune evasion, viral proteins, immune cells, chemokines, pro-inflammatory cytokines, and pro-apoptosis molecules are involved. Our increasing knowledge of the role of miRNAs in immune evasion will improve the understanding of EBV persistence and help to develop new treatments for EBV-associated cancers and other diseases.

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Section: Ebv Latent Proteins Dysregulate Host Mirnas To Regulate the mentioning

confidence: 99%

An update: Epstein-Barr virus and immune evasion via microRNA regulation

Zuo

Yue

et al. 2017

Virol. Sin.

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“…This miRNA is abundantly expressed in immune cells such as macrophages and active B and T cells and in dendritic cells. It is involved in the immune response, as well as in protection against the harmful effects of inflammation through the modulation of pathways related to apoptosis, proliferation, and host-pathogen interactions (29). Interestingly, in human gingival tissues affected by PD, an increase in miR-155 expression has already been observed (18), with several pathogens seemingly able to increase it.…”

Section: Gingivalis (Pg) (A To C) Combination (P Gingivalis and Mirmentioning

confidence: 99%

Identification and Characterization of MicroRNA Differentially Expressed in Macrophages Exposed to Porphyromonas gingivalis Infection

et al. 2017

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MicroRNAs (miRNAs) are short, noncoding RNAs involved in the regulation of several processes associated with inflammatory diseases and infection. Bacterial infection modulates miRNA expression to subvert any innate immune response. In this study we analyzed, using microarray analysis, the bacterial modulation of miRNAs in bone marrow-derived macrophages (BMMs) in which activity was induced by infection with Porphyromonas gingivalis. The expression of several miRNAs was modulated 3 h postinfection (at a multiplicity of infection of 25). A bioinformatic analysis was performed to further identify pathways related to the innate immune host response under the influence of selected miRNAs. To assess the effects of the miRNAs identified on cytokine secretion (tumor necrosis factor alpha [TNF-␣] and interleukin-10 [IL-10]), BMMs were transfected with selected miRNA mimics and inhibitors. Transfection with mmu-miR-155 and mmumiR-2137 did not modify TNF-␣ secretion, while their inhibitors increased it. Inhibitors of mmu-miR-2137 and mmu-miR-7674 increased the secretion of the anti-inflammatory factor IL-10. In P. gingivalis-infected BMMs, mmu-miR-155-5p significantly decreased TNF-␣ secretion while inhibitor of mmu-miR-2137 increased IL-10 secretion. In vivo, in a mouse model of P. gingivalis-induced calvarial bone resorption, injection of mmu-miR-155-5p or anti-mmu-miR-2137 reduced the size of the lesion significantly. Furthermore, anti-mmu-miR-2137 significantly reduced inflammatory cell infiltration, osteoclast activity, and bone loss. Bioinformatic analysis demonstrated that pathways related to cytokine-and chemokinerelated pathways but also osteoclast differentiation may be involved in the effects observed. This study contributes further to our understanding of P. gingivalis-induced modulation of miRNAs and their physiological effects. It highlights the potential therapeutic merits of targeting mmu-miR-155-5p and mmumiR-2137 to control inflammation induced by P. gingivalis infection.

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“…Infection by different pathogens leads to the expression of specific microRNA sets that are regulated in a time-dependent manner [24]. Among them, miR-155, miR-146, let-7 and miR-29 play important roles in the host cells response to bacteria [25][26][27][28]. These miRNAs regulate the immune responses in order to clear bacterial infection, while preserving the organism from deleterious effects of inflammation.…”

Section: Discovery Of Microrna Response Against Pathogensmentioning

confidence: 99%

Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk

Duval

Cossart

Lebreton

2017

Seminars in Cell & Developmental Biology

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Gene expression regulation is a critical question in host-pathogen interactions, and RNAs act as key players in this process. In this review, we focus on the mammalian RNA response to bacterial infection, with a special interest on microRNAs and long non-coding RNAs. We discuss the role of cellular miRNAs in immunity, the implication of circulating miRNAs as well as the influence of the microbiome on the miRNA response. We also review how pathogens counteract the host miRNA expression. Interestingly, bacterial non-coding RNAs regulate host gene expression and conversely eukaryotic miRNAs may regulate bacterial gene expression. Overall, the characterization of RNA regulatory networks represents an emerging theme in the field of host pathogen interactions.

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An update on the role of miRNA-155 in pathogenic microbial infections

Cited by 37 publications

References 83 publications

An update: Epstein-Barr virus and immune evasion via microRNA regulation

An update: Epstein-Barr virus and immune evasion via microRNA regulation

Identification and Characterization of MicroRNA Differentially Expressed in Macrophages Exposed to Porphyromonas gingivalis Infection

Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk

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