An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort

Lim, Jun Jie; Lim, Ying Yi Eliza; Ng, Jun Yan; Malipeddi, Praneeth; Ng, Yu Ting; Teo, Wei Yi; Wong, Qi Yi Ambrose; Matta, Sri Anusha; Sio, Yang Yie; Wong, Yi Ru; Teh, Keng Foo; Shah, Smyrna Moti Rawanan; Reginald, Kavita; Say, Yee‐How; Chew, Fook Tim

doi:10.1016/j.waojou.2022.100722

Cited by 23 publications

(33 citation statements)

References 58 publications

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“…This is in accordance with the validated guidelines of the UK Working Party’s diagnostic criteria and Hanifin and Rajka criteria [[27], [28]]. The incorporation of SPT in defining various atopic diseases showed high sensitivity and specificity in our previous studies [[3], [23], [29], [30]].…”

Section: Methodssupporting

confidence: 84%

“…This is in accordance with the validated guidelines of the UK Working Party's diagnostic criteria and Hanifin and Rajka criteria [27,28]. The incorporation of SPT in defining various atopic diseases showed high sensitivity and specificity in our previous studies [3,23,29,30]. All 11,494 Chinese subjects were grouped mainly into either an atopic case (SPT positive with disease symptoms), non-atopic nondisease control (SPT negative without disease symptoms), or atopic non-disease control (SPT positive but without disease symptoms).…”

Section: Defining Diseasessupporting

confidence: 87%

“…These 11,494 Chinese subjects also formed the population for our Singapore/Malaysia Crosssection Genetics Study (SMCGES). Refer to Lim et al [23] for more details on the SMCGES demographic characteristics and recruitment process.…”

Section: Subjects and Data Collectionmentioning

confidence: 99%

“…Interestingly, atopic diseases are direct outcomes of long-term unresolved inflammatory responses and a diet high in dietary fat composition can result in low-grade chronic tissue inflammation [[15], [16]]. In our recent epidemiology study, the frequent consumption of burgers/fast food, butter, and margarine was shown to increase the associated risks for moderate-to-severe AD [[17]].…”

Section: Introductionmentioning

confidence: 99%

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A Dietary Pattern for High Estimated Total Fat Amount Is Associated with Enhanced Allergy Sensitization and Atopic Diseases among Singapore/Malaysia Young Chinese Adults

Lim

Reginald

Say

et al. 2023

Int Arch Allergy Immunol

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Introduction: Frequent dietary patterns for fast food diets are suggested to be a risk factor for atopic disease development. Excessive dietary fats in fast foods are postulated to promote low-grade chronic inflammation. However, no studies in Asia have yet to characterize the dietary pattern for high-fat foods with atopic diseases. Thus, this study aims to assess the association between dietary fats with the prevalence of atopic diseases in an allergic cohort. Methods: Through an investigator-administered questionnaire that follows the International Study of Asthma and Allergies in Childhood (ISAAC) protocol, we evaluated the eating habits, lifestyle behaviours, sociodemographics, and atopic symptoms, and history among 11,494 young Chinese adults in Singapore and Malaysia. A skin prick test (SPT) for common house dust mites was also conducted to determine the atopic (allergic) status. We identified 1,550 atopic dermatitis (AD), 1,301 allergic asthma (AS), and 3,757 allergic rhinitis (AR) atopic cases. We derived a novel dietary index, Diet Quality based on Total Fat Amount (DQTFA), to examine the association between eating patterns for estimated total fat amount with various atopic outcomes. Results: There was a preponderance of subjects having positive SPT reaction (69.0%) with the prevalence of AR being the highest (32.7%), then AD (13.5%), and AS (11.3%). Additionally, there is a significantly higher proportion of subjects with an atopy background and atopic diseases consume diets with a high estimated mean fat amount. The adherence to a dietary pattern of the higher estimated total fat amount was shown to be strongly associated with all atopic diseases and exhibited dose-dependent responses in the univariate analysis. These associations remained significant even with the adjustments for age, gender, body mass index, use of alcohol, sedentary lifestyles, and physical activity. A dietary pattern for high-fat amount is more strongly associated with AS (adjusted odds ratio [AOR]: 1.524; 95% confidence interval [CI]: 1.216–1.725; p < 0.001) and AR (AOR: 1.294; 95% CI: 1.107–1.512; p < 0.001) compared to AD (AOR: 1.278; 95% CI: 1.049–1.559; p < 0.05). Finally, it was shown that having either one of the atopic comorbidities was strongly associated with a dietary pattern of high-fat amounts (AOR: 1.360; 95% CI: 1.161–1.594; p < 0.001). Conclusion: Our findings altogether provide initial evidence that the dietary pattern of a diet high in fat amount is associated with an increased risk of atopy and atopic diseases in young Chinese adults in Singapore and Malaysia. Balancing the consumption of dietary fats and changing personal dietary habits by choosing foods of the lower fat amount may reduce the associated odds of atopic diseases.

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Section: Methodssupporting

confidence: 84%

Section: Defining Diseasessupporting

confidence: 87%

Section: Subjects and Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Dietary Pattern for High Estimated Total Fat Amount Is Associated with Enhanced Allergy Sensitization and Atopic Diseases among Singapore/Malaysia Young Chinese Adults

Lim

Reginald

Say

et al. 2023

Int Arch Allergy Immunol

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“…This present study belongs to a part of an ongoing Singapore and Malaysia cross-sectional genetic and epidemiological study (SMCSGES). The recruitment of this cohort has been previously described [20][21][22][23]. Participants were recruited from the National University of Singapore (NUS) from Aug 2005 to Sep 2009, whereas pediatric asthmatic patients were recruited from KK Hospital in Singapore from January 2004 to December 2007.…”

Section: Study Design and Participant Recruitmentmentioning

confidence: 99%

Functional Polymorphisms of the Arachidonic Acid Pathway Associate with Risks and Clinical Outcomes of Allergic Diseases

Sio,

Shi,

Matta

et al. 2023

Int Arch Allergy Immunol

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Introduction: The arachidonic acid (AA) pathway plays a crucial role in allergic inflammatory diseases; however, the functional roles of allergy-associated single nucleotide polymorphisms (SNPs) in this pathway remain incompletely illustrated. Methods: This study belongs to a part of an ongoing Singapore/Malaysia cross-sectional genetics and epidemiological study (SMCSGES). We performed population genotyping on n = 2,880 individuals from the SMCSGES cohort to assess the associations of SNPs in the AA pathway genes with asthma and allergic rhinitis (AR). Spirometry assessments were performed to identify associations between SNPs and lung function among n = 74 pediatric asthmatic patients from the same cohort. Allergy-associated SNPs were functionally characterized using in vitro promoter luciferase assay, along with DNA methylome and transcriptome data of n = 237 peripheral blood mononuclear cell (PBMC) samples collected from a subset of the SMCSGES cohort. Results: Genetic association analysis showed 5 tag-SNPs from 4 AA pathway genes were significantly associated with asthma (rs689466 at COX2, rs35744894 at hematopoietic PGD2 synthase (HPGDS), rs11097414 at HPGDS, rs7167 at CRTH2, and rs5758 at TBXA2R, p < 0.05), whereas 3 tag-SNPs from HPGDS (rs35744894, rs11097414, and rs11097411) and 2 tag-SNPs from PTGDR (rs8019916 and rs41312470) were significantly associated with AR (p < 0.05). The asthma-associated rs689466 regulates COX2 promoter activity and associates with COX2 mRNA expression in PBMC. The allergy-associated rs1344612 was significantly associated with poorer lung function, increased risks of asthma and AR, and increased HPGDS promoter activity. The allergy-associated rs8019916 regulates PTGDR promoter activity and DNA methylation levels of cg23022053 and cg18369034 in PBMC. The asthma-associated rs7167 affects CRTH2 expression by regulating the methylation level of cg19192256 in PBMC. Conclusions: The present study identified multiple allergy-associated SNPs that modulate the transcript expressions of key genes in the AA pathway. The development of a “personalized medicine” approach with consideration of genetic influences on the AA pathway may hopefully result in efficacious strategies to manage and treat allergic diseases.

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Association of frequent intake of trans fatty acids and saturated fatty acids in diets with increased susceptibility of atopic dermatitis exacerbation in young Chinese adults: A cross‐sectional study in Singapore/Malaysia

Lim,

Reginald

et al. 2024

Skin Health and Disease

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Background & ObjectiveNumerous evidence has attributed diets with a high fatty acids (FAs) intake to be associated with atopic dermatitis (AD) development. Therefore, this study investigated the association between intake frequencies of five dietary FAs and AD exacerbations among young Chinese adults from Singapore and Malaysia.MethodsA validated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was investigator‐administered to 13,561 subjects to collect information on socioeconomic, anthropometric, dietary and lifestyles habits, and personal/family medical histories. Six novel dietary indices were derived to analyse the associations between total FAs, trans fatty acids (TFAs), saturated fatty acids (SFAs), monounsaturated fatty acids, linoleic acids, and alpha‐linolenic acids in diets and AD exacerbation. Synergy factor (SF) analysis was used to identify interactions between the dietary FAs to influence disease susceptibility.ResultsIn our multivariable model adjusted for age, gender, BMI, parental eczema, and lifestyle factors, a diet high in total estimated FAs was strongly associated with AD (Adjusted Odds Ratio (AOR): 1.227; 95% Confidence Interval (CI): 1.054–1.429; adjusted p‐value <0.01). Particularly, high estimated total TFAs and SFAs were significantly associated with AD exacerbations including chronic and current moderate‐to‐severe AD. The association between TFAs and AD remained strong even controlled for the total FAs in diets and false discovery rate corrected (AOR: 1.516; 95% CI: 1.094–2.097; adjusted p‐value <0.05). Similarly, having a high SFAs in diets was associated with AD (AOR: 1.581; 95% CI: 1.106–2.256; adjusted p‐value <0.05) independently on the total FAs in diets. FAs in diets do not interact to influence AD.ConclusionOverall, these results highlighted an association between high dietary TFAs and SFAs and AD exacerbations in an Asian population.

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An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort

Cited by 23 publications

References 58 publications

A Dietary Pattern for High Estimated Total Fat Amount Is Associated with Enhanced Allergy Sensitization and Atopic Diseases among Singapore/Malaysia Young Chinese Adults

A Dietary Pattern for High Estimated Total Fat Amount Is Associated with Enhanced Allergy Sensitization and Atopic Diseases among Singapore/Malaysia Young Chinese Adults

Functional Polymorphisms of the Arachidonic Acid Pathway Associate with Risks and Clinical Outcomes of Allergic Diseases

Association of frequent intake of trans fatty acids and saturated fatty acids in diets with increased susceptibility of atopic dermatitis exacerbation in young Chinese adults: A cross‐sectional study in Singapore/Malaysia

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